↓基礎研究　↓臨床研究　↓業績：英語論文（2010～）

● 基礎研究

Evaluation of Conditions for the Development of Cryogenic Spinal Cord Injury Using a Canine Model: An Experimental Study on the Safety of Cryoablation for Metastatic Spinal Tumors

転移性脊椎腫瘍に対する凍結療法の安全性の検討 －脊髄低温障害の発生条件についての実験的研究－

Kobayashi M, et al. Am J Neuroradiol. 45:424-431, 2024

凍結療法（cryoablation）は放射線治療に抵抗性のがん種にも効果が報告されているだけでなく、凍結により抗原変性をおこさず腫瘍細胞を死滅させることで“がん免疫”を賦活することも報告されており、近年注目されている治療である。当研究室ではこのcryoablationを応用した転移性脊椎腫瘍に対する新たな治療法の開発に取り組んでいる。しかしながら脊椎に対するcryoablationでは凍結による脊髄低温障害が起きうるため、その安全性が危惧される。本研究の目的は脊髄低温障害の発生条件を解明することで、その予防法の確立に資することである。

検討にはイヌ14匹を用いた。全身麻酔下に第13胸椎椎体にプローブを挿入し液体窒素で冷却することで10分間のcryoablationを施行した（図1）。冷却開始から冷却後2時間まで第13 胸椎硬膜外温度の計測と脊髄モニタリングを施行した。処置翌日に後肢運動機能を評価し処置7日後に脊髄を含め第13胸椎を摘出し病理標本を作製した。10分のcryoablationにおける各個体の最低硬膜外温度は低い順に-37,-30,-27,-8,-3,-2,0,1,4,8,16,19,20,25℃であった。硬膜外温度の低下に伴い脊髄モニタリングの振幅は減少し冷却終了直後には92.9％(13/14)の個体に異常波形を認めた。硬膜外の復温に伴い9個体で波形は回復し、冷却2時間後に異常波形が残存した個体は28.6％(4/14)であった。冷却2時間後に異常波形が残存した4個体の最低硬膜外温度は全て-8℃以下であり全例で後肢運動障害を認め病理学的検討でも脊髄低温障害の所見を認めた（図2）。一方、冷却2時間後に正常波形であった10個体の最低硬膜外温度は全て-3℃以上であり全例で後肢運動障害を認めなかったが、病理学的検討では最低硬膜外温度が0,1℃の2個体で脊髄低温障害の所見を認めた。イヌを用いた10分間の脊椎cryoablationモデルの検討において最低硬膜外温度が-3℃以上の個体では運動麻痺を生じなかった。しかし病理学的検討では最低硬膜外温度が0,1℃の2個体で脊髄障害の所見を認めたことから、脊髄低温障害をきたす硬膜外温度の臨界点は1-4℃の間と考えられた。本研究の結果より脊椎に対するcryoablationでは手技中の硬膜外温度を4℃以上に保つことで脊髄低温障害を予防しうることが明らかになった。

（図1）実験系の概要

（図2）脊髄低音障害の病理像

（H-E染色、最低硬膜外温度 -8℃）

Chondrocyte-specific inactivation of L-type amino acid transporter 1 results in scoliosis in mice.

マウスにおいてL型アミノ酸輸送体１を軟骨細胞特異的に不活化すると側弯症を呈すHanda M, et al. Spine (Phila Pa 1976). 49:285-293, 2024

小児側弯症の有病率は2-4％といわれており、過去に多くの研究が行われてきたが、未だにその原因に不明である。そのため根治的な治療法はなく、現状は進行抑制を主目的とした装具療法と手術療法に限られている。当研究グループでは、骨格の形成・維持に必要なL型アミノ酸輸送体１（LAT1）の軟骨細胞特異的な不活化による脊柱変形を呈するマウスの作製に成功した（Iwahashi S, et al. J Cell Physiol 2022）。本研究ではLAT１の軟骨細胞特異的不活性化による脊柱変形は臨床の脊柱変形を比してどのような特徴を持つのか、そしてどのように側弯を呈するのかを明らかにすることを目的とした。

Cre-LoxPシステムによりSlc7a5を軟骨細胞特異的にノックアウトすることで、側弯マウス（Skoマウス）を作成し、XpやCT、病理学的な検討を行った。Skoマウスは先天性奇形を伴わず、マウスの成長期（生後1-4週）に脊柱側弯症が進行した（下図）。その脊柱側弯は回旋を伴い多様なカーブパターンを示した。病理学的な検討では軟骨細胞が豊富な椎間板において、成長板の肥厚が確認された（凸側に比べて凹側でより厚く）（Fig.2）。以上の結果からSkoマウスは、臨床における小児側弯症の特徴を有し、特に症候性側弯症に最も類似していた。Skoマウスにおいて、成長板の肥厚つまり軟骨内骨化の障害を認め、軟骨内骨化の障害部位により側弯のカーブパターンが決定されていることが示唆された。

Biomechanical investigation of long spinal fusion models using three-dimensional finite element analysis

三次元有限要素解析法を用いた多椎体脊椎固定モデルにおける応力発生の検討

Oku N, et al. BMC Musculoskeletal Disorders. 24:175, 2023

骨粗鬆症を有する成人脊柱変形に対する矯正固定術のインプラント関連合併症を予防することは重要な課題となっている。一方、脊椎固定術においてどのような条件が合併症抑制に寄与しているか明らかとなっていない。本研究の目的は、三次元有限要素解析法を用いて脊椎矯正固定術を模した胸椎-骨盤までの多椎体脊椎固定モデルに対して、1)脊椎固定範囲、2)固定上端のインプラント種類、3)脊柱矢状面バランス、の3つの脊椎固定条件を変化させた際に発生する応力の変化を検討し、至適な脊椎固定条件を模索した。三次元有限要素解析ソフトを用いて骨粗鬆症患者のCTデータから第１胸椎-骨盤までの骨モデルを構築した。この骨モデルに対して、1)脊椎固定範囲（第2胸椎-骨盤、第10胸椎-骨盤の2通り）、2)固定上端のインプラント種類（椎弓根スクリュー、横突起フックの2通り）、3)脊柱矢状面バランス（Sagittal Vertical Axis：SVA 0mm、50mm、100mmの3通り）を変化させた計12通りの多椎体脊椎固定モデルを作成した。骨盤を完全拘束し、各椎体に荷重を分配し静弾性応力解析を行った。各椎体・インプラントに発生した応力を算出し、脊椎固定条件の違いによる応力の変化を比較した。検討の結果、1)脊椎固定範囲の違いにおける比較：固定上端に発生する応力は、第2胸椎-骨盤モデルより第10胸椎-骨盤モデルの方が大きかった。2)固定上端のインプラント種類の違いにおける比較：第10胸椎-骨盤モデルにおいては、横突起フックよりも椎弓根スクリューを用いた方が固定上端のインプラントに発生する応力が大きかった。3)脊柱矢状面バランスの違いにおける比較：SVAが大きくなるほど、椎体およびインプラントに大きな応力が発生した。特に下位腰椎から骨盤にかけて発生する応力が大きかった。骨粗鬆症を有する成人脊柱変形に対する脊椎矯正固定術後のインプラント関連合併症の発生を抑制するためには、椎体やインプラントに発生する応力を軽減させることが重要である。本研究の結果から、脊椎固定範囲を長くし、固定上端に横突起フックを使用し、脊椎矢状面バランスをSVA 0mmとすることが発生する応力を軽減させ、インプラント関連合併症の発生抑制に寄与する可能性が示唆された。

Tumor-Specific Immunoenhancing Effects after Local Cryoablation for Metastatic Bone Tumor in a Mouse Model

転移性骨腫瘍に対する局所凍結療法のがん特異的免疫増強効果Annen R, et al. Int. J. Mol. Sci. 23:9445, 2022

放射線療法、焼灼療法、塞栓療法、凍結療法（Cryoablation: CA）等の局所療法後に、未治療の遠隔転移巣が縮小する現象が確認されている。腫瘍細胞死が引き金となりがん特異的免疫が賦活化され、未治療の遠隔転移巣が縮小するがん特異的免疫増強効果と考えられており、Abscopal効果と総称される。骨転移治療の分野においてAbscopal効果の基礎研究は少ないため当研究グループでは、マウス転移性骨腫瘍モデルを用いて骨転移巣に対する凍結療法（Cryoablation: CA）によるAbscopal 効果を検証した。さらに、抗PD-1抗体併用によるがん免疫賦活化の相乗効果についても検証した。

マウスの両側脛骨に乳がん細胞を植え込み、骨転移モデルを作成した。左側腫瘍は局所治療としてCAを施行し（Cryoablation tumor: CT）、右側腫瘍は未治療としてAbscopal 効果を評価した（Abscopal tumor: AT）。治療介入として、CAと、抗PD-1抗体腹腔内投与（PD）の2種類を行い、それらの組み合わせにより4群に分けた（Control群、CA群、PD群、CA＋PD群）。ATの経時的な腫瘍サイズ変化、ELISPOT assayによる定量的免疫評価、免疫染色を用いた免疫関連細胞浸潤の強度を比較検討し、各群でAbscopal効果の評価を行った。腫瘍サイズの変化は、7日目ではControl群に比較し、PD群、CA+PD群において有意に縮小傾向を認め、14日目では、Control群に比較し、他の3群全てが有意に縮小傾向を認めた（図1）。ELISPOT assayにおいては、CA群と、CA+PD群において有意にSPOT数の増加を認めた（図2）。免疫染色においてはControl群に比較し、CA群、PD群、CA＋PD群でATへのCD4＋、CD8＋T細胞浸潤は多く、FoxP3細胞浸潤は少ない傾向を認め、癌特異的免疫の増強が示唆された（図3）。マウス骨転移モデルを用いた本研究において、Cryoablation単独による有意な免疫上昇効果が確認された。一部の結果においてCryoablationと抗PD-1抗体の併用による免疫効果の上昇が確認された。

図2.

AT腫瘍サイズの変化

図3. ELISPOT assayの結果

図4 . 免疫染色の結果

● 臨床研究

1. 脊椎腫瘍

脊椎転移に対するTESの適応と意義

Significances and Indications of Total En Bloc Spondylectomy for Spinal Metastases

• Kato S, et al. Cancer Sci. 112:2416-2423, 2021
• Kato S, et al. Bone Joint J. 105-B:575-582, 2023
• Kato S, et al. Eur Spine J. 29:3237-3244, 2020
• Kato S, et al. J Orthop Sci. 29:908-913, 2024
• Kato S, et al. Oncologist. 26:e1833-e1843, 2021

当科で開発された腫瘍脊椎骨全摘術（Total en bloc spondylectomy: TES）は、脊椎腫瘍の局所根治を可能とする画期的な手術であり、根治的切除が望ましい原発性腫瘍（Aggressive beningもしくはmalignant）に対する適応に関しては異論がない。しかし、進行がん患者が対象となる転移性脊椎腫瘍に対する適応、有用性は明確に示されてこなかった。当科の研究（長期成績の検討）および各種がんにおける骨転移の特徴、診療ガイドラインの内容などを踏まえると、腎癌・甲状腺癌・低悪性肉腫の孤立性脊椎転移がTESの良い適応であることが明らかとなっている【1-3】。これらの骨転移は、転移巣のFirst Line治療や放射線治療に抵抗性であり、骨破壊性で病的骨折や麻痺などのPerformance statusを低下させる症状を来しやすいという特徴がある。これらのがん種の孤立性脊椎転移に対するTESは、手術時に全身治療や外科的切除で制御可能な肺転移があっても臨床成績が良好であることが示されている【1-3】。それに加えて肺癌【4】や乳癌の症候性の孤立性脊椎転移に対しても、当科では厳密に症例を選択することで良好な成績を得ている。各種がん種の孤立性脊椎転移に対するTESの長期成績において、術後PS不良が共通した予後不良因子であった【1-4、下図】。術後の麻痺や創部感染、早期再発といった術後合併症が術後PS不良に直結し、有効な全身治療の機会を妨げることで生命予後にも間接的に影響する。したがって、合併症を少なくTESを実施することが、脊椎転移に対してTESを適応する上での重要な因子であり、脊椎転移に対する根治的切除の臨床成績や意義を高めることになる。

上記の内容を踏まえ、当科では脊椎転移に対する根治的手術の適応、手術手技、臨床成績や意義をまとめた総説を発表している【5】。

TESの術後合併症とその対策Postperative Complications of Total En Bloc Spondylectomy and Their Countermeasures

【1】    Demura S, et al. Bone Joint J. 103-B:976-983, 2021

【2】    Yokogawa N, et al. Orthopedics. 38:e561-566, 2015

【3】    Yokogawa N, et al. Spine J. 18:381-386, 2018

【4】    Kurokawa Y, et al. Spinal Cord. 58:900-907, 2020

【5】    Hayashi H, et al. Spine J. 15:132-137, 2015

•  Kawai M, et al. J Clin Med. 12:4168, 2023
•  Yokogawa N, et al. PLoS One. 9:e98797, 2014
•  Shimizu T, et al. Bone Joint J. 105-B:172-179, 2023
•  Yoshioka K, et al. Spine Surg Relat Res. 1:31-39, 2017
•  Shinmura K, et al. Spine Surg Relat Res. 7:60-65, 2023
•  Shinmura K, et al. BMC Musculoskelet Disord. 2020;21:591, 2023

TESは、難易度が高く手術侵襲も大きいため周術期合併症のリスクが高い。当院でTESを施行した300例以上を対象とした解析では、合併症発生率はmajor complication 39.7%、minor complication 27.4%であった【1】。内訳としてはinstrumentation failure(IF)が最多で、出血、呼吸器合併症、硬膜損傷・髄液漏【2,3】、神経合併症【4】、手術部位感染【5】がそれに続き（図1）、術前放射線照射やフレイルを有する例では合併症リスクが高かった【6,7】。TES後のIFはロッド折損が大部分で、術後2−3年の発生が多かった。腰椎レベルや多椎間のTES、術前放射線照射、術後早期のケージ沈み込み、液体窒素処理骨の単独移植がリスク因子と判明し【8,9】、これらを踏まえ、TES後の脊柱再建に用いるケージやロッドを強固なものとし、移植骨方法を改良することで最近のIF発生率は4%と著明に減少している【10】。また、IF後の再手術は後方単独アプローチで、scar membraneに十分な骨移植を行うことにより全例で骨癒合を得ている【11】（図2）。

図1．TES後の周術期合併症（文献1より引用）

図2．TES後instrumentation failureとrevision surgery（文献11より引用）

脊椎腫瘍手術における放射線照射の影響

Effects of Radiation in Spinal Tumor Surgery

【1】    Yokogawa N, et al. PLoS ONE. 9:e109838, 2014

【2】    Yokogawa N, et al. PLoS ONE. 10:e0133806, 2015

【3】    Igarashi T, et al. Spine (Phila Pa 1976). 47:E514-E520, 2022

【4】    Shimizu T, et al. Clin Orthop Relat Res. 479:163-176, 2021

【5】    Yokogawa N, et al. J Clin Med. 12:4603, 2023

TESは、その侵襲性の大きさから周術期合併症のリスクが非常に高いことが知られている。特に、既に放射線治療が行われた部位での手術では、従来から創治癒遅延や創部感染が起こりやすいとされており、さらに当科でのTESの臨床経験から、硬膜損傷や髄液漏といった脊椎特有の合併症が発生しやすくなることが明らかとなった【1】。

こうした背景を踏まえ、当科では放射線照射が脊椎およびその周囲組織に与える影響に関する基礎研究を行ってきた。まず、放射線照射モデルマウスを用いた研究では、照射線量に依存して硬膜外腔の線維化が生じること、さらにクモ膜バリア細胞層が菲薄化することを確認した【2】。硬膜外腔の線維化は癒着を引き起こし、クモ膜バリア細胞層の菲薄化は髄膜透過性の亢進につながる。また、放射線照射モデルラットを用いた研究では、照射による骨微細構造の劣化とそれに伴う骨強度の低下が確認され、これらはインプラントの緩みや脱転、骨癒合不全をもたらす可能性がある【3】。さらに、腫瘍脊髄圧迫モデルマウスでは、照射によって硬膜バリア機構が破綻し、腫瘍の硬膜内浸潤が起こりやすくなることを明らかにした【4】。実際に、当科でのTESの治療成績をまとめた最近の比較研究においても、放射線治療の既往がある患者では周術期合併症のリスクが増加し（合併症発生率：57.1％対35.7％）、術後の局所再発リスクも高まることが示された（局所再発率　術後2年：20.8％対2.9％、5年：24.4％対6.9％）【5】。これらの研究成果は、脊椎腫瘍の治療方針を決定するうえで大変重要な知見であり、放射線照射の既往がTESの周術期合併症や局所制御に及ぼす影響を十分に考慮し、適切な治療選択を行う必要があることを示唆している。さらに、こうした脊椎およびその周囲組織に生じる放射線障害の予防に向けて、現在新たな基礎研究を進めている。

　　　2. 　脊柱変形

小児脊柱変形手術における治療戦略および術後経過に関する検討

Surgical Strategy and Clinical Course for Pediatric Spine Deformity

【1】    Demura S, et al. Spine. 38:1920-1926, 2013

【2】    Demura S, et al. Spine. 38:E649-E655, 2013

【3】    Demura S, et al. Spine Deform. 1:46-50 2013

【4】    Demura S, et al. Spine J. 16:1152-1156, 2016

【5】    Demura S, et al. Spine Surg Relat Res. 1:27-30, 2017

【6】    Demura S, et al. Global Spine J. 10:433-437, 2019

【7】    Demura S, et al. J Neurosurg Spine. 38:192-198, 2022

【8】    Yokogawa N, et al. BMC Musculoskelet Disord. 25:115, 2024

小児脊柱側弯症は、三次元的な回旋変形とともに脊柱が側方に弯曲する成長期の代表的疾患のひとつである。側弯症の変形の程度や種類は様々であり、経過観察のみの症例、装具治療を必要とする症例、手術治療が必要となる症例にわかれる。そのなかで小児脊柱変形の手術治療は、近年の手術技術の向上や医療機器の発展に伴い、より安全で、より効果的な脊柱変形矯正が可能となってきている。当科では特発性側弯症を中心に、矯正固定範囲を可能な限り短縮する選択的固定を第一に考え治療計画を立てている。これに関連して、矯正固定範囲と非固定部位の体幹バランスや隣接椎間の問題、脊椎インストメントに関する合併症、呼吸機能への影響、そして低侵襲かつ効果的な矯正手技に関する研究を行っている。

小児脊柱変形治療における放射線被ばく低減への取り組み

Reduction of Radiation Exposure in the Treatment of Pediatric Spinal Deformity

【1】    Minehiro K, et al. Spine 44:203-210 2019小児脊柱変形症例に対する治療においては、経過観察、装具治療、手術治療のいずれにおいても、全脊柱単純X線撮影による定期的評価や、時にはCTによる精査が必要となる。そのため、幼少期から思春期にかけて、多数回の撮影による放射線被ばくの増加が懸念される。以前より小児単純X線撮影に対しては、撮影ポジションの違いや防護具の併用による被ばく低減の検討がなされてきた。また通常の単純X線では連続スペクトルを用いた撮影が一般的であり、低エネルギー部分のX線の大部分が被写体に吸収され、被ばくの線量の増加につながっていた。当科では既存のX線画像診断装置を用いた低線量化の試み【1】に加え、CTに関しても、臓器への被ばくに配慮した撮影プロトコルの導入を試みている。

当院における低線量全脊柱X線

当院における低線量CT

　　　3. 　胸椎OPLL

胸椎OPLLに対する後側方進入前方除圧術

Anterior Spinal Cord Decompression via a Posterolateral Approach for the Treatment of Ossification of the Posterior Longitudinal Ligament in the Thoracic Spine

【1】    Kato S, et al. J Neurosurg Spine. 17:525-529, 2012

【2】    Kato S, et al. J Neurosurg Spine. 23:479-483, 2015

【3】    Kato S, et al. Eur Spine J. 29:113-121, 2020

後弯を有する胸椎の後縦靱帯骨化症（OPLL）において、骨化形態や局所アライメントによって脊髄前方除圧（骨化の浮上もしくは切除）が望ましい症例が存在することは論理的に疑いようがない。しかし、胸椎OPLLに対する前方除圧術は、前方進入、後方進入のアプローチにかかわらず難易度の高い手術であり、術後の麻痺増悪などの手術合併症の問題により、これまでごく限られた施設で実施され、標準的な手術として発展してこなかった。我々は胸椎OPLLに対する脊髄前方除圧術において、安全かつ確実なOPLLの浮上を可能にする後側方アプローチによる前方除圧術を2010年に考案し、2012年に論文発表をしている【1】。近年では多くの施設で追試され、その有用性を実感している脊椎外科医も多い。従来の後方進入前方除圧術（大塚法）と異なる本術式の最も重要なポイントは、脊髄前方除圧（骨化浮上）を安全かつ確実に実施するための脊髄後側方部におけるspace creationであり、これが本術式を後側方進入前方除圧術と定義している所以である【2,3】。この特徴・メリットを達成するための手技は、①横突起と椎弓根の切除による硬膜管後側方のワーキングスペースと視野の確保、②神経根の切離、近位端を持ち上げることによるOPLL頭尾側の横切部のワーキングスペースと視野の確保である。これらの手技は、術野の出血コントロールにも大きく寄与し、大塚法とは全く異なるクリアで広い術野とワーキングスペースを提供する（下図）。特に基本手技である横突起と椎弓根の切除は、国内外で近年発表されている脊髄前方除圧術でも採用されている方法であり、胸椎OPLLに対する脊髄前方除圧が近年に発展・拡大したポイントといえる。当院では、beak-type OPLLに代表される責任高位が限局し大きなOPLL（脊柱管占拠率50％以上）が後弯胸椎に存在する場合は後側方進入による脊髄前方除圧の適応とし、それ以外は後方除圧固定を原則としている【3】。近年は多くの脊椎外科医の手術見学を受け入れ、他院での出張手術も実施して、胸椎OPLLに対する前方除圧術の発展に寄与している。

1. 体幹機能評価、慢性腰痛・ロコモの運動療法

慢性腰痛やロコモの患者に適した体幹運動器具RECORE（リコア）の開発

Innovative Exercise Device for the Patients with Chronic Low Back Pain and/or Locomotive Syndrome

【1】    Kato S, et al. PLoS One. 12:e0172934, 2017

【2】    Kato S, et al. J Back Musculoskelet Rehabili. 33:677-684, 2020

【3】    Kurokawa Y, et al. J Back Musculoskelet Rehabili. 35:589-596, 2022

【4】    Kato S, et al. BMC Musculoskelet Disord. 20:273, 2019

【5】    Kato S, et al. J Clin Med. 11:4868, 2022

【6】    Kato S, et al. Ann Rehabil Med. 44:246-255, 2020

【7】    Kitagawa R, et al. Sci Rep. 10:21883, 2020

慢性腰痛に対する運動療法はエビデンスの高い治療であるが、アドヒアランスが低く、広く普及しているとは言いがたい。特に中高齢者の腰痛患者は、強い痛みや脊柱変形、筋力低下などにより、継続して実施できる運動（特に筋力強化）は限定的である。当科で開発したRECORE®（リコア）は、腹部に巻き付けたベルト状膨隆体（カフ）を押しかえすように腹部に力を入れ込むことで腹部体幹筋の筋力測定やトレーニングができる運動器具である【1】。この筋力測定やトレーニングは、坐位で体幹を動かさずに実施できるため腰痛を有する患者や高齢者に最適なデザインであり、慢性腰痛やロコモに対する新たな運動アプローチ、体幹機能評価ツールとして期待できる。RECORE®を用いて行うトレーニングでは、表層筋である腹直筋や腹斜筋だけでなく、深層筋の横隔膜や腹横筋、骨盤底筋にも強い筋活動が生じることが示されている【2,3】。これらの筋群は、コアを呼ばれる腹腔を取り囲むMuscular Boxを形成し、腹圧の調節や安定化に寄与して体幹を支持する機能を持つ。当科で実施した臨床研究では、RECORE®で測定する腹部体幹筋力の低下が中高齢者の慢性腰痛やロコモだけでなく【4】、将来的な骨粗鬆症性椎体骨折の発生にも影響する可能性が示唆され【5】、介入研究において腹部体幹筋強化による慢性腰痛やロコモの改善効果が示されている【6,7】。RECORE®は現在、多くの病院やクリニックにおいて慢性腰痛やロコモ患者のリハビリテーションとして臨床診療で使用されているだけでなく、大学などの研究機関でも体幹機能を評価する目的で研究にも使用されている。

　　　5. 　ロコモ研究

運動器変性疾患に対する手術のロコモ及び運動機能改善効果The Efficacy of Surgical Treatment on Locomotive Syndrome and Physical Function in Patients with Degenerative Musculoskeletal Diseases

• Kato S, et al. BMC Musculoskelet Disord. 21:515,2020
• Kato S, et al. Mod Rheumatol. 32:822-829, 2022
• Kato S, et al. Mod Rheumatol. 33:836-842, 2023
• Shimizu T, et al. J Orthop Sci. 26:327-331, 2021
• Nagatani S, et al. J Clin Med. 11:5179, 2022

国民の健康寿命延伸に向けて、日本整形外科学会がロコモティブシンドローム（ロコモ）の概念を提唱した。ロコモは運動器の障害により要介護になるリスクの高い状態とされ、主な原因疾患は脊椎・下肢関節の加齢性変性疾患である。当院ではこれらの疾患で手術を実施した患者において術前後のロコモを含む詳細な運動機能を評価する多施設前向き研究を先駆けて行ってきた。

脊椎・下肢変性疾患（腰椎、股関節、膝関節、足関節・足部）手術症例の約9割以上が術前評価で旧基準で最も重症なロコモ度2と判定され、4割の症例が術後にロコモ度が改善した。より重症なロコモ症例を適切に評価できるようにロコモ度3の設定するのが望ましいことを提唱した【1】。ロコモ度3を含む新基準が日本整形外科学会から発表されたことにより、手術症例におけるロコモ新基準の妥当性を検証した。ロコモ25は単独でも手術症例のロコモ度をよく反映していることを明らかにした【2】。65歳以上、術前ロコモ度3の症例を対象とした研究では、後期高齢者（75歳以上）における手術のロコモ改善効果は限定的であること、ロコモ改善の阻害因子は高齢、肥満、低握力（サルコペニア）、フレイルであることを示した【3】。腰部脊柱管狭窄症に対象を絞った研究では、手術予定の患者は全例がロコモと診断され、その過半数が最も重症なロコモ度3に該当していた。手術により多くの運動機能が改善されることが確認されたが、立ち上がりテストの改善は限定的で、全体のロコモ度の改善の障害となる例が散見された。リスク因子解析では、ロコモ度改善の阻害因子として再手術例や75歳以上、馬尾型の神経障害、術後の矢状面バランス不良などが挙げられた【4】。股関節OAに対するTHAでは、股関節の屈曲拘縮が改善するため全脊柱の矢状面アライメントは術後に改善するが、術後の経過で悪化する症例が散見され、臨床において問題となる。そのアライメント悪化のリスク因子が術前の腹部体幹筋力とSacral Slopeの低値であることを縦断研究で示した【5】。

業績

英語論文（2010～）

2024年

Yokogawa N, Demura S, Ohara T, Tauchi R, Takimura K, Yanagida H, Yamaguchi T, Watanabe K, Suzuki S, Uno K, Suzuki T, Watanabe K, Kotani T, Nakayama K, Oku N, Taniguchi Y, Murakami H, Yamamoto T, Kawamura I, Takeshita K, Sugawara R, Kikkawa I, Kawakami N. Instrumentation failure following pediatric spine deformity growth-sparing surgery using traditional growing rods or vertical expandable prosthetic titanium ribs. BMC Musculoskelet Disord. 25(1):115, 2024

Handa M, Demura S, Yokogawa N, Hinoi E, Hiraiwa M, Kato S, Shinmura K, Annen R, Kobayashi M, Yamada Y, Nagatani S, Kurokawa Y, Tsuchiya H. Characteristics of Scoliosis in Mice Induced by Chondrocyte-specific Inactivation of L-type Amino Acid Transporter 1. Spine (Phila Pa 1976). 49(4):285-293, 2024

Kobayashi M, Kato S, Demura S, Yokogawa N, Yokka A, Nakade Y, Annen R, Gabata T, Tsuchiya H. Evaluation of Conditions for the Development of Cryogenic Spinal Cord Injury Using a Canine Model: An Experimental Study on the Safety of Cryoablation for Metastatic Spinal Tumors. AJNR Am J Neuroradiol. 2024 Mar 7. Online ahead of print. doi: 10.3174/ajnr.A8151.

Nanpo K, Toribatake Y, Yonezawa N, Kato S, Shinmura K, Demura S, Tsuchiya H. Cervical intradural disc herniation in a patient with cervical ossification of the posterior longitudinal ligament: a case report and review of the literature. J Orthop Sci. 29(1):434-438, 2024

Nori S, Watanabe K, Takeda K, Yamane J, Kono H, Yokogawa N, Sasagawa T, Ando K, Nakashima H, Segi N, Funayama T, Eto F, Yamaji A, Furuya T, Yunde A, Nakajima H, Yamada T, Hasegawa T, Terashima Y, Hirota R, Suzuki H, Imajo Y, Ikegami S, Uehara M, Tonomura H, Sakata M, Hashimoto K, Onoda Y, Kawaguchi K, Haruta Y, Uei H, Sawada H, Nakanishi K, Misaki K, Terai H, Tamai K, Shirasawa E, Inoue G, Kiyasu K, Iizuka Y, Takasawa E, Funao H, Kaito T, Yoshii T, Ishihara M, Okada S, Imagama S, Kato S. Influence of the timing of surgery for cervical spinal cord injury without bone injury in the elderly: A retrospective multicenter study. J Orthop Sci. 29(2):480-485, 2024

Hirota R, Terashima Y, Ohnishi H, Yamashita T, Yokogawa N, Sasagawa T, Ando K, Nakashima H, Segi N, Funayama T, Eto F, Yamaji A, Watanabe K, Yamane J, Takeda K, Furuya T, Yunde A, Nakajima H, Yamada T, Hasegawa T, Suzuki H, Imajo Y, Ikegami S, Uehara M, Tonomura H, Sakata M, Hashimoto K, Onoda Y, Kawaguchi K, Haruta Y, Suzuki N, Kato K, Uei H, Sawada H, Nakanishi K, Misaki K, Terai H, Tamai K, Shirasawa E, Inoue G, Kakutani K, Kakiuchi Y, Kiyasu K, Tominaga H, Tokumoto H, Iizuka Y, Takasawa E, Akeda K, Takegami N, Funao H, Oshima Y, Kaito T, Sakai D, Yoshii T, Ohba T, Otsuki B, Seki S, Miyazaki M, Ishihara M, Okada S, Imagama S, Kato S. Prognostic Factors for Respiratory Dysfunction for Cervical Spinal Cord Injury and/or Cervical Fractures in Elderly Patients: A Multicenter Survey. Global Spine J. 14(1):101-112, 2024

Tamai K, Terai H, Nakamura H, Yokogawa N, Sasagawa T, Nakashima H, Segi N, Ito S, Funayama T, Eto F, Yamaji A, Watanabe K, Yamane J, Takeda K, Furuya T, Yunde A, Nakajima H, Yamada T, Hasegawa T, Terashima Y, Hirota R, Suzuki H, Imajo Y, Ikegami S, Uehara M, Tonomura H, Sakata M, Hashimoto K, Onoda Y, Kawaguchi K, Haruta Y, Suzuki N, Kato K, Uei H, Sawada H, Nakanishi K, Misaki K, Kuroda A, Inoue G, Kakutani K, Kakiuchi Y, Kiyasu K, Tominaga H, Tokumoto H, Iizuka Y, Takasawa E, Akeda K, Takegami N, Funao H, Oshima Y, Kaito T, Sakai D, Yoshii T, Ohba T, Otsuki B, Seki S, Miyazaki M, Ishihara M, Okada S, Imagama S, Kato S. Impact of malnutrition on mortality and neurological recovery of older patients with spinal cord injury. Sci Rep. 11;14(1):5853, 2024.

Tamai K, Terai H, Nakamura H, Yokogawa N, Sasagawa T, Nakashima H, Segi N, Ito S, Funayama T, Eto F, Yamaji A, Watanabe K, Yamane J, Takeda K, Furuya T, Yunde A, Nakajima H, Yamada T, Hasegawa T, Terashima Y, Hirota R, Suzuki H, Imajo Y, Ikegami S, Uehara M, Tonomura H, Sakata M, Hashimoto K, Onoda Y, Kawaguchi K, Haruta Y, Suzuki N, Kato K, Uei H, Sawada H, Nakanishi K, Misaki K, Kuroda A, Inoue G, Kakutani K, Kakiuchi Y, Kiyasu K, Tominaga H, Tokumoto H, Iizuka Y, Takasawa E, Akeda K, Takegami N, Funao H, Oshima Y, Kaito T, Sakai D, Yoshii T, Ohba T, Otsuki B, Seki S, Miyazaki M, Ishihara M, Okada S, Imagama S, Kato S. Neurological recovery rate and predictive factors of incomplete AIS grade C spinal cord injury in the older aged population. Spinal Cord. 2024 Feb 12. Online ahead of print. doi: 10.1038/s41393-024-00963-0.

Segi N, Nakashima H, Ito S, Yokogawa N, Sasagawa T, Watanabe K, Nori S, Funayama T, Eto F, Nakajima H, Terashima Y, Hirota R, Hashimoto K, Onoda Y, Furuya T, Yunde A, Ikegami S, Uehara M, Suzuki H, Imajo Y, Uei H, Sawada H, Kawaguchi K, Nakanishi K, Suzuki N, Oshima Y, Hasegawa T, Iizuka Y, Tonomura H, Terai H, Akeda K, Seki S, Ishihara M, Inoue G, Funao H, Yoshii T, Kaito T, Kiyasu K, Tominaga H, Kakutani K, Sakai D, Ohba T, Otsuki B, Miyazaki M, Murotani K, Okada S, Imagama S, Kato S. Early Versus Delayed Surgery for Elderly Traumatic Cervical Spinal Injury: A Nationwide Multicenter Study in Japan. Global Spine J. 2024 Jan 16 Online ahead of print. doi: 10.1177/21925682241227430.

Abe K, Kawase H, Yokogawa N, Yamashita K, Yamashita M, Sasaki T, Yamaoka A, Shiga Y, Maki S, Inage K, Eguchi Y, Orita S, Ohtori S. Mapping the Japanese orthopedic association national registry (JOANR) to the international classification of health interventions (ICHI). J Orthop Sci. 29(2):675-680, 2024

2023年

Demura S, Kato S, Yoshioka K, Shinmura K, Yokogawa N, Shimizu T, Annen R, Kobayashi M, Yamada Y, Nagatani S, Kurokawa Y, Murakami H, Tsuchiya H. The influence of costal resection on pulmonary function after total en bloc spondylectomy for spine tumor. J Orthop Sci. 28(5):972-975, 2023

Kato S, Demura S, Kabata T, Matsubara H, Kurokawa Y, Okamoto Y, Kuroda K, Kajino Y, Yokogawa N, Inoue D, Tsuchiya H. Risk Factors that Hinder Locomotive Syndrome Improvement Following Surgery for Musculoskeletal Diseases in Older Patients: A Multicenter Prospective Study. Mod Rheumatol. 33(4):836-842, 2023

Kato S, Demura S, Kitagawa R, Yokogawa N, Shimizu T, Kobayashi M, Yamada Y, Nagatani S, Murakami H, Kawahara N, Tsuchiya H. Clinical outcomes following total en bloc spondylectomy for spinal metastases from lung cancer. J Orthop Sci. 2023 May 4:S0949-2658(23)00125-2. Online ahead of print.

Kato S, Demura S, Yokogawa N, Shimizu T, Kobayashi M, Yamada Y, Murakami H, Tsuchiya H. Metastasectomy of spinal lesions from thyroid carcinomas. Bone Joint J. 105-B(5):575-582, 2023

Kato S, Demura S, Shinmura K, Yokogawa N, Murakami H. Reply to the Editor Regarding the Article: A Modified Spinal Reconstruction Method Reduces Instrumentation Failure in Total En Bloc Spondylectomy for Spinal Tumors. Spine Surg Relat Res. 7(6):561-562, 2023

Yokogawa N, Kato S, Shimizu T, Kurokawa Y, Kobayashi M, Yamada Y, Nagatani S, Kawai M, Uto T, Murakami H, Kawahara N, Demura S. Clinical Outcomes of Total En Bloc Spondylectomy for Previously Irradiated Spinal Metastases: A Retrospective Propensity Score-Matched Comparative Study. J Clin Med. 2(14):4603, 2023

Shimizu T, Kato S, Demura S, Shinmura K, Yokogawa N, Kurokawa Y, Yoshioka K, Murakami H, Kawahara N, Tsuchiya H. Characteristics and risk factors of instrumentation failure following total en bloc spondylectomy. Bone Joint J. 105-B(2):172-179, 2023

Oku N, Demura S, Tawara D, Kato S, Shinmura K, Yokogawa N, Yonezawa N, Shimizu T, Kitagawa R, Handa M, Ryohei A, Tsuchiya H. Biomechanical investigation of long spinal fusion models using three-dimensional finite element analysis. BMC Musculoskelet Disord. 24(1):175, 2023

Handa M, Kato S, Sakurai G, Yabe T, Demura S, Takeshita Y, Kanamori T, Nakano Y, Shinmura K, Yokogawa N, Kashihara N, Yahata T, Takamura T, Tsuchiya H. Prevalence of locomotive syndrome and its associated factors in patients with type 2 diabetes mellitus. Mod Rheumatol. 33(2):422-427, 2023

Kobayashi M, Yokogawa N, Kato S, Sasagawa T, Tsuchiya H, Nakashima H, Segi N, Ito S, Funayama T, Eto F, Yamaji A, Yamane J, Nori S, Furuya T, Yunde A, Nakajima H, Yamada T, Hasegawa T, Terashima Y, Hirota R, Suzuki H, Imajo Y, Ikegami S, Uehara M, Tonomura H, Sakata M, Hashimoto K, Onoda Y, Kawaguchi K, Haruta Y, Suzuki N, Kato K, Uei H, Sawada H, Nakanishi K, Misaki K, Terai H, Tamai K, Kuroda A, Inoue G, Kakutani K, Kakiuchi Y, Kiyasu K, Tominaga H, Tokumoto H, Iizuka Y, Takasawa E, Akeda K, Takegami N, Funao H, Oshima Y, Kaito T, Sakai D, Yoshii T, Ohba T, Otsuki B, Seki S, Miyazaki M, Ishihara M, Okada S, Imagama S, Watanabe K. Risk Factors for Early Mortality in Older Patients with Traumatic Cervical Spine Injuries-A Multicenter Retrospective Study of 1512 Cases. J Clin Med. 12(2):708, 2023

Yamada Y, Yokogawa N, Kato S, Sasagawa T, Tsuchiya H, Nakashima H, Segi N, Ito S, Funayama T, Eto F, Yamaji A, Yamane J, Nori S, Furuya T, Yunde A, Nakajima H, Yamada T, Hasegawa T, Terashima Y, Hirota R, Suzuki H, Imajo Y, Ikegami S, Uehara M, Tonomura H, Sakata M, Hashimoto K, Onoda Y, Kawaguchi K, Haruta Y, Suzuki N, Kato K, Uei H, Sawada H, Nakanishi K, Misaki K, Terai H, Tamai K, Kuroda A, Inoue G, Kakutani K, Kakiuchi Y, Kiyasu K, Tominaga H, Tokumoto H, Iizuka Y, Takasawa E, Akeda K, Takegami N, Funao H, Oshima Y, Kaito T, Sakai D, Yoshii T, Ohba T, Otsuki B, Seki S, Miyazaki M, Ishihara M, Okada S, Imagama S, Watanabe K. Effects of Dementia on Outcomes after Cervical Spine Injuries in Elderly Patients: Evaluation of 1512 Cases in a Nationwide Multicenter Study in Japan. J Clin Med. 12(5):1867, 2023

Kawai M, Demura S, Kato S, Yokogawa N, Shimizu T, Kurokawa Y, Kobayashi M, Yamada Y, Nagatani S, Uto T, Murakami H. The Impact of Frailty on Postoperative Complications in Total En Bloc Spondylectomy for Spinal Tumors. J Clin Med.12(12):4168, 2023

Ng YH, Kato S, Demura S, Shinmura K, Yokogawa N, Nakade Y, Yonezawa N, Shimizu T, Tsuchiya H. Delayed ischemic spinal cord injury after total en bloc spondylectomy in the thoracic spine. J Orthop Sci. 28(5):1179-1183, 2023

Asano Y, Yamamoto N, Demura S, Hayashi K, Takeuchi A, Kato S, Miwa S, Igarashi K, Higuchi T, Taniguchi Y, Morinaga S, Sone T, Okuda M, Matsumoto I, Yano S, Tsuchiya H. Novel predictors of immune checkpoint inhibitor response and prognosis in advanced non-small-cell lung cancer with bone metastasis. Cancer Med. 12(11):12425-12437, 2023

Otomo N, Khanshour AM, Koido M, Takeda K, Momozawa Y, Kubo M, Kamatani Y, Herring JA, Ogura Y, Takahashi Y, Minami S, Uno K, Kawakami N, Ito M, Sato T, Watanabe K, Kaito T, Yanagida H, Taneichi H, Harimaya K, Taniguchi Y, Shigematsu H, Iida T, Demura S, Sugawara R, Fujita N, Yagi M, Okada E, Hosogane N, Kono K, Nakamura M, Chiba K, Kotani T, Sakuma T, Akazawa T, Suzuki T, Nishida K, Kakutani K, Tsuji T, Sudo H, Iwata A, Inami S, Wise CA, Kochi Y, Matsumoto M, Ikegawa S, Watanabe K, Terao C. Evidence of causality of low body mass index on risk of adolescent idiopathic scoliosis: a Mendelian randomization study. Front Endocrinol (Lausanne). 14:1089414, 2023

Li Y, Katayama Y, Nie I, Nakano T, Sawaragi E, Sakamoto M, Yamanaka H, Tsuge I, Demura S, Yamada Y, Tsuchiya H, Morimoto N. Development of a novel regenerative therapy for malignant bone tumors using an autograft containing tumor inactivated by high hydrostatic pressurization (HHP). Regen Ther. 22:224-231, 2023

Yonezawa Y, Guo L, Kakinuma H, Otomo N, Yoshino S, Takeda K, Nakajima M, Shiraki T, Ogura Y, Takahashi Y, Koike Y, Minami S, Uno K, Kawakami N, Ito M, Yonezawa I, Watanabe K, Kaito T, Yanagida H, Taneichi H, Harimaya K, Taniguchi Y, Shigematsu H, Iida T, Demura S, Sugawara R, Fujita N, Yagi M, Okada E, Hosogane N, Kono K, Chiba K, Kotani T, Sakuma T, Akazawa T, Suzuki T, Nishida K, Kakutani K, Tsuji T, Sudo H, Iwata A, Sato T, Inami S, Nakamura M, Matsumoto M, Terao C, Watanabe K, Okamoto H, Ikegawa S. Identification of a Functional Susceptibility Variant for Adolescent Idiopathic Scoliosis that Upregulates Early Growth Response 1 (EGR1)-Mediated UNCX Expression. J Bone Miner Res. 38(1):144-153, 2023

Koike Y, Takahata M, Nakajima M, Otomo N, Suetsugu H, Liu X, Endo T, Imagama S, Kobayashi K, Kaito T, Kato S, Kawaguchi Y, Kanayama M, Sakai H, Tsuji T, Miyamoto T, Inose H, Yoshii T, Kashii M, Nakashima H, Ando K, Taniguchi Y, Takeuchi K, Ito S, Tomizuka K, Hikino K, Iwasaki Y, Kamatani Y, Maeda S, Nakajima H, Mori K, Seichi A, Fujibayashi S, Kanchiku T, Watanabe K, Tanaka T, Kida K, Kobayashi S, Takahashi M, Yamada K, Takuwa H, Lu HF, Niida S, Ozaki K, Momozawa Y; Genetic Study Group of Investigation Committee on Ossification of the Spinal Ligaments; Yamazaki M, Okawa A, Matsumoto M, Iwasaki N, Terao C, Ikegawa S. Genetic insights into ossification of the posterior longitudinal ligament of the spine. Elife. 12:e86514, 2023

Matsukura Y, Egawa S, Inose H, Sakai K, Kusano K, Tsutsui S, Hirai T, Wada K, Katsumi K, Koda M, Kimura A, Furuya T, Maki S, Nagoshi N, Nishida N, Nagamoto Y, Oshima Y, Ando K, Nakashima H, Takahata M, Mori K, Nakajima H, Murata K, Miyagi M, Kaito T, Yamada K, Banno T, Kato S, Ohba T, Moridaira H, Fujibayashi S, Katoh H, Kanno H, Taneichi H, Imagama S, Kawaguchi Y, Takeshita K, Nakamura M, Matsumoto M, Yamazaki M, Okawa A, Yoshii T. Preoperative Symptom Duration Influences Neurological Recovery and Patient-Reported Outcome Measures After Surgical Treatment of Cervical Ossification of the Posterior Longitudinal Ligament. Spine (Phila Pa 1976). 48(18):1259-1265, 2023

Miyagi M, Inoue G, Yoshii T, Egawa S, Sakai K, Kusano K, Nakagawa Y, Hirai T, Wada K, Katsumi K, Kimura A, Furuya T, Nagoshi N, Kanchiku T, Nagamoto Y, Oshima Y, Nakashima H, Ando K, Takahata M, Mori K, Nakajima H, Murata K, Matsunaga S, Kaito T, Yamada K, Kobayashi S, Kato S, Ohba T, Inami S, Fujibayashi S, Katoh H, Kanno H, Koda M, Takahashi H, Ikeda S, Imagama S, Kawaguchi Y, Takeshita K, Matsumoto M, Takaso M, Okawa A, Yamazaki M. Residual Neuropathic Pain in Postoperative Patients With Cervical Ossification of Posterior Longitudinal Ligament. Clin Spine Surg. 36(6):E277-E282, 2023

Nakashima H, Imagama S, Yoshii T, Egawa S, Sakai K, Kusano K, Tsutsui S, Hirai T, Matsukura Y, Wada K, Katsumi K, Koda M, Kimura A, Furuya T, Maki S, Nagoshi N, Nishida N, Nagamoto Y, Oshima Y, Ando K, Takahata M, Mori K, Nakajima H, Murata K, Miyagi M, Kaito T, Yamada K, Banno T, Kato S, Ohba T, Moridaira H, Fujibayashi S, Katoh H, Kanno H, Taneichi H, Kawaguchi Y, Takeshita K, Nakamura M, Okawa A, Yamazaki M. Factors Associated With Loss of Cervical Lordosis After Laminoplasty for Patients With Cervical Ossification of the Posterior Longitudinal Ligament: Data From a Prospective Multicenter Study. Spine (Phila Pa 1976). 48(15):1047-1056, 2023

Nagoshi N, Yoshii T, Egawa S, Sakai K, Kusano K, Tsutsui S, Hirai T, Matsukura Y, Wada K, Katsumi K, Koda M, Kimura A, Furuya T, Sato Y, Maki S, Nishida N, Nagamoto Y, Oshima Y, Ando K, Nakashima H, Takahata M, Mori K, Nakajima H, Murata K, Miyagi M, Kaito T, Yamada K, Banno T, Kato S, Ohba T, Moridaira H, Fujibayashi S, Katoh H, Kanno H, Watanabe K, Taneichi H, Imagama S, Kawaguchi Y, Takeshita K, Nakamura M, Matsumoto M, Yamazaki M. Comparison of Surgical Outcomes of Anterior and Posterior Fusion Surgeries for K-line (-) Cervical Ossification of the Posterior Longitudinal Ligament: A Prospective Multicenter Study. Spine (Phila Pa 1976). 48(13):937-943, 2023

Ito S, Nakashima H, Yoshii T, Egawa S, Sakai K, Kusano K, Tsutui S, Hirai T, Matsukura Y, Wada K, Katsumi K, Koda M, Kimura A, Furuya T, Maki S, Nagoshi N, Nishida N, Nagamoto Y, Oshima Y, Ando K, Takahata M, Mori K, Nakajima H, Murata K, Miyagi M, Kaito T, Yamada K, Banno T, Kato S, Ohba T, Inami S, Fujibayashi S, Katoh H, Kanno H, Oda M, Mori K, Taneichi H, Kawaguchi Y, Takeshita K, Matsumoto M, Yamazaki M, Okawa A, Imagama S. Deep learning-based prediction model for postoperative complications of cervical posterior longitudinal ligament ossification. Eur Spine J. 32(11):3797-3806, 2023

Yunde A, Furuya T, Orita S, Ohtori S, Yokogawa N, Nakashima H, Segi N, Funayama T, Ikegami S, Nakajima H, Watanabe K, Hasegawa T, Tonomura H, Terashima Y, Hashimoto K, Suzuki N, Uei H, Kiyasu K, Tominaga H, Sakai D, Kaito T, Inoue G, Okada S, Imagama S, Kato S. Hangman’s Fracture in Geriatric Population: A Nationwide Multicenter Study in Japan. Global Spine J. 2023 Nov 17:21925682231216925. Online ahead of print

Tezuka F, Sakai T, Imagama S, Takahashi H, Takaso M, Aizawa T, Otani K, Okuda S, Kato S, Kanemura T, Kawaguchi Y, Konishi H, Suda K, Terai H, Nakanishi K, Nishida K, Machino M, Miyakoshi N, Murakami H, Yamato Y, Yukawa Y; Medical Safety Promotion Committee of The Japanese Society for Spine Surgery and Related Research. Management of Antithrombotic Drugs before Elective Spine Surgery: A Nationwide Web-Based Questionnaire Survey in Japan. Spine Surg Relat Res. 7(5):428-435, 2023

Segi N, Nakashima H, Machino M, Ito S, Yokogawa N, Sasagawa T, Funayama T, Eto F, Yamaji A, Watanabe K, Nori S, Takeda K, Furuya T, Yunde A, Nakajima H, Yamada T, Hasegawa T, Terashima Y, Hirota R, Suzuki H, Imajo Y, Ikegami S, Uehara M, Tonomura H, Sakata M, Hashimoto K, Onoda Y, Kawaguchi K, Haruta Y, Suzuki N, Kato K, Uei H, Sawada H, Nakanishi K, Misaki K, Terai H, Tamai K, Shirasawa E, Inoue G, Kakutani K, Kakiuchi Y, Iizuka Y, Takasawa E, Akeda K, Takegami N, Kiyasu K, Tominaga H, Tokumoto H, Funao H, Oshima Y, Yoshii T, Kaito T, Sakai D, Ohba T, Seki S, Otsuki B, Ishihara M, Miyazaki M, Okada S, Imagama S, Kato S. Prognosis of Cervical Diffuse Idiopathic Skeletal Hyperostosis-Related Spine Injuries in Elderly Patients: Analyses of Both Fracture and Spinal Cord Injury Without Fracture. Global Spine J. 2023 Jul 3:21925682231186757. Online ahead of print.

Hirota R, Terashima Y, Ohnishi H, Yamashita T, Yokogawa N, Sasagawa T, Nakashima H, Segi N, Ito S, Funayama T, Eto F, Yamaji A, Watanabe K, Nori S, Takeda K, Furuya T, Yunde A, Nakajima H, Yamada T, Hasegawa T, Suzuki H, Imajo Y, Ikegami S, Uehara M, Tonomura H, Sakata M, Hashimoto K, Onoda Y, Kawaguchi K, Haruta Y, Suzuki N, Kato K, Uei H, Sawada H, Nakanishi K, Misaki K, Terai H, Tamai K, Kuroda A, Inoue G, Kakutani K, Kakiuchi Y, Kiyasu K, Tominaga H, Tokumoto H, Iizuka Y, Takasawa E, Akeda K, Takegami N, Funao H, Oshima Y, Kaito T, Sakai D, Yoshii T, Ohba T, Otsuki B, Seki S, Miyazaki M, Ishihara M, Okada S, Imagama S, Kato S. Prognostic impact of respiratory dysfunction in elderly patients with cervical spinal cord injury and/or fractures: a multicenter survey. Eur Spine J. 32(10):3522-3532, 2023

Segi N, Nakashima H, Ito S, Yokogawa N, Ikegami S, Watanabe K, Funayama T, Hasegawa T, Tonomura H, Kakutani K, Furuya T, Suzuki N, Kiyasu K, Tominaga H, Miyazaki M, Terashima Y, Suzuki H, Hashimoto K, Uei H, Funao H, Kaito T, Kawaguchi K, Sakai D, Seki S, Otsuki B, Inoue G, Okada S, Imagama S, Kato S. Worsening ambulation in elderly patients with cervical odontoid fractures: A nationwide multicenter study in Japan. J Orthop Sci. 2023 Jun 1:S0949-2658(23)00134-3. doi: 10.1016/j.jos.2023.05.006. Online ahead of print.

Tamai K, Terai H, Nakamura H, Yokogawa N, Sasagawa T, Nakashima H, Segi N, Ito S, Funayama T, Eto F, Yamaji A, Watanabe K, Yamane J, Takeda K, Furuya T, Yunde A, Nakajima H, Yamada T, Hasegawa T, Terashima Y, Hirota R, Suzuki H, Imajo Y, Ikegami S, Uehara M, Tonomura H, Sakata M, Hashimoto K, Onoda Y, Kawaguchi K, Haruta Y, Suzuki N, Kato K, Uei H, Sawada H, Nakanishi K, Misaki K, Kuroda A, Inoue G, Kakutani K, Kakiuchi Y, Kiyasu K, Tominaga H, Tokumoto H, Iizuka Y, Takasawa E, Akeda K, Takegami N, Funao H, Oshima Y, Kaito T, Sakai D, Yoshii T, Ohba T, Otsuki B, Seki S, Miyazaki M, Ishihara M, Okada S, Imagama S, Kato S. Delirium Risk Score in Elderly Patients with Cervical Spinal Cord Injury and/or Cervical Fracture. J Clin Med. 12(6):2387, 2023

Okuwaki S, Funayama T, Koda M, Eto F, Yamaji A, Yokogawa N, Sasagawa T, Ando K, Nakashima H, Segi N, Watanabe K, Nori S, Takeda K, Furuya T, Yunde A, Nakajima H, Yamada T, Hasegawa T, Terashima Y, Hirota R, Suzuki H, Imajo Y, Ikegami S, Uehara M, Tonomura H, Sakata M, Hashimoto K, Onoda Y, Kawaguchi K, Haruta Y, Suzuki N, Kato K, Uei H, Sawada H, Nakanishi K, Misaki K, Terai H, Tamai K, Shirasawa E, Inoue G, Kakutani K, Kakiuchi Y, Kiyasu K, Tominaga H, Tokumoto H, Iizuka Y, Takasawa E, Akeda K, Takegami N, Funao H, Oshima Y, Kaito T, Sakai D, Yoshii T, Ohba T, Otsuki B, Seki S, Miyazaki M, Ishihara M, Okada S, Imagama S, Kato S. Characteristics of the cervical spine and cervical cord injuries in older adults with cervical ossification of the posterior longitudinal ligament. Sci Rep. 13(1):2689, 2023

Suzuki H, Funaba M, Imajo Y, Yokogawa N, Sasagawa T, Ando K, Nakashima H, Segi N, Funayama T, Eto F, Watanabe K, Yamane J, Furuya T, Nakajima H, Hasegawa T, Terashima Y, Ikegami S, Inoue G, Kaito T, Kato S. Blunt Cerebrovascular Injury in the Elderly With Traumatic Cervical Spine Injuries: Results of a Retrospective Multi-Center Study of 1512 Cases in Japan. J Neurotrauma. 40(11-12):1164-1172, 2023

Segi N, Nakashima H, Machino M, Ito S, Yokogawa N, Sasagawa T, Funayama T, Eto F, Watanabe K, Nori S, Furuya T, Yunde A, Nakajima H, Hasegawa T, Yamada T, Terashima Y, Hirota R, Suzuki H, Imajo Y, Ikegami S, Uehara M, Tonomura H, Sakata M, Hashimoto K, Onoda Y, Kawaguchi K, Haruta Y, Suzuki N, Kato K, Uei H, Sawada H, Nakanishi K, Misaki K, Terai H, Tamai K, Inoue G, Shirasawa E, Kakutani K, Iizuka Y, Takasawa E, Akeda K, Kiyasu K, Tominaga H, Tokumoto H, Funao H, Oshima Y, Yoshii T, Kaito T, Sakai D, Ohba T, Seki S, Otsuki B, Ishihara M, Miyazaki M, Okada S, Imagama S, Kato S. Epidemiology of Cervical Fracture/Cervical Spinal Cord Injury and Changes in Surgical Treatment Modalities in Elderly Individuals During a 10-year Period: A Nationwide Multicenter Study in Japan. Global Spine J. 2023 Jan 13:21925682231151643. Online ahead of print.

2022年

Demura S, Hinoi E, Kawakami N, Handa M, Yokogawa N, Hiraiwa M, Kato S, Shinmura K, Shimizu T, Oku N, Annen R, Kobayashi M, Yamada Y, Nagatani S, Iezaki T, Taniguchi Y, Tsuchiya H. The L-type Amino Acid Transporter (LAT1) Expression in Patients with Scoliosis. Spine Surg Relat Res. 6(4):402-407, 2022

Demura S, Ohara T, Tauchi R, Takimura K, Watanabe K, Suzuki S, Uno K, Suzuki T, Yanagida H, Yamaguchi T, Kotani T, Nakayama K, Watanabe K, Yokogawa N, Oku N, Tsuchiya H, Yamamoto T, Kawamura I, Taniguchi Y, Takeshita K, Sugawara R, Kikkawa I, Sato T, Fujiwara K, Akazawa T, Murakami H, Kawakami N; Japan Spinal Deformity Institute. Incidence and causes of instrument-related complications after primary definitive fusion for pediatric spine deformity. J Neurosurg Spine. 38(2):192-198, 2022.

Kato S, Demura S, Murakami H, Shinmura K, Yokogawa N, Annen R, Kobayashi M, Yamada Y, Nagatani S, Kawahara N, Tsuchiya H. Medium to Long-Term Clinical Outcomes of Spinal Metastasectomy. Cancers (Basel). 14(12):2852, 2022

Kato S, Demura S, Shinmura K, Yokogawa N, Kurokawa Y, Annen R, Kobatashi M, Yamada Y, Nagatani S, Matsubara H, Kabata T, Tsuchiya H. Associations between Abdominal Trunk Muscle Weakness and Future Osteoporotic Vertebral Fracture in Middle-Aged and Older Adult Women: A Three-Year Prospective Longitudinal Cohort Study. J Clin Med. 11(16):4868, 2022

Kato S, Demura S, Kabata T, Matsubara H, Kurokawa Y, Kajino Y, Okamoto Y, Kuroda K, Kimura H, Shinmura K, Yokogawa N, Shimizu T, Igarashi K, Inoue D, Tsuchiya H. Evaluation of locomotive syndrome in patients receiving surgical treatment for degenerative musculoskeletal diseases: A multicentre prospective study using the new criteria. Mod Rheumatol. 32(4):822-829, 2022

Sasagawa T, Yokogawa N, Hayashi H, Tsuchiya H, Ando K, Nakashima H, Segi N, Watanabe K, Nori S, Takeda K, Furuya T, Yunde A, Ikegami S, Uehara M, Suzuki H, Imajo Y, Funayama T, Eto F, Yamaji A, Hashimoto K, Onoda Y, Kakutani K, Kakiuchi Y, Suzuki N, Kato K, Terashima Y, Hirota R, Yamada T, Hasegawa T, Kawaguchi K, Haruta Y, Seki S, Tonomura H, Sakata M, Uei H, Sawada H, Tominaga H, Tokumoto H, Kaito T, Iizuka Y, Takasawa E, Oshima Y, Terai H, Tamai K, Otsuki B, Miyazaki M, Nakajima H, Nakanishi K, Misaki K, Inoue G, Kiyasu K, Akeda K, Takegami N, Yoshii T, Ishihara M, Okada S, Aoki Y, Harimaya K, Murakami H, Ishii K, Ohtori S, Imagama S, Kato S. A multicenter study of 1-year mortality and walking capacity after spinal fusion surgery for cervical fracture in elderly patients. BMC Musculoskelet Disord. 20;23(1):798, 2022

Shinmura K, Demura S, Kato S, Yokogawa N, Handa M, Annen R, Kobayashi M, Yamada Y, Nagatani S, Murakami H, Tsuchiya H. A Modified Spinal Reconstruction Method Reduces Instrumentation Failure in Total En Bloc Spondylectomy for Spinal Tumors. Spine Surg Relat Res. 7(1):60-65, 2022

Yokogawa N, Kato S, Sasagawa T, Hayashi H, Tsuchiya H, Ando K, Nakashima H, Segi N, Funayama T, Eto F, Yamaji A, Nori S, Yamane J, Furuya T, Yunde A, Nakajima H, Yamada T, Hasegawa T, Terashima Y, Hirota R, Suzuki H, Imajo Y, Ikegami S, Uehara M, Tonomura H, Sakata M, Hashimoto K, Onoda Y, Kawaguchi K, Haruta Y, Suzuki N, Kato K, Uei H, Sawada H, Nakanishi K, Misaki K, Terai H, Tamai K, Shirasawa E, Inoue G, Kakutani K, Kakiuchi Y, Kiyasu K, Tominaga H, Tokumoto H, Iizuka Y, Takasawa E, Akeda K, Takegami N, Funao H, Oshima Y, Kaito T, Sakai D, Yoshii T, Ohba T, Otsuki B, Seki S, Miyazaki M, Ishihara M, Okada S, Imagama S, Watanabe K. Differences in clinical characteristics of cervical spine injuries in older adults by external causes: a multicenter study of 1512 cases. Sci Rep. 12(1):15867, 2022

Yonezawa Y, Yonezawa N, Kanazawa Y, Yonezawa T, Yonezawa K, Demura S. Revision balloon kyphoplasty and vertebra-pediculoplasty using cannulated screws for osteoporotic vertebral fractures with cement dislodgement following conventional balloon kyphoplasty. J Neurointerv Surg. 14(8):844-846, 2022

Kurokawa Y, Kato S, Demura S, Shinmura K, Yokogawa N, Yonezawa N, Shimizu T, Kitagawa R, Miaki H, Tsuchiya H. Validation and comparison of trunk muscle activities in male participants during exercise using an innovative device and abdominal bracing maneuvers. J Back Musculoskelet Rehabil. 35(3):589-596, 2022

Annen R, Kato S, Demura S, Miwa S, Yokka A, Shinmura K, Yokogawa N, Yonezawa N, Kobayashi M, Kurokawa Y, Gabata T, Tsuchiya H. Tumor-Specific Immunoenhancing Effects after Local Cryoablation for Metastatic Bone Tumor in a Mouse Model. Int J Mol Sci. 23(16):9445, 2022

Kobayashi M, Demura S, Kato S, Yoshioka K, Shinmura K, Yokogawa N, Yonezawa N, Handa M, Annen R, Yamada Y, Nagatani S, Tsuchiya H. Prevalence and Risk Factors for the Development of Venous Thromboembolism After Spinal Tumor Surgery. World Neurosurg. 164:e177-e182, 2022

Yamada Y, Demura S, Kato S, Shinmura K, Yokogawa N, Handa M, Annen R, Kobayashi M, Nagatani S, Tsuchiya H. Anatomical Characteristics and Variations of Thoracic Segmental Arteries with 3-dimensional CT Analysis. Spine (Phila Pa 1976). 47(22):E617-E624, 2022

Yamada Y, Toribatake Y, Okamoto S, Kato S, Kobayashi M, Tsuchiya H. Recompression of Augmented Vertebrae after Balloon Kyphoplasty Is a Risk of Adjacent Vertebral Fracture. Spine Surg Relat Res. 7(1):89-95, 2022

Nagatani S, Demura S, Kato S, Kabata T, Kajino Y, Yokogawa N, Inoue D, Kurokawa Y, Kobayashi M, Yamada Y, Kawai M, Tsuchiya H. Risk Factors for Progressive Spinal Sagittal Imbalance in the Short-Term Course after Total Hip Arthroplasty: A 3 Year Follow-Up Study of Female Patients. J Clin Med. 11(17):5179, 2022

Ishino Y, Shinmura K, Kato S, Yokogawa N, Kawahara N, Demura S, Tsuchiya H. Major complications after total en bloc spondylectomy with high-dose radiation therapy for spinal metastasis: A case report and review of literature. Interdiscip Neurosurg. 25: 101279, 2022

Rakhmat A, Demura S, Kato S, Shinmura K, Yokogawa N, Yonezawa N, Kitagawa R, Yoshizaki T, Kawahara N, Tsuchiya H. Challenges in surgery of recurrent giant cell tumor of the cervical spine: A case report and review of the literature. JOS Case reports. 2022 accepted.

Ueoka K, Kabata T, Kajino Y, Inoue D, Ohmori T, Ueno T, Yoshitani J, Yamamuro Y, Taninaka A, Kato S, Yahata T, Tsuchiya H. The prevalence and impact of sarcopenia in females undergoing total hip arthroplasty: A prospective study. Mod Rheumatol. 32(1):193-198, 2022

Asano Y, Yamamoto N, Demura S, Hayashi K, Takeuchi A, Kato S, Miwa S, Igarashi K, Higuchi T, Yonezawa H, Araki Y, Morinaga S, Saito S, Sone T, Kasahara K, Tsuchiya H. The Therapeutic Effect and Clinical Outcome of Immune Checkpoint Inhibitors on Bone Metastasis in Advanced Non-Small-Cell Lung Cancer. Front Oncol. 12:871675, 2022

Hamada T, Matsubara H, Kato S, Hikichi T, Shimokawa K, Demura S, Tsuchiya H. Correlation Analysis between Leg-length Discrepancy and Lumbar Scoliosis Using Full-length Standing Radiographs. Strategies Trauma Limb Reconstr. 17(3):144-147, 2022

Iwahashi S, Lyu J, Tokumura K, Osumi R, Hiraiwa M, Kubo T, Horie T, Demura S, Kawakami N, Saito T, Park G, Fukasawa K, Iezaki T, Suzuki A, Tomizawa A, Ochi H, Hojo H, Ohba S, Hinoi E. Conditional inactivation of the L-type amino acid transporter LAT1 in chondrocytes models idiopathic scoliosis in mice.　J Cell Physiol. 237(11):4292-4302, 2022

Sato T, Yonezawa I, Matsumoto H, Otomo N, Suzuki T, Manabe N, Demura S, Watanabe K, Saito T, Nohara A, Kurakawa T, Shimizu T, Uno K, Matsumoto M, Kawakami N. Surgical Predictors for Prevention of Postoperative Shoulder Imbalance in Lenke Type 2A Adolescent Idiopathic Scoliosis. Spine (Phila Pa 1976). 47(4):E132-E141, 2022

Yoshii T, Morishita S, Egawa S, Sakai K, Kusano K, Tsutsui S, Hirai T, Matsukura Y, Wada K, Katsumi K, Koda M, Kimura A, Furuya T, Maki S, Nagoshi N, Nishida N, Nagamoto Y, Oshima Y, Ando K, Nakashima H, Takahata M, Mori K, Nakajima H, Murata K, Miyagi M, Kaito T, Yamada K, Banno T, Kato S, Ohba T, Inami S, Fujibayashi S, Katoh H, Kanno H, Taneichi H, Imagama S, Kawaguchi Y, Takeshita K, Matsumoto M, Yamazaki M, Okawa A. Prospective Investigation of Surgical Outcomes after Anterior Decompression with Fusion and Laminoplasty for the Cervical Ossification of the Posterior Longitudinal Ligament: A Propensity Score Matching Analysis. J Clin Med. 11(23):7012, 2022

Nagoshi N, Yoshii T, Egawa S, Sakai K, Kusano K, Tsutsui S, Hirai T, Matsukura Y, Wada K, Katsumi K, Koda M, Kimura A, Furuya T, Maki S, Nishida N, Nagamoto Y, Oshima Y, Ando K, Nakashima H, Takahata M, Mori K, Nakajima H, Murata K, Miyagi M, Kaito T, Yamada K, Banno T, Kato S, Ohba T, Inami S, Fujibayashi S, Katoh H, Kanno H, Watanabe K, Taneichi H, Imagama S, Kawaguchi Y, Takeshita K, Nakamura M, Matsumoto M, Yamazaki M, Okawa A. Clinical Indicators of Surgical Outcomes After Laminoplasty for Patients With Cervical Ossification of the Posterior Longitudinal Ligament: A Prospective Multicenter Study. Spine (Phila Pa 1976). 47(15):1077-1083, 2022

Hirai T, Yoshii T, Hashimoto J, Ushio S, Mori K, Maki S, Katsumi K, Nagoshi N, Takeuchi K, Furuya T, Watanabe K, Nishida N, Nishimura S, Watanabe K, Kaito T, Kato S, Nagashima K, Koda M, Nakashima H, Imagama S, Murata K, Matsuoka Y, Wada K, Kimura A, Ohba T, Katoh H, Watanabe M, Matsuyama Y, Ozawa H, Haro H, Takeshita K, Matsumoto M, Nakamura M, Egawa S, Matsukura Y, Inose H, Okawa A, Yamazaki M, Kawaguchi Y. Clinical Characteristics of Patients with Ossification of the Posterior Longitudinal Ligament and a High OP Index: A Multicenter Cross-Sectional Study (JOSL Study). J Clin Med. 11(13):3694, 2022

Mori K, Yoshii T, Egawa S, Sakai K, Kusano K, Tsutsui S, Hirai T, Matsukura Y, Wada K, Katsumi K, Koda M, Kimura A, Furuya T, Maki S, Nagoshi N, Nishida N, Nagamoto Y, Oshima Y, Ando K, Nakashima H, Takahata M, Nakajima H, Murata K, Miyagi M, Kaito T, Yamada K, Banno T, Kato S, Ohba T, Inami S, Fujibayashi S, Katoh H, Kanno H, Taneichi H, Imagama S, Kawaguchi Y, Takeshita K, Matsumoto M, Yamazaki M, Okawa A. Impact of obesity on cervical ossification of the posterior longitudinal ligament: a nationwide prospective study. Sci Rep. 12(1):8884, 2022

Inoue T, Maki S, Yoshii T, Furuya T, Egawa S, Sakai K, Kusano K, Nakagawa Y, Hirai T, Wada K, Katsumi K, Fujii K, Kimura A, Nagoshi N, Kanchiku T, Nagamoto Y, Oshima Y, Ando K, Takahata M, Mori K, Nakajima H, Murata K, Matsunaga S, Kaito T, Yamada K, Kobayashi S, Kato S, Ohba T, Inami S, Fujibayashi S, Katoh H, Kanno H, Imagama S, Koda M, Kawaguchi Y, Takeshita K, Matsumoto M, Ohtori S, Yamazaki M, Okawa A. Is anterior decompression and fusion more beneficial than laminoplasty for K-line (+) cervical ossification of the posterior longitudinal ligament? An analysis using propensity score matching. J Neurosurg Spine. 2022 Jan 14;1-8. doi: 10.3171/2021.11.SPINE211205. Online ahead of print.

Nakashima H, Imagama S, Yoshii T, Egawa S, Sakai K, Kusano K, Nakagawa Y, Hirai T, Wada K, Katsumi K, Fujii K, Kimura A, Furuya T, Kanchiku T, Nagamoto Y, Oshima Y, Nagoshi N, Ando K, Takahata M, Mori K, Nakajima H, Murata K, Matsunaga S, Kaito T, Yamada K, Kobayashi S, Kato S, Ohba T, Inami S, Fujibayashi S, Katoh H, Kanno H, Li Y, Yatsuya H, Koda M, Kawaguchi Y, Takeshita K, Matsumoto M, Yamazaki M, Okawa A; Japanese Multicenter Research Organization for Ossification of the Spinal Ligament. Comparison of laminoplasty and posterior fusion surgery for cervical ossification of posterior longitudinal ligament. Sci Rep. 12(1):748, 2022

Mori K, Yoshii T, Hirai T, Maki S, Katsumi K, Nagoshi N, Nishimura S, Takeuchi K, Ushio S, Furuya T, Watanabe K, Nishida N, Watanabe K, Kaito T, Kato S, Nagashima K, Koda M, Ito K, Imagama S, Matsuoka Y, Wada K, Kimura A, Ohba T, Katoh H, Matsuyama Y, Ozawa H, Haro H, Takeshita K, Watanabe M, Matsumoto M, Nakamura M, Yamazaki M, Okawa A, Kawaguchi Y. The characteristics of the young patients with cervical ossification of the posterior longitudinal ligament of the spine: A multicenter cross-sectional study. J Orthop Sci. 27(4):760-766, 2022

Hirai T, Yoshii T, Egawa S, Sakai K, Kusano K, Nakagawa Y, Wada K, Katsumi K, Fujii K, Kimura A, Furuya T, Nagoshi N, Kanchiku T, Nagamoto Y, Oshima Y, Ando K, Takahata M, Mori K, Nakajima H, Murata K, Matsunaga S, Kaito T, Yamada K, Kobayashi S, Kato S, Ohba T, Inami S, Fujibayashi S, Katoh H, Kanno H, Imagama S, Koda M, Kawaguchi Y, Takeshita K, Matsumoto M, Yamazaki M, Okawa A. Severity of Myelopathy is Closely Associated With Advanced Age and Signal Intensity Change in Cervical Ossification of the Posterior Longitudinal Ligament: A Prospective Nationwide Investigation. Clin Spine Surg. 35(1):E155-E161, 2022

Endo T, Imagama S, Kato S, Kaito T, Sakai H, Ikegawa S, Kawaguchi Y, Kanayama M, Hisada Y, Koike Y, Ando K, Kobayashi K, Oda I, Okada K, Takagi R, Iwasaki N, Takahata M. Association Between Vitamin A Intake and Disease Severity in Early-Onset Heterotopic Ossification of the Posterior Longitudinal Ligament of the Spine. Global Spine J. 12(8):1770-1780, 2022

Inoue G, Miyagi M, Saito W, Shirasawa E, Uchida K, Hosogane N, Watanabe K, Katsumi K, Kaito T, Yamashita T, Fujiwara H, Nagamoto Y, Nojiri K, Suzuki S, Okada E, Ueda S, Hikata T, Shiono Y, Watanabe K, Terai H, Tamai K, Matsuoka Y, Suzuki H, Nishimura H, Tagami A, Yamada S, Adachi S, Ohtori S, Furuya T, Orita S, Inage K, Yoshii T, Ushio S, Funao H, Isogai N, Harimaya K, Kawaguchi K, Okada S, Yokoyama N, Oishi H, Doi T, Kiyasu K, Imagama S, Ando K, Kobayashi K, Sakai D, Tanaka M, Kimura A, Inoue H, Nakano A, Ikegami S, Shimizu M, Futatsugi T, Kakutani K, Yurube T, Nakanishi K, Oshima M, Uei H, Aoki Y, Takahata M, Iwata A, Endo H, Seki S, Murakami H, Kato S, Yoshioka K, Hongo M, Abe T, Tsukanishi T, Tasaso M, Ishii K. Effect of Low Body Mass Index on Clinical Recovery After Fusion Surgery for Osteoporotic Vertebral Fracture: A Retrospective, Multicenter Study of 237 Cases. Medicine. 101(52):e32330, 2022

Uehara M, Ikegami S, Takizawa T, Oba H, Yokogawa N, Sasagawa T, Ando K, Nakashima H, Segi N, Funayama T, Eto F, Yamaji A, Watanabe K, Nori S, Takeda K, Furuya T, Yunde A, Nakajima H, Yamada T, Hasegawa T, Terashima Y, Hirota R, Suzuki H, Imajo Y, Tonomura H, Sakata M, Hashimoto K, Onoda Y, Kawaguchi K, Haruta Y, Suzuki N, Kato K, Uei H, Sawada H, Nakanishi K, Misaki K, Terai H, Tamai K, Shirasawa E, Inoue G, Kakutani K, Kakiuchi Y, Kiyasu K, Tominaga H, Tokumoto H, Iizuka Y, Takasawa E, Akeda K, Takegami N, Funao H, Oshima Y, Kaito T, Sakai D, Yoshii T, Otsuki B, Seki S, Miyazaki M, Ishihara M, Okada S, Imagama S, Kato S. Factors affecting the waiting time from injury to surgery in elderly patients with cervical spine injury: A Japanese multicenter survey. World Neurosurg. 166:e815-e822, 2022

Nori S, Watanabe K, Takeda K, Yamane J, Kono H, Yokogawa N, Sasagawa T, Ando K, Nakashima H, Segi N, Funayama T, Eto F, Yamaji A, Furuya T, Yunde A, Nakajima H, Yamada T, Hasegawa T, Terashima Y, Hirota R, Suzuki H, Imajo Y, Ikegami S, Uehara M, Tonomura H, Sakata M, Hashimoto K, Onoda Y, Kawaguchi K, Haruta Y, Suzuki N, Kato K, Uei H, Sawada H, Nakanishi K, Misaki K, Terai H, Tamai K, Shirasawa E, Inoue G, Kiyasu K, Iizuka Y, Takasawa E, Funao H, Kaito T, Yoshii T, Ishihara M, Okada S, Imagama S, Kato S. Does surgery improve neurological outcomes in older individuals with cervical spinal cord injury without bone injury? A multicenter study. Spinal Cord. 60(10):895-902, 2022

Nagajima H, Yokogawa N, Sasagawa T, Ando K, Nakashima H, Watanabe K, Nori S, Watanabe S, Honjoh K, Funayama T, Eto F, Terashima Y, Hirota R, Furuya T, Hasegawa T, Inoue G, Kaito T, Kato S. Prognostic factors for cervical spinal cord injury without major bone injury in elderly patients. J Neurotrauma. 39(9-10):658-666, 2022

Uehara M, Ikegami S, Takizawa T, Oba H, Yokogawa N, Sasagawa T, Ando K, Nakashima H, Segi N, Funayama T, Eto F, Yamaji A, Watanabe K, Nori S, Takeda K, Furuya T, Yunde A, Nakajima H, Yamada T, Hasegawa T, Terashima Y, Hirota R, Suzuki H, Imajo Y, Tonomura H, Sakata M, Hashimoto K, Onoda Y, Kawaguchi K, Haruta Y, Suzuki N, Kato K, Uei H, Sawada H, Nakanishi K, Misaki K, Terai H, Tamai K, Shirasawa E, Inoue G, Kakutani K, Kakiuchi Y, Kiyasu K, Tominaga H, Tokumoto H, Iizuka Y, Takasawa E, Akeda K, Takegami N, Funao H, Oshima Y, Kaito T, Sakai D, Yoshii T, Otsuki B, Seki S, Miyazaki M, Ishihara M, Okada S, Aoki Y, Harimaya K, Murakami H, Ishii K, Ohtori S, Imagama S, Kato S. Is blood loss greater in elderly patients under antiplatelet or anticoagulant medication for cervical spine injury surgery: A Japanese multicenter survey. Spine Surg Relat Res. 6(4):366-372, 2022

2021年

Demura S, Kato S, Shinmura K, Yokogawa N, Shimizu T, Handa M, Annen R, Kobayashi M, Yamada Y, Murakami H, Kawahara N, Tomita K, Tsuchiya H.
Perioperative complications of total en bloc spondylectomy for spinal tumours.
Bone Joint J. 2021 May;103-B(5):976-983.

Kato S, Demura S, Shinmura K, Yokogawa N, Shimizu T, Murakami H, Kawahara N, Tomita K, Tsuchiya H.
Surgical Metastasectomy in the Spine: A Review Article.
Oncologist. 2021 Oct;26(10):e1833-e1843.

Kato S, Demura S, Tsuchiya H.
In Reply.　Oncologist. 2021 Nov;26(11):e2098.

Kato S, Demura S, Shinmura K, Yokogawa N, Shimizu T, Tsuchiya H.
Current Management of Bone Metastases from Differentiated Thyroid Cancer.
Cancers (Basel). 2021 Sep 2;13(17):4429.

Kato S, Demura S, Murakami H, Yoshioka K, Shinmura K, Yokogawa N, Shimizu T, Kawahara N, Tsuchiya H.
Clinical outcomes and prognostic factors following the surgical resection of renal cell carcinoma spinal metastases.
Cancer Sci. 2021 Jun;112(6):2416-2425. doi: 10.1111/cas.14902. Epub 2021 May 1.

Kato S, Demura S, Shinmura K, Yokogawa N, Kabata T, Matsubara H, Kajino Y, Igarashi K, Inoue D, Kurokawa Y, Oku N, Tsuchiya H.
Association of low back pain with muscle weakness, decreased mobility function, and malnutrition in older women: A cross-sectional study.
PLoS One. 2021 Jan 25;16(1):e0245879.

Igarashi T, Demura S, Kato S, Shinmura K, Yokogawa N, Yonezawa N, Shimizu T, Oku N, Murakami H, Tsuchiya H.
Effects of Radiation on the Bone Strength of Spinal Vertebrae in Rats.
Spine (Phila Pa 1976). 2021 Nov 19. doi: 10.1097/BRS.0000000000004282. Online ahead of print. PMID: 34802029

Yonezawa N, Murakami H, Demura S, Kato S, Miwa S, Yoshioka K, Shinmura K, Yokogawa N, Shimizu T, Oku N, Kitagawa R, Handa M, Annen R, Kurokawa Y, Fushimi K, Mizukoshi E, Tsuchiya H.
Abscopal Effect of Frozen Autograft Reconstruction Combined with an Immune Checkpoint Inhibitor Analyzed Using a Metastatic Bone Tumor Model.
Int J Mol Sci. 2021 Feb 17;22(4):1973.

Shimizu T, Demura S, Kato S, Shinmura K, Yokogawa N, Yonezawa N, Oku N, Kitagawa R, Handa M, Annen R, Nojima T, Murakami H, Tsuchiya H.
Radiation Disrupts the Protective Function of the Spinal Meninges in a Mouse Model of Tumor-induced Spinal Cord Compression.
Clin Orthop Relat Res. 2021 Jan 1;479(1):163-176.

Shimizu T, Kato S, Demura S, Shinmura K, Yokogawa N, Kurokawa Y, Yonezawa N, Oku N, Kitagawa R, Handa M, Annen R, Okamoto Y, Murakami H, Tsuchiya H.
The efficacy of surgical treatment on locomotive syndrome and physical function in patients with lumbar spinal canal stenosis.
J Orthop Sci. 2021 May;26(3):327-331.

Kurokawa Y, Kato S, Demura S, Shinmura K, Yokogawa N, Yonezawa N, Shimizu T, Kitagawa R, Miaki H, Tsuchiya H.
Validation and comparison of trunk muscle activities in male participants during exercise using an innovative device and abdominal bracing maneuvers.
J Back Musculoskelet Rehabil. 2021 Aug 3. doi: 10.3233/BMR-210001. Online ahead of print. PMID: 34397401

Kitagawa R, Kato S, Demura S, Kurokawa Y, Shinmura K, Yokogawa N, Yonezawa N, Shimizu T, Oku N, Handa M, Annen R, Tsuchiya H.
Efficacy of abdominal trunk muscles-strengthening exercise using an innovative device in treating chronic low back pain: a controlled clinical trial.
Sci Rep. 2020 Dec 14;10(1):21883.

Ng YH, Kato S, Demura S, Shinmura K, Yokogawa N, Nakade Y, Yonezawa N, Shimizu T, Tsuchiya H.
Delayed ischemic spinal cord injury after total en bloc spondylectomy in the thoracic spine.
J Orthop Sci. 2021 Jan 8:S0949-2658(20)30373-0.

Yonezawa N, Yonezawa Y, Nishimura T, Yamashiro T, Shimozaki K, Sakaue A, Demura S, Tsuchiya H.
Vertebra-pediculoplasty: a new approach to treatment of split type and delayed union osteoporotic vertebral fracture with a risk of cement dislodgment.
World Neurosurg. 2021 Aug 5:S1878-8750(21)01161-X.

Kobayashi M, Ohya J, Onitsha Y, Kunogi J, Kawamura N.
Medialization of Common Carotid Artery Is Associated with Cervical Kyphosis.
Spine Surg Relat Res. 2020 Nov 20;5(3):144-148.

Otomo N, Lu HF, Koido M, Kou I, Takeda K, Momozawa Y, Kubo M, Kamatani Y, Ogura Y, Takahashi Y, Nakajima M, Minami S, Uno K, Kawakami N, Ito M, Sato T, Watanabe K, Kaito T, Yanagida H, Taneichi H, Harimaya K, Taniguchi Y, Shigematsu H, Iida T, Demura S, Sugawara R, Fujita N, Yagi M, Okada E, Hosogane N, Kono K, Nakamura M, Chiba K, Kotani T, Sakuma T, Akazawa T, Suzuki T, Nishida K, Kakutani K, Tsuji T, Sudo H, Iwata A, Kaneko K, Inami S, Kochi Y, Chang WC, Matsumoto M, Watanabe K, Ikegawa S, Terao C.
Polygenic Risk Score of Adolescent Idiopathic Scoliosis for Potential Clinical Use.
J Bone Miner Res. 2021 Aug;36(8):1481-1491.

Sato T, Yonezawa I, Matsumoto H, Otomo N, Suzuki T, Manabe N, Demura S, Watanabe K, Saito T, Nohara A, Kurakawa T, Shimizu T, Uno K, Matsumoto M, Kawakami N.
Surgical Predictors for Prevention of Postoperative Shoulder Imbalance in Lenke Type 2A Adolescent Idiopathic Scoliosis.
Spine (Phila Pa 1976). 2022 Feb 15;47(4):E132-E141.

Watanabe K, Yamaguchi T, Suzuki S, Suzuki T, Nakayama K, Demura S, Taniguchi Y, Yamamoto T, Sugawara R, Sato T, Fujiwara K, Murakami H, Akazawa T, Kakutani K, Hirano T, Yanagida H, Watanabe K, Matsumoto M, Uno K, Kotani T, Takeshita K, Ohara T, Kawakami N; Japan Spinal Deformity Institute Study Group.
Surgical Site Infection following Primary Definitive Fusion for Pediatric Spinal Deformity: A Multicenter Study of Rates, Risk Factors, and Pathogens.
Spine (Phila Pa 1976). 2021 Aug 15;46(16):1097-1104.

Taniguchi Y, Ohara T, Suzuki S, Watanabe K, Suzuki T, Uno K, Yamaguchi T, Yanagida H, Nakayama K, Kotani T, Watanabe K, Hirano T, Yamamoto T, Kawamura I, Sugawara R, Takeshita K, Demura S, Oku N, Sato T, Fujiwara K, Akazawa T, Murakami H, Kakutani K, Matsubayashi Y, Kawakami N.
Incidence and Risk Factors for Unplanned Return to the Operating Room Following Primary Definitive Fusion for Pediatric Spinal Deformity: A Multicenter Study with Minimum 2-year Follow-Up.
Spine (Phila Pa 1976). 2021 Apr 15;46(8):E498-E504.

Hikata T, Ishii K, Matsumoto M, Kobayashi K, Imagama S, Ando K, Ishiguro N, Yamashita M, Seki S, Terai H, Suzuki A, Tamai K, Aramomi M, Ishikawa T, Kimura A, Inoue H, Inoue G, Miyagi M, Saito W, Yamada K, Hongo M, Endo K, Suzuki H, Nakano A, Watanabe K, Ohya J, Chikuda H, Aoki Y, Shimizu M, Futatsugi T, Mukaiyama K, Hasegawa M, Kiyasu K, Iizuka H, Kobayashi R, Iizuka Y, Nishida K, Kakutani K, Nakajima H, Murakami H, Demura S, Kato S, Yoshioka K, Namikawa T, Watanabe K, Nakanishi K, Nakagawa Y, Yoshimoto M, Fujiwara H, Nishida N, Imajo Y, Yamazaki M, Abe T, Fujii K, Kaito T, Eguchi Y, Furuya T, Orita S, Ohtori S.
Risk Factor for Poor Patient Satisfaction After Lumbar Spine Surgery in Elderly Patients Aged Over 80 years.
Clin Spine Surg. 2021 May 1;34(4):E223-E228.

Katsumi K, Hirai T, Yoshii T, Maki S, Mori K, Nagoshi N, Nishimura S, Takeuchi K, Ushio S, Furuya T, Watanabe K, Nishida N, Watanabe K, Kaito T, Kato S, Nagashima K, Koda M, Ito K, Imagama S, Matsuoka Y, Wada K, Kimura A, Ohba T, Katoh H, Matsuyama Y, Ozawa H, Haro H, Takeshita K, Watanabe M, Matsumoto M, Nakamura M, Yamazaki M, Okawa A, Kawaguchi Y.
The impact of ossification spread on cervical spine function in patients with ossification of the posterior longitudinal ligament. Sci Rep. 2021 Jul 12;11(1):14337.

Koda M, Yoshii T, Egawa S, Sakai K, Kusano K, Nakagawa Y, Hirai T, Wada K, Katsumi K, Kimura A, Furuya T, Maki S, Nagoshi N, Watanabe K, Kanchiku T, Nagamoto Y, Oshima Y, Ando K, Nakashima H, Takahata M, Mori K, Nakajima H, Murata K, Matsunaga S, Kaito T, Yamada K, Kobayashi S, Kato S, Ohba T, Inami S, Fujibayashi S, Katoh H, Kanno H, Takahashi H, Fujii K, Miyagi M, Inoue G, Takaso M, Imagama S, Kawaguchi Y, Takeshita K, Nakamura M, Matsumoto M, Okawa A, Yamazaki M.
Neurological improvement is associated with neck pain attenuation after surgery for cervical ossification of the posterior longitudinal ligament.
Sci Rep. 2021 Jun 7;11(1):11910.

Mori K, Yoshii T, Hirai T, Maki S, Katsumi K, Nagoshi N, Nishimura S, Takeuchi K, Ushio S, Furuya T, Watanabe K, Nishida N, Watanabe K, Kaito T, Kato S, Nagashima K, Koda M, Ito K, Imagama S, Matsuoka Y, Wada K, Kimura A, Ohba T, Katoh H, Matsuyama Y, Ozawa H, Haro H, Takeshita K, Watanabe M, Matsumoto M, Nakamura M, Yamazaki M, Okawa A, Kawaguchi Y.
The characteristics of the young patients with cervical ossification of the posterior longitudinal ligament of the spine: A multicenter cross-sectional study.
J Orthop Sci. 2021 Jun 3:S0949-2658(21)00147-0.

Maki S, Furuya T, Yoshii T, Egawa S, Sakai K, Kusano K, Nakagawa Y, Hirai T, Wada K, Katsumi K, Fujii K, Kimura A, Nagoshi N, Kanchiku T, Nagamoto Y, Oshima Y, Ando K, Takahata M, Mori K, Nakajima H, Murata K, Matsunaga S, Kaito T, Yamada K, Kobayashi S, Kato S, Ohba T, Inami S, Fujibayashi S, Katoh H, Kanno H, Imagama S, Koda M, Kawaguchi Y, Takeshita K, Matsumoto M, Ohtori S, Yamazaki M, Okawa A.
Machine Learning Approach in Predicting Clinically Significant Improvements After Surgery in Patients with Cervical Ossification of the Posterior Longitudinal Ligament.
Spine (Phila Pa 1976). 2021 Dec 15;46(24):1683-1689.

Nagoshi N, Yoshii T, Egawa S, Sakai K, Kusano K, Nakagawa Y, Hirai T, Wada K, Katsumi K, Fujii K, Kimura A, Furuya T, Kanchiku T, Nagamoto Y, Oshima Y, Nakashima H, Ando K, Takahata M, Mori K, Nakajima H, Murata K, Matsunaga S, Kaito T, Yamada K, Kobayashi S, Kato S, Ohba T, Inami S, Fujibayashi S, Katoh H, Kanno H, Watanabe K, Imagama S, Koda M, Kawaguchi Y, Takeshita K, Nakamura M, Matsumoto M, Yamazaki M, Okawa A.
Comparison of Surgical Outcomes After Open- and Double-Door Laminoplasties for Patients with Cervical Ossification of the Posterior Longitudinal Ligament: A Prospective Multicenter Study.
Spine (Phila Pa 1976). 2021 Dec 1;46(23):E1238-E1245.

Hirai T, Yoshii T, Egawa S, Sakai K, Kusano K, Nakagawa Y, Wada K, Katsumi K, Fujii K, Kimura A, Furuya T, Nagoshi N, Kanchiku T, Nagamoto Y, Oshima Y, Ando K, Takahata M, Mori K, Nakajima H, Murata K, Matsunaga S, Kaito T, Yamada K, Kobayashi S, Kato S, Ohba T, Inami S, Fujibayashi S, Katoh H, Kanno H, Imagama S, Koda M, Kawaguchi Y, Takeshita K, Matsumoto M, Yamazaki M, Okawa A.
Severity of Myelopathy is Closely Associated With Advanced Age and Signal Intensity Change in Cervical Ossification of the Posterior Longitudinal Ligament: A Prospective Nationwide Investigation.
Clin Spine Surg. 2022 Feb 1;35(1):E155-E161.

Endo T, Imagama S, Kato S, Kaito T, Sakai H, Ikegawa S, Kawaguchi Y, Kanayama M, Hisada Y, Koike Y, Ando K, Kobayashi K, Oda I, Okada K, Takagi R, Iwasaki N, Takahata M.
Association Between Vitamin A Intake and Disease Severity in Early-Onset Heterotopic Ossification of the Posterior Longitudinal Ligament of the Spine.
Global Spine J. 2021 Jan 25:2192568221989300.

2020年

Demura S, Kato S, Shinmura K, Yokogawa N, Yonezawa N, Shimizu T, Oku N, Kitagawa R, Handa M, Annen R, Murakami H, Kawahara N, Tsuchiya H.
More Than 10-year Follow-up After Laminoplasty and Pedicle Screw Fixation for Cervical Myelopathy Associated With Athetoid Cerebral Palsy.
Spine (Phila Pa 1976). 2020 Jun 1;45(11):727-734.

Demura S, Watanabe K, Suzuki T, Saito T, Yamamoto T, Kotani T, Nohara A, Tsuji T, Ogura Y, Tsuchiya H, Uno K, Matsumoto M, Kawakami N.
Japan Spinal Deformity Institute. Comparison of Pulmonary Function After Selective Anterior Versus Posterior Fusion for the Correction of Thoracolumbar and Lumbar Adolescent Idiopathic Scoliosis.
Global Spine J. 2020 Jun;10(4):433-437.

Kato S, Demura S, Murakami H, Tsuchiya H.
Surgical metastasectomy for renal cell carcinoma: which patients are the real candidates for surgery?
Ann Transl Med. 2019 Dec;7(Suppl 8):S273.

Kato S, Demura S, Shinmura K, Yokogawa N, Yonezawa N, Shimizu T, Oku N, Kitagawa R, Murakami H, Kawahara N, Tomita K, Tsuchiya H.
Clinical outcomes and survivals after total en bloc spondylectomy for metastatic leiomyosarcoma in the spine.
Eur Spine J. 2020 Dec;29(12):3237-3244.

Kato S, Kurokawa Y, Kabata T, Demura S, Matsubara H, Kajino Y, Okamoto Y, Kimura H, Shinmura K, Igarashi K, Shimizu T, Yonezawa N, Yokogawa N, Tsuchiya H.
Improvement of locomotive syndrome with surgical treatment in patients with degenerative diseases in the lumbar spine and lower extremities: a prospective cohort study.
BMC Musculoskelet Disord. 2020 Aug 3;21(1):515.

Kato S, Demura S, Kurokawa Y, Takahashi N, Shinmura K, Yokogawa N, Yonezawa N, Shimizu T, Kitagawa R, Tsuchiya H.
Efficacy and Safety of Abdominal Trunk Muscle Strengthening Using an Innovative Device in Elderly Patients With Chronic Low Back Pain: A Pilot Study.
Ann Rehabil Med. 2020 Jun;44(3):246-255.

Kato S, Inaki A, Murakami H, Kurokawa Y, Mochizuki T, Demura S, Yoshioka K, Yokogawa N, Yonezawa N, Shimizu T, Kinuya S, Tsuchiya H.
Reliability of the muscle strength measurement and effects of the strengthening by an innovative exercise device for the abdominal trunk muscles.
J Back Musculoskelet Rehabil. 2020;33(4):677-684.

Shinmura K, Kato S, Demura S, Yokogawa N, Yonezawa N, Shimizu T, Oku N, Kitagawa R, Handa M, Annen R, Murakami H, Tsuchiya H.
Revision surgery for instrumentation failure after total en bloc spondylectomy: a retrospective case series.　
BMC Musculoskelet Disord. 2020 Sep 2;21(1):591.

Ota T, Demura S, Kato S, Yoshioka K, Hayashi H, Inoue K, Shinmura K, Yokogawa N, Shirai T, Murakami H, Tsuchiya H.
A comparison of bone conductivity on titanium screws inserted into the vertebra using different surface processing.
J Exp Orthop. 2020 May 13;7(1):29.

Yonezawa N, Murakami H, Demura S, Kato S, Yoshioka K, Shinmura K, Yokogawa N, Shimizu T, Oku N, Kitagawa R, Handa M, Annen R, Kurokawa Y, Tsuchiya H.
Perioperative Complications and Prognosis of Curative Surgical Resection for Spinal Metastases in Elderly Patients.
World Neurosurg. 2020 Jan 23. pii: S1878-8750(20)30111-X.

Shimizu T, Demura S, Kato S, Shinmura K, Yokogawa N, Yonezawa N, Oku N, Kitagawa R, Handa M, Annen R, Nojima T, Murakami H, Tsuchiya H.
Radiation Disrupts the Protective Function of the Spinal Meninges in a Mouse Model of Tumor-induced Spinal Cord Compression.
Clin Orthop Relat Res. 2021 Jan 1;479(1):163-176.

Shimizu T, Kato S, Demura S, Shinmura K, Yokogawa N, Kurokawa Y, Yonezawa N, Oku N, Kitagawa R, Handa M, Annen R, Okamoto Y, Murakami H, Tsuchiya H.
The efficacy of surgical treatment on locomotive syndrome and physical function in patients with lumbar spinal canal stenosis.
J Orthop Sci. 2020 Apr 27:S0949-2658(20)30119-6. Online ahead of print.

Kurokawa Y, Murakami H, Demura S, Kato S, Yokogawa N, Shinmura K, Shimizu T, Tsuchiya H.
Risk factors for poor outcomes of early rehabilitation after total en bloc spondylectomy: a retrospective chart review of 140 patients. Spinal Cord.
2020 Aug;58(8):900-907.

Handa M, Demura S, Kato S, Shinmura K, Yokogawa N, Yonezawa N, Shimizu T, Oku N, Kitagawa R, Annen R, Murakami H, Kawahara N, Tsuchiya H.
Long-term outcomes of excision surgery for aggressive vertebral hemangiomas.
World Neurosurg. 2020 Jul 17:S1878-8750(20)31598-9. Online ahead of print.

Uto T, Tokuumi Y, Komine N, Yonezawa N, Demura S, Tsuchiya H.
Spontaneous Incidence of Vertebral Body Infection Following Osteoporotic Vertebral Fracture: A Case Series Study and Review of Literature.
Spine (Phila Pa 1976). 2020 Jun 15;45(12):E684-E687.

Matsumoto H, Kawakami N, Saito T, Uno K, Suzuki T, Watanabe K, Matsumoto M, Yamaguchi T, Yanagida H, Kotani T, Demura S, Takeshita K, Taniguchi Y.
Short fusion with vertebrectomy during growth in congenital spinal deformity: is early surgical intervention recommended?
Spine Deform. 2020 Aug;8(4):733-742.

Tauchi R, Kawakami N, Suzuki T, Uno K, Yamaguchi T, Yanagida H, Yamamoto T, Murakami H, Demura S, Kotani T.
NPO Japan Spinal Deformity Institute. Comparison of Early Definitive Fusion and Traditional Growing Rods in Early-onset Dystrophic Scoliosis in Neurofibromatosis Type 1: A Preliminary Report.
J Pediatr Orthop. 2020 Nov/Dec;40(10):569-574.

Okada E, Suzuki T, Demura S, Saito T, Nohara A, Tsuji T, Uno K, Kawakami N, Matsumoto M, Watanabe K.
Excessive correction impacts postoperative shoulder imbalance in lenke type 5C adolescent idiopathic scoliosis.
J Orthop Sci. 2020 Sep;25(5):757-762.

Taniguchi Y, Ohara T, Suzuki S, Watanabe K, Suzuki T, Uno K, Yamaguchi T, Yanagida H, Nakayama K, Kotani T, Watanabe K, Hirano T, Yamamoto T, Kawamura I, Sugawara R, Takeshita K, Demura S, Oku N, Sato T, Fujiwara K, Akazawa T, Murakami H, Kakutani K, Matsubayashi Y, Kawakami N.
Incidence and Risk Factors for Unplanned Return to the Operating Room Following Primary Definitive Fusion for Pediatric Spinal Deformity: A Multicenter Study with Minimum 2-year Follow-Up.
Spine (Phila Pa 1976). 2021 Apr 15;46(8):E498-E504.

HHikata T, Ishii K, Matsumoto M, Kobayashi K, Imagama S, Ando K, Ishiguro N, Yamashita M, Seki S, Terai H, Suzuki A, Tamai K, Aramomi M, Ishikawa T, Kimura A, Inoue H, Inoue G, Miyagi M, Saito W, Yamada K, Hongo M, Endo K, Suzuki H, Nakano A, Watanabe K, Ohya J, Chikuda H, Aoki Y, Shimizu M, Futatsugi T, Mukaiyama K, Hasegawa M, Kiyasu K, Iizuka H, Kobayashi R, Iizuka Y, Nishida K, Kakutani K, Nakajima H, Murakami H, Demura S, Kato S, Yoshioka K, Namikawa T, Watanabe K, Nakanishi K, Nakagawa Y, Yoshimoto M, Fujiwara H, Nishida N, Imajo Y, Yamazaki M, Abe T, Fujii K, Kaito T, Eguchi Y, Furuya T, Orita S, Ohtori S.
Risk Factor for Poor Patient Satisfaction After Lumbar Spine Surgery in Elderly Patients Aged Over 80 years.
Clin Spine Surg. 2021 May 1;34(4):E223-E228.

Ando K, Imagama S, Kaito T, Takenaka S, Sakai K, Shindo S, Watanabe K, Matsumoto M, Nakashima H, Wada K, Kimura A, Takeshita K, Kato S, Murakami H, Takeuchi K, Takahata M, Koda M, Yamazaki M, Watanabe M, Fujibayashi S, Furuya T, Kawaguchi Y, Matsuyama Y, Yoshii T, Okawa A.
Outcomes of Surgery for Thoracic Myelopathy Due to Thoracic Ossification of The Ligamentum Flavum in a Nationwide Multicenter Prospectively Collected Study in 223 Patients: Is Instrumented Fusion Necessary?
Spine (Phila Pa 1976). 2020 Feb 1;45(3):E170-E178.

Hirai T, Yoshii T, Ushio S, Mori K, Maki S, Katsumi K, Nagoshi N, Takeuchi K, Furuya T, Watanabe K, Nishida N, Watanabe K, Kaito T, Kato S, Nagashima K, Koda M, Ito K, Imagama S, Matsuoka Y, Wada K, Kimura A, Ohba T, Katoh H, Matsuyama Y, Ozawa H, Haro H, Takeshita K, Watanabe M, Matsumoto M, Nakamura M, Yamazaki M, Okawa A, Kawaguchi Y.
Clinical characteristics in patients with ossification of the posterior longitudinal ligament: A prospective multi-institutional cross-sectional study.
Sci Rep. 2020 Mar 26;10(1):5532.

Nishitani K, Ishikawa M, Morita Y, Yokogawa N, Xie C, de Mesy Bentley KL, Ito H, Kates SL, Daiss JL, Schwarz EM.
IsdB antibody-mediated sepsis following S. aureus surgical site infection.
JCI Insight. 2020 Oct 2;5(19):e141164.

Demura S, Watanabe K, Suzuki T, Saito T, Yamamoto T, Kotani T, Nohara A, Tsuji T, Ogura Y, Tsuchiya H, Uno K, Matsumoto M, Kawakami N; Japan Spinal Deformity Institute.
Comparison of Pulmonary Function After Selective Anterior Versus Posterior Fusion for the Correction of Thoracolumbar and Lumbar Adolescent Idiopathic Scoliosis.
Global Spine J. 2020 Jun;10(4):433-437.

2019年

Kato S, Demura S, Kurokawa Y, Shinmura K, Yokogawa N, Yonezawa N, Shimizu T, Oku N, Kitagawa R, Matsubara H, Kabata T, Tsuchiya H.
Correlation between osteoporotic vertebral fracture and abdominal trunk muscle strength in middle-aged and older women.
Arch Osteoporos. 2019 Oct 31;14(1):106.

Kato S, Demura S, Matsubara H, Inaki A, Shinmura K, Yokogawa N, Murakami H, Kinuya S, Tsuchiya H.
Utility of bone SPECT/CT to identify the primary cause of pain in elderly patients with degenerative lumbar spine disease.
J Orthop Surg Res. 2019 Jun 20;14(1):185.

Kato S, Murakami H, Demura S, Yoshioka K, Yokogawa N, Takaki S, Oku N, Tsuchiya H.
Indication for anterior spinal cord decompression via a posterolateral approach for the treatment of ossification of the posterior longitudinal ligament in the thoracic spine: a prospective cohort study.
Eur Spine J. 2020 Jan;29(1):113-121.

Kato S, Murakami H, Demura S, Yoshioka K, Shinmura K, Yokogawa N, Igarashi T, Yonezawa N, Shimizu T, Tsuchiya H.
Abdominal trunk muscle weakness and its association with chronic low back pain and risk of falling in older women.
BMC Musculoskelet Disord. 2019 Jun 3;20(1):273.

Kato S, Murakami H, Demura S, Ota T, Takahashi N, Yoshioka K, Shinmura K, Yokogawa N, Kawahara N, Tomita K, Tsuchiya H.
Motor and Sensory Impairments of the Lower Extremities After L2 Nerve Root Transection During Total en Bloc Spondylectomy.
Spine (Phila Pa 1976). 2019 Aug 15;44(16):1129-1136.

Kato S, Murakami H, Demura S, Yoshioka K, Yokogawa N, Yonezawa N, Shimizu T, Oku N, Kitagawa R, Tsuchiya H.
Kidney and Thyroid Cancer-Specific Treatment Algorithm for Spinal Metastases: A Validation Study.
World Neurosurg. 2019 Feb;122:e1305-e1311.

Yoshioka K, Murakami H, Demura S, Kato S, Kawashima H, Sanada S, Tsuchiya H.
The Large Individual Differences in the Range of Hip Joint Motion Rather Than Lumbar Spine Motion Affect Dynamic Spinopelvic Rhythm.
Spine Surg Relat Res. 2019 Mar 22;3(3):255-260.

Yonezawa N, Murakami H, Demura S, Kato S, Yoshioka K, Takeuchi A, Shinmura K, Yokogawa N, Shimizu T, Oku N, Kitagawa R, Handa M, Tsuchiya H.
Morphologic Changes After Denosumab Therapy in Patients with Giant Cell Tumor of the Spine: Report of Four Cases and a Review of the Literature.
World Neurosurg. 2019 Jul;127:38-46.

Yonezawa N, Murakami H, Sangsin A, Mizukoshi E, Tsuchiya H.
Lung metastases regression with increased CD8+ T lymphocyte infiltration following preoperative spinal embolization and total en bloc spondylectomy using tumor-bearing frozen autograft in a patient with spinal metastatic leiomyosarcoma.
Eur Spine J. 2019 Jun;28(Suppl 2):41-50.

Shimizu T, Yoshioka K, Murakami H, Demura S, Kato S, Yokogawa N, Oku N, Kitagawa R, Tsuchiya H.
Fluoroscopy-assisted posterior percutaneous reduction for the management of unilateral cervical facet dislocations after unsuccessful closed reduction: A case report.
Int J Surg Case Rep. 2019;58:212-215.

Yamamuro Y, Demura S, Murakami H, Kato S, Yonezawa N, Yokogawa N, Tsuchiya H.
Acute progressive adolescent idiopathic cervical kyphosis: case report.
J Neurosurg Spine. 2019 Feb 22:1-5.

Takagi Y, Yamada H, Ebara H, Hayashi H, Kidani S, Okamoto S, Nakamura Y, Kitano Y, Kagechika K, Demura S, Ueno T, Shimozaki K, Tsuchiya H.
Aspergillus terreus spondylodiscitis following an abdominal stab wound: a case report.
J Med Case Rep. 2019 Jun 5;13(1):172.

Kou I, Otomo N, Takeda K, Momozawa Y, Lu HF, Kubo M, Kamatani Y, Ogura Y, Takahashi Y, Nakajima M, Minami S, Uno K, Kawakami N, Ito M, Yonezawa I, Watanabe K, Kaito T, Yanagida H, Taneichi H, Harimaya K, Taniguchi Y, Shigematsu H, Iida T, Demura S, Sugawara R, Fujita N, Yagi M, Okada E, Hosogane N, Kono K, Nakamura M, Chiba K, Kotani T, Sakuma T, Akazawa T, Suzuki T, Nishida K, Kakutani K, Tsuji T, Sudo H, Iwata A, Sato T, Inami S, Matsumoto M, Terao C, Watanabe K, Ikegawa S.
Genome-wide association study identifies 14 previously unreported susceptibility loci for adolescent idiopathic scoliosis in Japanese.
Nat Commun. 2019 Aug 15;10(1):3685.

Takeda K, Kou I, Otomo N, Grauers A, Fan YH, Ogura Y, Takahashi Y, Momozawa Y, Einarsdottir E, Kere J; Japan Scoliosis Clinical Research Group (JSCRG), Matsumoto M, Qiu Y, Song YQ, Gerdhem P, Watanabe K, Ikegawa S.
A multiethnic meta-analysis defined the association of rs12946942 with severe adolescent idiopathic scoliosis.
TJ Hum Genet. 2019 May;64(5):493-498.

​2018年

Shinmura K, Murakami H, Demura S, Kato S, Yoshioka K, Hayashi H, Inoue K, Ota T, Yokogawa N, Ishii T, Igarashi T, Tsuchiya H.
A histological examination of spinal reconstruction using a frozen bone autograft.
PLoS One. 2018 Jan 25;13(1):e0191679.

Yokogawa N, Murakami H, Demura S, Kato S, Yoshioka K, Tsuchiya H.
Incidental durotomy during total en bloc spondylectomy.
Spine J. 2018 Mar;18(3):381-386.

Yokogawa N, Murakami H, Demura S, Kato S, Yoshioka K, Shimizu T, Oku N, Kitagawa R, Tsuchiya H.
Total spondylectomy for Enneking stage III giant cell tumor of the mobile spine.
Eur Spine J. 2018 Dec;27(12):3084-3091.

Igarashi T, Murakami H, Demura S, Kato S, Yoshioka K, Yokogawa N, Tsuchiya H.
Risk factors for local recurrence after total en bloc spondylectomy for metastatic spinal tumors: A retrospective study.
J Orthop Sci. 2018 May;23(3):459-463.

Shimizu T, Murakami H, Demura S, Kato S, Yoshioka K, Yokogawa N, Kawahara N, Tomita K, Tsuchiya H.
Total en bloc spondylectomy for primary tumors of the lumbar spine.
Medicine (Baltimore). 2018 Sep;97(37):e12366.

Shimizu T, Murakami H, Sangsin A, Demura S, Kato S, Shinmura K, Yokogawa N, Oku N, Kitagawa R, Tsuchiya H.
En bloc corpectomy for late gastrointestinal stromal tumor metastasis: a case report and review of the literature.
J Med Case Rep. 2018 Oct 16;12(1):300.

Kobayashi M, Kato S, Murakami H, Demura S, Yoshioka K, Yonezawa N, Takahashi N, Shimizu T, Tsuchiya H.
Delayed-Onset Paraplegia Due to Spinal Cord Infarction After Repeated Tumor Excision Surgeries of the Thoracic Spine.
Orthopedics. 2019 Jan 1;42(1):e131-e134.

Minehiro K, Demura S, Ichikawa K, Sasagawa T, Takahashi N, Minami S, Murakami H, Tsuchiya H.
Dose Reduction Protocol for Full Spine X-ray Examination Using Copper Filters in Patients With Adolescent Idiopathic Scoliosis.
Spine (Phila Pa 1976). 2019 Feb 1;44(3):203-210.

Sangsin A, Murakami H, Shimizu T, Kato S, Tsuchiya H.
Four-Year Survival of a Patient With Spinal Metastatic Acinic Cell Carcinoma After a Total En Bloc Spondylectomy and Reconstruction With a Frozen Tumor-Bearing Bone Graft.
Orthopedics. 2018 Sep 1;41(5):e727-e730.

Sangsin A, Murakami H, Shimizu T, Kato S, Demura S, Tsuchiya H.
Surgical Technique of Vertebral Body Removal and Anterior Reconstruction in L5 Spondylectomy.
Spine Surg Relat Res. 2018 Jul 27;2(3):236-242.

Akazawa T, Watanabe K, Matsumoto M, Tsuji T, Kawakami N, Kotani T, Sakuma T, Yamamoto T, Demura S, Orita S, Fujimoto K, Shiga Y, Niki H.
Spinal Deformity Institute study group. Modic changes and disc degeneration in adolescent idiopathic scoliosis patients who reach middle age without surgery: Can residual deformity cause lumbar spine degeneration?
J Orthop Sci. 2018 Nov;23(6):884-888.

Ogura Y, Takeda K, Kou I, Khanshour A, Grauers A, Zhou H, Liu G, Fan YH, Zhou T, Wu Z, Takahashi Y, Matsumoto M.
Scoliosis Clinical Research Group (JSCRG); Texas Scottish Rite Hospital for Children Clinical Group (TSRHCCG), Einarsdottir E, Kere J, Huang D, Qiu G, Xu L, Qiu Y, Wise CA, Song YQ, Wu N, Su P, Gerdhem P, Watanabe K, Ikegawa S. An international meta-analysis confirms the association of BNC2 with adolescent idiopathic scoliosis.
Sci Rep. 2018 Mar 16;8(1):4730.

Hashimoto S, Honda K, Fujita K, Miyachi Y, Isoda K, Misaka K, Suga Y, Kato S, Tsuchiya H, Kato Y, Okajima M, Taniguchi T, Shimada T, Sai Y.
Effect of coadministration of rifampicin on the pharmacokinetics of linezolid: clinical and animal studies.
J Pharm Health Care Sci. 2018 Nov 12;4:27.

Sangsin A, Saiudom D, Pongmanee S, Saengsin J, Leerapun T, Murakami H.
Natural History and Prognostic Factors of Cholangiocarcinoma With Spinal Metastasis: A 10-Year Single Center Study.
Clin Spine Surg. 2018 Apr;31(3):E160-E165.

Imagama S, Ando K, Takeuchi K, Kato S, Murakami H, Aizawa T, Ozawa H, Hasegawa T, Matsuyama Y, Koda M, Yamazaki M, Chikuda H, Shindo S, Nakagawa Y, Kimura A, Takeshita K, Wada K, Katoh H, Watanabe M, Yamada K, Furuya T, Tsuji T, Fujibayashi S, Mori K, Kawaguchi Y, Watanabe K, Matsumoto M, Yoshii T, Okawa A. Perioperative Complications After Surgery for Thoracic Ossification of Posterior Longitudinal Ligament: A Nationwide Multicenter Prospective Study.
Spine (Phila Pa 1976). 2018 Dec 1;43(23):E1389-E1397.

Uto T, Yonezawa N, Komine N, Tokuumi Y, Torigoe K, Koda Y, Tsuchiya H.
A delayed-onset intracranial chronic subdural hematoma following a lumbar spinal subdural hematoma: A case report.
Medicine (Baltimore). 2018 Sep;97(38):e12479.

2017年

Murakami H, Fujimaki Y, Yoshioka K, Kawahara N, Tsuchiya H.
Reconstruction using frozen tumour-bearing vertebra en bloc after total spondylectomy.
J Orthop Sci. 2017 Jan;22(1):156-159.

Demura S, Murakami H, Kato S, Yoshioka K, Yonezawa N, Takahashi N, Tsuchiya H.
Spontaneous derotation of compensatory lumbar curve after thoracic fusion in adolescent idiopathic scoliosis.
Spine Surg Relat Res. 2017 Dec 20;1(1):27-30.

Kato S, Murakami H, Inaki A, Mochizuki T, Demura S, Nakase J, Yoshioka K, Yokogawa N, Igarashi T, Takahashi N, Yonezawa N, Kinuya S, Tsuchiya H.
Innovative exercise device for the abdominal trunk muscles: An early validation study.
PLoS One. 2017 Feb 24;12(2):e0172934.

Yoshioka K, Murakami H, Demura S, Kato S, Yokogawa N, Kawahara N, Tomita K, Tsuchiya H.
Risk factors of instrumentation failure after multilevel total en bloc spondylectomy.
Spine Surg Relat Res. 2017 Dec 20;1(1):31-39.

Yokogawa N, Murakami H, Demura S, Kato S, Yoshioka K, Tsuchiya H.
Incidental durotomy during total en bloc spondylectomy.
Spine J. 2018 Mar;18(3):381-386.

Yonezawa N, Murakami H, Kato S, Takeuchi A, Tsuchiya H.
Giant cell tumor of the thoracic spine completely removed by total spondylectomy after neoadjuvant denosumab therapy.
Eur Spine J. 2017 May;26(Suppl 1):236-242.

Sugita S, Murakami H, Yonezawa N, Demura S, Tanaka S, Tsuchiya H.
Radical surgery consisting of en bloc corpectomy in recurrence after palliative surgery for spinal metastasis.
Spine Surg Relat Res. 2017 Dec 20;1(2):96-99.

Rosario M, Takeuchi A, Yamamoto N, Hayashi K, Miwa S, Higuchi T, Abe K, Taniguchi Y, Aiba H, Tanzawa Y, Murakami H, Tsuchiya H.
Pathogenesis of Osteosclerotic Change Following Treatment with an Antibody Against RANKL for Giant Cell Tumour of the Bone.
Anticancer Res. 2017 Feb;37(2):749-754.

Rosario MS, Murakami H, Kato S, Fujii M, Yonezawa N, Tsuchiya H.
Solitary thoracic intramedullary spinal neurofibroma microsurgically extirpated via recapping T-saw laminoplasty.
J Orthop Surg (Hong Kong). 2017 Jan;25(1):2309499017691003.

Kobayashi K, Imagama S, Ando K, Ishiguro N, Yamashita M, Eguchi Y, Matsumoto M, Ishii K, Hikata T, Seki S, Terai H, Suzuki A, Tamai K, Aramomi M, Ishikawa T, Kimura A, Inoue H, Inoue G, Miyagi M, Saito W, Yamada K, Hongo M, Matsuoka Y, Suzuki H, Nakano A, Watanabe K, Chikuda H, Ohya J, Aoki Y, Shimizu M, Futatsugi T, Mukaiyama K, Hasegawa M, Kiyasu K, Iizuka H, Iizuka Y, Kobayashi R, Nishida K, Kakutani K, Nakajima H, Murakami H, Demura S, Kato S, Yoshioka K, Namikawa T, Watanabe K, Nakanishi K, Nakagawa Y, Yoshimoto M, Fujiwara H, Nishida N, Imajo Y, Yamazaki M, Sakane M, Abe T, Fujii K, Kaito T, Furuya T, Orita S, Ohtori S.
Risk Factors for Delirium After Spine Surgery in Extremely Elderly Patients Aged 80 Years or Older and Review of the Literature: Japan Association of Spine Surgeons with Ambition Multicenter Study.
Global Spine J. 2017 Sep;7(6):560-566.

Kobayashi K, Imagama S, Ando K, Ishiguro N, Yamashita M, Eguchi Y, Matsumoto M, Ishii K, Hikata T, Seki S, Terai H, Suzuki A, Tamai K, Aramomi M, Ishikawa T, Kimura A, Inoue H, Inoue G, Miyagi M, Saito W, Yamada K, Hongo M, Nishimura H, Suzuki H, Nakano A, Watanabe K, Chikuda H, Ohya J, Aoki Y, Shimizu M, Futatsugi T, Mukaiyama K, Hasegawa M, Kiyasu K, Iizuka H, Iizuka Y, Kobayashi R, Nishida K, Kakutani K, Nakajima H, Murakami H, Demura S, Kato S, Yoshioka K, Namikawa T, Watanabe K, Nakanishi K, Nakagawa Y, Yoshimoto M, Fujiwara H, Nishida N, Imajo Y, Yamazaki M, Sakane M, Abe T, Fujii K, Kaito T, Furuya T, Orita S, Ohtori S.
Complications Associated With Spine Surgery in Patients Aged 80 Years or Older: Japan Association of Spine Surgeons with Ambition (JASA) Multicenter Study.
Global Spine J. 2017 Oct;7(7):636-641.

Imajo Y, Taguchi T, Neo M, Otani K, Ogata T, Ozawa H, Miyakoshi N, Murakami H, Iguchi T.
Complications of spinal surgery for elderly patients with lumbar spinal stenosis in a super-aging country: An analysis of 8033 patients.
J Orthop Sci. 2017 Jan;22(1):10-15.

Imajo Y, Taguchi T, Neo M, Otani K, Ogata T, Ozawa H, Miyakoshi N, Murakami H, Iguchi T.
Surgical and general complications in 2,961 Japanese patients with cervical spondylotic myelopathy: Comparison of different age groups.
Spine Surg Relat Res. 2017 Dec 20;1(1):7-13.

Takahashi Y, Kou I, Ogura Y, Miyake A, Takeda K, Nakajima M, Minami S, Kawakami N, Uno K, Ito M, Yonezawa I, Kaito T, Yanagida H, Watanabe K, Taneichi H, Harimaya K, Taniguchi Y, Kotani T, Tsuji T, Suzuki T, Sudo H, Fujita N, Yagi M, Chiba K, Kono K, Sakuma T, Akazawa T, Nishida K, Kakutani K, Shigematsu H, Iida T, Demura S, Hosogane N, Okada E, Nakamura M, Matsumoto M, Watanabe K, Ikegawa S.
A Replication Study for the Association of rs11190870 With Curve Severity in Adolescent Idiopathic Scoliosis in Japanese.
Spine (Phila Pa 1976). 2018 May 15;43(10):688-692.

2016年

Demura S, Murakami H, Kato S, Yoshioka K, Fujii M, Igarashi T, Yonezawa N, Takahashi N, Tsuchiya H.
Posterior curve correction using convex posterior hemi-interbody arthrodesis in skeletally immature patients with scoliosis.
Spine J. 2016 Sep;16(9):1152-6.

Kato S, Murakami H, Demura S, Nambu K, Fujimaki Y, Yoshioka K, Kawahara N, Tomita K, Tsuchiya H.
Spinal metastasectomy of renal cell carcinoma: A 16-year single center experience with a minimum 3-year follow-up.
J Surg Oncol. 2016 Apr;113(5):587-92.

Kato S, Murakami H, Demura S, Fujimaki Y, Yoshioka K, Yokogawa N, Tsuchiya H.
The impact of complete surgical resection of spinal metastases on the survival of patients with thyroid cancer.
Cancer Med. 2016 Sep;5(9):2343-9.

Kato S, Gasbarrini A, Ghermandi R, Gambarotti M, Bandiera S.
Spinal chordomas dedifferentiated to osteosarcoma: a report of two cases and a literature review.
Eur Spine J. 2016 May;25 Suppl 1:251-6.

Shinmura K, Murakami H, Tsuchiya H.
Second-Generation Total En Bloc Spondylectony (Second-generation TES).
In: Landriel FA and Vecchi E. editors. Frontiers in Neurosurgery, Volume 2–[Video Atlas of Spine Surgical Techniques]. Bentham Science Publishers; 2016. p210-224

Ishii T, Murakami H, Demura S, Kato S, Yoshioka K, Fujii M, Igarashi T, Tsuchiya H.
Invasiveness Reduction of Recent Total En Bloc Spondylectomy: Assessment of the Learning Curve.
Asian Spine J. 2016 Jun;10(3):522-7.

Sugita S, Murakami H, Kato S, Tanaka S, Tsuchiya H.
Disappearance of lung adenocarcinoma after total en bloc spondylectomy using frozen tumor-bearing vertebra for reconstruction.
Eur Spine J. 2016 May;25 Suppl 1:53-7.

Kitagawa R, Murakami H, Kato S, Nakada M, Demura S, Tsuchiya H.
En Bloc Resection and Reconstruction Using a Frozen Tumor-Bearing Bone for Metastases of the Spine and Cranium from Retroperitoneal Paraganglioma.
World Neurosurg. 2016 Jun;90:698.e1-698.e5.

2015年

Murakami H, Kawahara N, Tomita K.
Primary and Metastatic Tumors of the Spine: Total En Bloc Spondylectomy.
In: S.W. Wiesel. editor. Operative Techniques in Orthopaedic Surgery. 2nd edition. Lippincott Williams & Wilkins; 2015. pp2273-2283.

Demura S, Murakami H, Shirai T, Kato S, Yoshioka K, Ota T, Ishii T, Igarashi T, Tsuchiya H.
Surgical treatment for pyogenic vertebral osteomyelitis using iodine-supported spinal instruments: initial case series of 14 patients.
Eur J Clin Microbiol Infect Dis. 2015 Feb;34(2):261-6.

Demura S, Murakami H, Hayashi H, Kato S, Yoshioka K, Yokogawa N, Ishii T, Igarashi T, Fang X, Tsuchiya H.
Influence of Rod Contouring on Rod Strength and Stiffness in Spine Surgery.
Orthopedics. 2015 Jun;38(6):e520-3.

Kato S, Murakami H, Demura S, Yoshioka K, Hayashi H, Yokogawa N, Fang X, Tsuchiya H.
Gradual spinal cord decompression through migration of floated plaques after anterior decompression via a posterolateral approach for OPLL in the thoracic spine.
J Neurosurg Spine. 2015 Oct;23(4):479-83.

Yoshioka K, Murakami H, Demura S, Kato S, Tsuchiya H.
Prevalence and risk factors for development of venous thromboembolism after degenerative spinal surgery.
Spine (Phila Pa 1976). 2015 Mar 1;40(5):E301-6.

Yoshioka K, Murakami H, Demura S, Kato S, Tsuchiya H.
Mini-open transthoracic approach for resection of a calcified herniated thoracic disc and repair of the dural surface with fibrin glue: a case report.
J Orthop Surg (Hong Kong). 2015 Aug;23(2):243-6.

Yoshioka K, Murakami H, Demura S, Kato S, Kawahara N, Tomita K, Tsuchiya H.
Spinal Metastasis from Subcutaneous Sacrococcygeal Ependymoma: A Case Report with Long-Term Follow-Up.
Surg J (N Y). 2015 Nov 23;1(1):e50-e53.

Yoshioka K, Matsuda E, Murakami H, Tsuchiya H.
Microendoscopic Excision of Osteoid Osteoma in the Pedicle of the Third Lumbar Vertebra.
Asian Spine J. 2015 Dec;9(6):958-61.

Sasagawa T, Murakami H, Maruhashi Y, Segawa T, Yamamoto D, Shimizu S, Morita Y, Nakamura T.
Iatrogenic Lumbar Vertebral Fracture during Osteosynthesis for a Trochanteric Fracture of the Femur in Diffuse Idiopathic Skeletal Hyperostosis.
Asian Spine J. 2015 Oct;9(5):803-6.

Okamoto Y, Murakami H, Demura S, Kato S, Yoshioka K, Hayashi H, Sakamoto J, Kawahara N, Tsuchiya H.
The effect of kyphotic deformity because of vertebral fracture: a finite element analysis of a 10° and 20° wedge-shaped vertebral fracture model.
Spine J. 2015 Apr 1;15(4):713-20.

Hayashi H, Murakami H, Demura S, Kato S, Kawahara N, Tsuchiya H.
Outcome of posterior lumbar interbody fusion for L4-L5 degenerative spondylolisthesis.
Indian J Orthop. 2015 May-Jun;49(3):284-8.

Hayashi H, Murakami H, Demura S, Kato S, Yoshioka K, Shinmura K, Yokogawa N, Ishii T, Fang X, Shirai T, Tsuchiya H.
Surgical site infection after total en bloc spondylectomy: risk factors and the preventive new technology.
Spine J. 2015 Jan 1;15(1):132-7.

Hayashi H, Toribatake Y, Murakami H, Yoneyama T, Watanabe T, Tsuchiya H.
Gait Analysis Using a Support Vector Machine for Lumbar Spinal Stenosis.
Orthopedics. 2015 Nov;38(11):e959-64.

Shinmura K, Murakami H, Demura S, Kato S, Yoshioka K, Hayashi H, Yokogawa N, Igarashi T, Fujii M, Yonezawa N, Tsuchiya H.
Implantation of Liquid Nitrogen Frozen Tumor Tissue after Posterior Decompression and Stabilization for Metastatic Spinal Tumors.
Asian Spine J. 2015 Dec;9(6):869-75.

Yokogawa N, Toribatake Y, Murakami H, Hayashi H, Yoneyama T, Watanabe T, Tsuchiya H.
Differences in Gait Characteristics of Patients with Lumbar Spinal Canal Stenosis (L4 Radiculopathy) and Those with Osteoarthritis of the Hip.
PLoS One. 2015 Apr 20;10(4):e0124745.

Yokogawa N, Murakami H, Demura S, Kato S, Yoshioka K, Hayashi H, Ishii T, Igarashi T, Fang X, Tsuchiya H.
Postoperative Cerebrospinal Fluid Leakage Associated With Total En Bloc Spondylectomy.
Orthopedics. 2015 Jul 1;38(7):e561-6.

Yokogawa N, Murakami H, Demura S, Kato S, Yoshioka K, Yamamoto M, Iseki S, Tsuchiya H.
Effects of Radiation on Spinal Dura Mater and Surrounding Tissue in Mice.
PLoS One. 2015 Jul 27;10(7):e0133806.

Sugita S, Murakami H, Demura S, Kato S, Yoshioka K, Yokogawa N, Tanaka S, Tsuchiya H.
Repeated total en bloc spondylectomy for spinal metastases at different sites in one patient.
Eur Spine J. 2015 Oct;24(10):2196-200.

Kimura H, Fujibayashi S, Shimizu T, Otsuki B, Murakami H, Kaido T, Uemoto S, Matsuda S.
Successful Total En Bloc Spondylectomy of T7 Vertebra for Hepatocellular Carcinoma Metastasis After Living Donor Liver Transplantation.
Spine (Phila Pa 1976). 2015 Aug 15;40(16):E944-7.

2014年

Murakami H, Kato S, Ueda Y, Fujimaki Y, Tsuchiya H.
Reconstruction using a frozen tumor-bearing vertebra in total en bloc spondylectomy can enhance antitumor immunity.
Eur Spine J. 2014 May;23 Suppl 2:222-7.

Murakami H, Demura S, Kato S, Yoshioka K, Hayashi H, Inoue K, Ota T, Shinmura K, Yokogawa N, Fang X, Tsuchiya H.
Systemic antitumor immune response following reconstruction using frozen autografts for total en bloc spondylectomy.
Spine J. 2014 Aug 1;14(8):1567-71.

Murakami H, Tomita K, Kawahara N, Demura S.
En Bloc Spondylectomy: Single-Stage Thoracic Spine.
In: Ames CP, et al. editors. Spine and Spinal Cord Tumors: Advanced Management and Operative Techniques. QMP/ CRC Press; 2014. p719-734.

Demura S, Tomita K, Kawahara N, Murakami H.
Scoring System for Metastatic Tumors: Palliative or Aggressive Resection and Reconstruction.
In: Ames CP, et al. editors. Spine and Spinal Cord Tumors: Advanced Management and Operative Techniques. QMP/ CRC Press; 2014. p53-61.

Fujimaki Y, Murakami H, Tomita K, Kawahara N.
T-Saw Laminoplasty.
In: Ames CP, et al. editors. Spine and Spinal Cord Tumors: Advanced Management and Operative Techniques. QMP/ CRC Press; 2014. p487-495.

Kato S, Murakami H, Demura S, Yoshioka K, Kawahara N, Tomita K, Tsuchiya H.
More than 10-year follow-up after total en bloc spondylectomy for spinal tumors.
Ann Surg Oncol. 2014 Apr;21(4):1330-6.

Kato S, Murakami H, Demura S, Yoshioka K, Kawahara N, Tomita K, Tsuchiya H.
Patient-reported outcome and quality of life after total en bloc spondylectomy for a primary spinal tumour.
Bone Joint J. 2014 Dec;96-B(12):1693-8.

Kato S, Murakami H, Demura S, Yoshioka K, Hayashi H, Yokogawa N, Fang X, Tsuchiya H.
Vertebral Osteomyelitis Caused by Mycobacterium abscessus Surgically Treated Using Antibacterial Iodine-Supported Instrumentation.
Case Rep Orthop. 2014;2014:197061.

Sasagawa T, Hashimoto F, Nakamura T, Maruhasi Y, Matsumoto N, Segawa T, Yamamoto D, Goshima K, Murakami H, Tsuchiya H.
A pediatric case of single-level idiopathic cervical intervertebral disk calcification with symptom relapse 1 year after initial onset.
J Pediatr Orthop. 2014 Apr-May;34(3):282-6.

Yokogawa N, Murakami H, Demura S, Kato S, Yoshioka K, Hayashi H, Ishii T, Igarashi T, Fang X, Tsuchiya H.
Perioperative complications of total en bloc spondylectomy: adverse effects of preoperative irradiation.
PLoS One. 2014 Jun 3;9(6):e98797.

Yokogawa N, Murakami H, Demura S, Kato S, Yoshioka K, Hayashi H, Ishii T, Fujii M, Igarashi T, Tsuchiya H.
Motor function of the upper-extremity after transection of the second thoracic nerve root during total en bloc spondylectomy.
PLoS One. 2014 Oct 15;9(10):e109838.

Fang X, Murakami H, Demura S, Hayashi K, Matsubara H, Kato S, Yoshioka K, Inoue K, Ota T, Shinmura K, Tsuchiya H.
A novel method to apply osteogenic potential of adipose derived stem cells in orthopaedic surgery.
PLoS One. 2014 Feb 19;9(2):e88874.

Tawara D, Noro K, Tsujikami T, Okamoto Y, Murakami H.
Nonlinear mechanical analysis of posterior spinal instrumentation for osteoporotic vertebra: effects of mechanical properties of the rod on the failure risks around the screw.
Journal of Biomechanical Science and Engineering. 2014 9: 13-00163.

Ito Z, Higashino K, Kato S, Kim SS, Wong E, Yoshioka K, Hutton WC.
Pedicle screws can be 4 times stronger than lateral mass screws for insertion in the midcervical spine: a biomechanical study on strength of fixation.
J Spinal Disord Tech. 2014 Apr;27(2):80-5.

Sangadala S, Yoshioka K, Enyo Y, Liu Y, Titus L, Boden SD.
Characterization of a unique motif in LIM mineralization protein-1 that interacts with jun activation-domain-binding protein 1.
Mol Cell Biochem. 2014 Jan;385(1-2):145-57.

2013年

Tomita K, Kawahara N, Murakami H.
Primary and Metastatic Tumors of the Spine: Total En Bloc Spondylectomy.
In: J.M. Rhee, S.D. Boden, J.M. Flynn, S.W. Wiesel. editors. Operative Techniques in Spine Surgery. Lippincott Williams & Wilkins; 2013. P212-220.

Murakami H, Demura S, Kato S, Nishida H, Yoshioka K, Hayashi H, Inoue K, Ota T, Shinmura K, Yokogawa N, Fang X, Tsuchiya H.
Increase of IL-12 following reconstruction for total en bloc spondylectomy using frozen autografts treated with liquid nitrogen.
PLoS One. 2013 May 29;8(5):e64818.

Murakami H, Kato S, Demura S, Yoshioka K, Hayashi H, Inoue K, Ota T, Shinmura K, Yokogawa N, Fang X, Tsuchiya H.
Novel reconstruction technique using a frozen tumor-bearing vertebra from a total en bloc sponydylectomy for spinal tumors.
Orthopedics. 2013 Aug;36(8):605-7.

Demura S, Murakami H, Kawahara N, Kato S, Yoshioka K, Tsuchiya H.
Laminoplasty and pedicle screw fixation for cervical myelopathy associated with athetoid cerebral palsy: minimum 5-year follow-up.
Spine (Phila Pa 1976). 2013 Sep 15;38(20):1764-9.

Demura S, Takahashi K, Murakami H, Fujimaki Y, Kato S, Tsuchiya H.
The influence of steroid administration on systemic response in laminoplasty for cervical myelopathy.
Arch Orthop Trauma Surg. 2013 Aug;133(8):1041-5.

Demura S, Yaszay B, Carreau JH, Upasani VV, Bastrom TP, Bartley CE, Newton PO.
Maintenance of Thoracic Kyphosis in the 3D Correction of Thoracic Adolescent Idiopathic Scoliosis Using Direct Vertebral Derotation.
Spine Deform. 2013 Jan;1(1):46-50.

Demura S, Yaszay B, Bastrom TP, Carreau J, Newton PO; Harms Study Group.
Is decompensation preoperatively a risk in Lenke 1C curves?
Spine (Phila Pa 1976). 2013 May 15;38(11):E649-55.

Demura S, Bastrom TP, Schlechter J, Yaszay B, Newton PO; Harms Study Group.
Should postoperative pulmonary function be a criterion that affects upper instrumented vertebra selection in adolescent idiopathic scoliosis surgery?
Spine (Phila Pa 1976). 2013 Oct 15;38(22):1920-6.

Kato S, Murakami H, Demura S, Yoshioka K, Ota T, Shinmura K, Yokogawa N, Kawahara N, Tomita K, Tsuchiya H.
Patient and family satisfaction with en bloc total resection as a treatment for solitary spinal metastasis.
Orthopedics. 2013 Nov;36(11):e1424-30.

Kato S, Murakami H, Takeuchi A, Demura S, Yoshioka K, Kawahara N, Tomita K, Tsuchiya H.
Fifteen-year survivor of renal cell carcinoma after metastasectomies for multiple bone metastases.
Orthopedics. 2013 Nov;36(11):e1454-7.

Yoshioka K, Murakami H, Demura S, Kato S, Kawahara N, Tomita K, Tsuchiya H.
Clinical outcome of spinal reconstruction after total en bloc spondylectomy at 3 or more levels.
Spine (Phila Pa 1976). 2013 Nov 15;38(24):E1511-6.

Yoshioka K, Murakami H, Demura S, Kato S, Hayashi H, Inoue K, Ota T, Shinmura K, Yokogawa N, Fang X, Tsuchiya H.
Comparative study of the prevalence of venous thromboembolism after elective spinal surgery.
Orthopedics. 2013 Feb;36(2):e223-8.

Okayama T, Murakami H, Demura S, Kawahara N, Tomita K, Tsuchiya H.
A Biomechanical Study on Laminectomy and Dekyphosis for Thoracic Ossification of the Posterior Longitudinal Ligament.
Advances in Mechanical Engineering Vol. 2013, Article ID 928071, 2013

Sasagawa T, Hashimoto F, Nakamura T, Maruhasi Y, Matsumoto N, Segawa T, Yamamoto D, Goshima K, Murakami H, Tsuchiya H.
A pediatric case of single-level idiopathic cervical intervertebral disk calcification with symptom relapse 1 year after initial onset.
J Pediatr Orthop. 2014 Apr-May;34(3):282-6.

Karasugi T, Nakajima M, Ikari K; Genetic Study Group of Investigation Committee on Ossification of the Spinal Ligaments, Tsuji T, Matsumoto M, Chiba K, Uchida K, Kawaguchi Y, Mizuta H, Ogata N, Iwasaki M, Maeda S, Numasawa T, Abumi K, Kato T, Ozawa H, Taguchi T, Kaito T, Neo M, Yamazaki M, Tadokoro N, Yoshida M, Nakahara S, Endo K, Imagama S, Demura S, Sato K, Seichi A, Ichimura S, Watanabe M, Watanabe K, Nakamura Y, Mori K, Baba H, Toyama Y, Ikegawa S.
A genome-wide sib-pair linkage analysis of ossification of the posterior longitudinal ligament of the spine.
J Bone Miner Metab. 2013 Mar;31(2):136-43.

Wong E, Sangadala S, Boden SD, Yoshioka K, Hutton WC, Oliver C, Titus L.
A novel low-molecular-weight compound enhances ectopic bone formation and fracture repair.
J Bone Joint Surg Am. 2013 Mar 6;95(5):454-61.

2012年

Demura S, Kawahara N, Murakami H, Akamaru T, Kato S, Oda M, Tomita K, Tsuchiya H.
Giant cell tumor expanded into the thoracic cavity with spinal involvement.
Orthopedics. 2012 Mar 7;35(3):e453-6.

Ueda Y, Kawahara N, Murakami H, Demura S, Tsuchiya H.
Thoracic disk herniation with paraparesis treated with transthoracic microdiskectomy in a 14-year-old girl.
Orthopedics. 2012 May;35(5):e774-7.

Ueda Y, Murakami H, Demura S, Kawahara N, Tomita K, Tsuchiya H.
Eosinophilic granuloma of the lumbar spine in an adult.
Orthopedics. 2012 Dec;35(12):e1818-21.

Kato S, Murakami H, Demura S, Yoshioka K, Okamoto Y, Hayashi H, Tsuchiya H.
Epidural inflammatory pseudotumor in the thoracic spine in a patient with polymyalgia rheumatica.
Spine J. 2012 Jun;12(6):e1-4.

Kato S, Murakami H, Higashino K, Okada M, Ito Z, Demura S, Kawahara N, Tomita K, Tsuchiya H, Hutton WC.
The effect of spinal shortening after total en bloc spondylectomy: a biomechanical study in the thoracic spine.
J Spinal Disord Tech. 2012 Aug;25(6):E183-90.

Kato S, Murakami H, Minami T, Demura S, Yoshioka K, Matsui O, Tsuchiya H.
Preoperative embolization significantly decreases intraoperative blood loss during palliative surgery for spinal metastasis.
Orthopedics. 2012 Sep;35(9):e1389-95.

Kato S, Murakami H, Demura S, Yoshioka K, Hayashi H, Tsuchiya H.
Novel surgical technique for ossification of posterior longitudinal ligament in the thoracic spine.
J Neurosurg Spine. 2012 Dec;17(6):525-9.

Yoshioka K, Kawahara N, Murakami H, Demura S, Matsuda M, Tomita K.
A glass foreign body migrating into the lumbar spinal canal: a case report.
J Orthop Surg (Hong Kong). 2012 Aug;20(2):257-9.

Sasagawa T, Kunogi J, Masuyama S, Ogihara S, Takeuchi Y, Takeshita Y, Fukushima M, Kamiya N, Murakami H, Tsuchiya H.
The clinical utility of a one-shot energy subtraction method for thoracic spine radiography.
J Orthop Sci. 2012 Jul;17(4):346-51.

2011年

Kawahara N, Tomita K, Murakami H, Demura S, Yoshioka K, Kato S.
Total en bloc spondylectomy of the lower lumbar spine: a surgical techniques of combined posterior-anterior approach.
Spine (Phila Pa 1976). 2011 Jan 1;36(1):74-82.

Demura S, Kawahara N, Murakami H, Abdel-Wanis ME, Kato S, Yoshioka K, Tomita K, Tsuchiya H.
Total en bloc spondylectomy for spinal metastases in thyroid carcinoma.
J Neurosurg Spine. 2011 Feb;14(2):172-6.

Kato S, Sangadala S, Tomita K, Titus L, Boden SD.
A synthetic compound that potentiates bone morphogenetic protein-2-induced transdifferentiation of myoblasts into the osteoblastic phenotype.
Mol Cell Biochem. 2011 Mar;349(1-2):97-106.

Kato S, Kawahara N, Murakami H, Demura S, Yoshioka K, Okamoto Y, Tomita K, Tsuchiya H.
Extensive thoracolumbar spinal tuberculosis treated with two-stage surgery using a minimally invasive posterior instrumentation.
Eur J Orthop Surg Traumatol. 2011 21: 407-409.

Sasagawa T, Kunogi J, Masuyama S, Ogihara S, Takeuchi Y, Takeshita Y, Kamiya N, Murakami H, Tsuchiya H.
New computed radiography processing condition for whole-spine radiography.
Orthopedics. 2011 Dec 6;34(12):e906-10.

Furukawa Y, Hamaguchi A, Nozaki I, Iizuka T, Sasagawa T, Shima Y, Demura S, Murakami H, Kawahara N, Okuyama T, Iwasa K, Yamada M.
Cervical pachymeningeal hypertrophy as the initial and cardinal manifestation of mucopolysaccharidosis type I in monozygotic twins with a novel mutation in the alpha-L-iduronidase gene.
J Neurol Sci. 2011 Mar 15;302(1-2):121-5.

Hayashi Y, Nakada M, Mohri M, Murakami H, Kawahara N, Hamada J.
Ganglioglioma of the thoracolumbar spinal cord in a patient with neurofibromatosis type 1: a case report and literature review.
Pediatr Neurosurg. 2011;47(3):210-3.

Sakai K, Ono K, Okamoto Y, Murakami H, Yamada M.
Cervical flexion myelopathy in a patient showing apparent long tract signs: a severe form of Hirayama disease.
Joint Bone Spine. 2011 May;78(3):316-8.

Tawara D, Sakamoto J, Murakami H, Kawahara N, Tomita K.
Patient-specific finite element analyses detect significant mechanical therapeutic effects on osteoporotic vertebrae during a three-year treatment.
J of Biomechanical Science and Engineering. 2011 6: 248-261.

Fourney DR, Frangou EM, Ryken TC, Dipaola CP, Shaffrey CI, Berven SH, Bilsky MH, Harrop JS, Fehlings MG, Boriani S, Chou D, Schmidt MH, Polly DW, Biagini R, Burch S, Dekutoski MB, Ganju A, Gerszten PC, Gokaslan ZL, Groff MW, Liebsch NJ, Mendel E, Okuno SH, Patel S, Rhines LD, Rose PS, Sciubba DM, Sundaresan N, Tomita K, Varga PP, Vialle LR, Vrionis FD, Yamada Y, Fisher CG.
Spinal instability neoplastic score: an analysis of reliability and validity from the spine oncology study group.
J Clin Oncol. 2011 Aug 1;29(22):3072-7.

2010年

Tomita K, Kawahara N, Murakami H.
Primary and Metastatic Tumors of the Spine: Total En Bloc Spondylectomy.
In: S.W. Wiesel. editor. Operative Techniques in Orthopaedic Surgery. Lippincott Williams & Wilkins; 2010. P1846-1854.

Kawahara N, Tomita K, Murakami H, Demura S, Yoshioka K, Miyazaki T.
Total excision of a recurrent chondrosarcoma of the thoracic spine: a case report of a seven-year-old boy with fifteen years follow-up.
Spine (Phila Pa 1976). 2010 May 15;35(11):E481-7.

Murakami H, Kawahara N, Tomita K, Demura S, Kato S, Yoshioka K.
Does interruption of the artery of Adamkiewicz during total en bloc spondylectomy affect neurologic function?
Spine (Phila Pa 1976). 2010 Oct 15;35(22):E1187-92.

Murakami H, Kawahara N, Demura S, Kato S, Yoshioka K, Tomita K.
Total en bloc spondylectomy for lung cancer metastasis to the spine.
J Neurosurg Spine. 2010 Oct;13(4):414-7.

Murakami H, Kawahara N, Demura S, Kato S, Yoshioka K, Tomita K.
Neurological function after total en bloc spondylectomy for thoracic spinal tumors.
J Neurosurg Spine. 2010 Mar;12(3):253-6.

Murakami H, Kawahara N, Tomita K.
Editorial response.
J Neurosurg Spine. 2010 13: 412-413.

Murakami H, Kawahara N, Demura S, Kato S, Yoshioka K, Sasagawa T, Tomita K.
Perioperative complications and prognosis for elderly patients with spinal metastases treated by surgical strategy.
Orthopedics. 2010 Mar;33(3).

Kato S, Kawahara N, Murakami H, Demura S, Yoshioka K, Okayama T, Fujita T, Tomita K.
Surgical management of aggressive vertebral hemangiomas causing spinal cord compression: long-term clinical follow-up of five cases.
J Orthop Sci. 2010 May;15(3):350-6.

Kato S, Kawahara N, Murakami H, Demura S, Shirai T, Tsuchiya H, Tomita K.
Multi-level total en bloc spondylectomy for solitary lumbar metastasis of myxoid liposarcoma.
Orthopedics. 2010 Jun 9;33(6):446.

Yoshioka K, Kitajima I, Kabata T, Tani M, Kawahara N, Murakami H, Demura S, Tsubokawa T, Tomita K.
Venous thromboembolism after spine surgery: changes of the fibrin monomer complex and D-dimer level during the perioperative period.
J Neurosurg Spine. 2010 Nov;13(5):594-9.

Tawara D, Sakamoto J, Murakami H, Kawahara N, Oda J, Tomita K.
Mechanical evaluation by patient-specific finite element analyses demonstrates therapeutic effects for osteoporotic vertebrae.
J Mech Behav Biomed Mater. 2010 Jan;3(1):31-40.

Tawara D, Sakamoto J, Murakami H, Kawahara N, Oda J, Tomita K.
Mechanical Therapeutic Effects in Osteoporotic L1-Vertebrae Evaluated by Nonlinear Patient-specific Finite Element Analysis.
J of Biomechanical Science and Engineering. 2010 5: 499-514.