金沢大学附属病院 整形外科

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脊椎外科班

     
     
     
     
臨床
 
 脊椎グループでは、2019年の2月に大きな異動がありました。約9年間にわたり研究室を牽引してこられた村上英樹先生が名古屋市立大学整形外科主任教授に御就任され、名古屋へ栄転されました。私 (出村)を含め、今まで村上先生と共に働いてきた脊椎グループの先生方にとってもこれ以上ない喜びであります。しかし同時に、金沢大学脊椎グループから村上先生が抜けられた影響はとても大きく、残されたメンバーとして、今までのアクティビティーを落とすことの無いように頑張っていきたいと思います。
 現在、大学のメンバーは出村諭、加藤仁志先生、新村和也先生のスタッフ3名と清水貴樹先生、奥規博先生、北川亮先生、半田真人先生の大学院生4名、黒川由貴先生(リハビリ)を加え、計8名で頑張っています。また横川文彬先生が2018年4月より厚生労働省へ出向中であり孤軍奮闘されておられます。

 2018年の脊椎グループの手術件数は約200件あり、その多くは脊椎・脊髄腫瘍、側弯症、後弯症などの脊柱変形、脊柱靱帯骨化症、変性疾患に対する低侵襲手術でした。2018年2月以降、入院患者さんはスタッフ、大学院生を合わせ、大きく2グループにわけて受け持っています。外来は火曜日と木曜日の午前中に各3名が担当し、1日約50-60人の患者さんを診察しています。基本的には、脊椎疾患全般、側弯症などの脊柱変形を出村が担当し、脊椎腫瘍、靭帯骨化症、腰痛症を加藤先生が、内視鏡手術などの低侵襲手術、脊椎疾患全般を新村先生が担当しています。
 毎週木曜日の夜には医局で症例検討会を行なっております。大学内での手術症例や、学外での手術に迷った症例など、1例1例を全員で検討し、手術適応や術式を考えています。また毎月第1週には、大学院生の研究報告、第3週には、臨床研究・基礎研究に関する検討会を始めました。学外の先生方も症例のご相談や脊椎の臨床研究に関する等も含め、気軽にお越しいただければ幸いです。
 脊椎グループのスタッフの数は減りますが、従来からご紹介頂いていた脊椎腫瘍、側弯症などの脊柱変形、脊柱靭帯骨化症などの疾患以外でも、一般の変性疾患症例やお困りの症例がございましたら今まで以上に、是非ご紹介して頂ければ幸いです。
     
 
基礎研究・臨床研究
 
 現在の脊椎班の基礎・臨床研究ですが、8名の大学院生(学外3名、学内5名)が中心となってすすめています。脊椎班の基礎・臨床研究に対する方針は『臨床で遭遇した疑問・問題点を研究で解決する』というテーマですすめています。2018年は井上啓先生が、脊椎再建におけるチタンケージ内の骨癒合を脂肪由来幹細胞で促進できることを基礎実験で証明し、学位を取得しました。また新村和也先生は、液体窒素処理骨を併用した腫瘍脊椎骨全摘術(TES)の基礎実験を行い、骨癒合が得られることを証明し、学位論文としてPLoS Oneに掲載されました。太田敬先生は、当教室で開発したヨードコーティングスクリューの脊椎に挿入し、骨伝導能をみる実験が終了し、現在論文を作成しています。五十嵐峻先生は、放射線照射が脊椎の骨強度に与える影響を特に骨質に着目して基礎研究を行っており、実験結果もほぼまとまったため論文作成の準備にとりかかっています。米澤則隆先生は、液体窒素処理骨移植が全身のがん免疫に与える影響を基礎と臨床の両面から研究しています。学外大学院の3名の先生は、福井済生会病院、金沢済生会病院、浅ノ川総合病院で臨床でも大変忙しくされている中、頑張って研究をすすめてくれています。
 学内大学院の清水貴樹先生は、脊椎腫瘍進展における硬膜のバリア機構の放射線照射による影響を調べています。奥規博先生は龍谷大学理工学部との共同研究で骨粗鬆症性脊椎における多椎体脊椎固定術の力学的解析を行っています。北川亮先生は加藤先生が開発した体幹筋トレーニングベルトの腰痛改善効果を前向きに臨床研究で調査しています。半田真人先生は、従来の放射線治療と比べ、陽子線を用いた治療が脊椎組織に与える影響の違いを調べています。また、理学療法士の黒川由貴先生が脊椎班の院生として、TES術後のADL調査や回復過程などの臨床経過を理学療法に着目して研究しています。
 今後のテーマとしては金沢大学脊椎グループ伝統である脊椎腫瘍・脊柱靱帯骨化症に関連した研究に加え、脊柱変形や腰痛、脊椎変性疾患で感じた疑問、問題点を研究に結び付けていきたいと考えています。

 
     
 
業績
 
英語論文(2010~)
​2018年
  1.  
  2. Shinmura K, Murakami H, Demura S, Kato S, Yoshioka K, Hayashi H, Inoue K, Ota T, Yokogawa N, Ishii T, Igarashi T, Tsuchiya H: A histological examination of spinal reconstruction using a frozen bone autograft. PLoS One 13(1),e0191679,2018
  3.  
  4. Yokogawa N, Murakami H, Demura S, Kato S, Yoshioka K, Tsuchiya H: Incidental durotomy during total en bloc spondylectomy. Spine J. 18(3),381-386,2018
  5.  
  6. Yokogawa N, Murakami H, Demura S, Kato S, Yoshioka K, Shimizu T, Oku N, Kitagawa R, Tsuchiya H: Total spondylectomy for Enneking stage III giant cell tumor of the mobile spine. Eur Spine J. Sep 12. doi: 10.1007/s00586-018-5761-3,2018 [Epub ahead of print]
  7.  
  8. Igarashi T, Murakami H, Demura S, Kato S, Yoshioka K, Yokogawa N, Tsuchiya H: Risk factors for local recurrence after total en bloc spondylectomy for metastatic spinal tumors: A retrospective study. J Orthop Sci. 23(3),459-463,2018
  9.  
  10. Shimizu T, Murakami H, Demura S, Kato S, Yoshioka K, Yokogawa N, Kawahara N, Tomita K, Tsuchiya H: Total en bloc spondylectomy for primary tumors of the lumbar spine. Medicine (Baltimore) 97(37),e12366,2018
  11.  
  12. Shimizu T, Murakami H, Sangsin A, Demura S, Kato S, Shinmura K, Yokogawa N, Oku N, Kitagawa R, Tsuchiya H: En bloc corpectomy for late gastrointestinal stromal tumor metastasis: a case report and review of the literature. J Med Case Rep. 12(1),300. doi: 10.1186/s13256-018-1844-3,2018
  13.  
  14. Kobayashi M, Kato S, Murakami H, Demura S, Yoshioka K, Yonezawa N, Takahashi N, Shimizu T, Tsuchiya H: Delayed-Onset Paraplegia Due to Spinal Cord Infarction After Repeated Tumor Excision Surgeries of the Thoracic Spine. Orthopedics Oct 26,1-4. doi: 10.3928/01477447-20181023-07,2018 [Epub ahead of print]
  15.  
  16. Minehiro K, Demura S, Ichikawa K, Sasagawa T, Takahashi N, Minami S, Murakami H, Tsuchiya H: Dose Reduction Protocol for Full Spine X-ray Examination Using Copper Filters in Patients With Adolescent Idiopathic Scoliosis. Spine,doi: 10.1097/BRS.0000000000002787,2018 [Epub ahead of print]
  17.  
  18. Sangsin A, Murakami H, Shimizu T, Kato S, Tsuchiya H: Four-Year Survival of a Patient With Spinal Metastatic Acinic Cell Carcinoma After a Total En Bloc Spondylectomy and Reconstruction With a Frozen Tumor-Bearing Bone Graft Orthopedics 41: e727-e730, 2018
  19.  
  20. Sangsin A, Murakami H, Shimizu T, Kato S, Demura S, Tsuchiya H: Surgical Technique of Vertebral Body Removal and Anterior Reconstruction in L5 Spondylectomy. Spine Surg Relat Res 2: 236-242, 2018
  21.  
  22. Akazawa T, Watanabe K, Matsumoto M, Tsuji T, Kawakami N, Kotani T, Sakuma T, Yamamoto T, Demura S, Orita S, Fujimoto K, Shiga Y, Niki H; Japan Spinal Deformity Institute study group: Modic changes and disc degeneration in adolescent idiopathic scoliosis patients who reach middle age without surgery: Can residual deformity cause lumbar spine degeneration? J Orthop Sci. 23(6),884-888,2018
  23.  
  24. Ogura Y, Takeda K, Kou I, Khanshour A, Grauers A, Zhou H, Liu G, Fan YH, Zhou T, Wu Z, Takahashi Y, Matsumoto M; Japan Scoliosis Clinical Research Group (JSCRG); Texas Scottish Rite Hospital for Children Clinical Group (TSRHCCG), Einarsdottir E, Kere J, Huang D, Qiu G, Xu L, Qiu Y, Wise CA, Song YQ, Wu N, Su P, Gerdhem P, Watanabe K, Ikegawa S: An international meta-analysis confirms the association of BNC2 with adolescent idiopathic scoliosis. Sci Rep.8(1),4730.doi: 10.1038/s41598-018-22552-x,2018
  25.  
  26. Hashimoto S, Honda K, Fujita K, Miyachi Y, Isoda K, Misaka K, Suga Y, Kato S, Tsuchiya H, Kato Y, Okajima M, Taniguchi T, Shimada T, Sai Y. Effect of coadministration of rifampicin on the pharmacokinetics of linezolid: clinical and animal studies. J Pharm Health Care Sci 4:27, 2018. 
  27. Sangsin A, Saiudom D, Pongmanee S, Saengsin J, Leerapun T, Murakami H: Natural History and Prognostic Factors of Cholangiocarcinoma With Spinal Metastasis: A 10-Year Single Center Study. Clin Spine Surg 31: E160-E165, 2018
  28.  
  29. Imagama S, Ando K, Takeuchi K, Kato S, Murakami H, Aizawa T, Ozawa H, Hasegawa T, Matsuyama Y, Koda M, Yamazaki M, Chikuda H, Shindo S, Nakagawa Y, Kimura A, Takeshita K, Wada K, Katoh H, Watanabe M, Yamada K, Furuya T, Tsuji T, Fujibayashi S, Mori K, Kawaguchi Y, Watanabe K, Matsumoto M, Yoshii T, Okawa A: Perioperative Complications after Surgery for Thoracic Ossification of Posterior Longitudinal Ligament- Nationwide Multicenter Prospective Study. Spine (Phila Pa 1976) 43: E1389-E1397, 2018
  30.  
2017年
  1. Murakami H, Fujimaki Y, Yoshioka K, Kawahara N, Tsuchiya H. Reconstruction using frozen tumour-bearing vertebra en bloc after total spondylectomy. J Orthop Sci 22: 156-159, 2017
  2.  
  3. Demura S, Murakami H, Kato S, Yoshioka K, Yonezawa N, Takahashi N, Tsuchiya H. Spontaneous derotation of compensatory lumbar curve after thoracic fusion in adolescent idiopathic scoliosis. Spine Surg Relat Res 1: 27-30, 2017
  4.  
  5. Kato S, Murakami H, Inaki A, Mochizuki T, Demura S, Nakase J, Yoshioka K, Yokogawa N, Igarashi T, Takahashi N, Yonezawa N, Kinuya S, Tsuchiya H. Innovative exercise device for the abdominal trunk muscles: An early validation study. PLoS One 12: e0172934, 2017
  6.  
  7. Yoshioka K, Murakami H, Demura S, Kato S, Yokogawa N, Kawahara N, Tomita K, Tsuchiya H. Risk factors of instrumentation failure after multilevel total en bloc spondylectomy. Spine Surg Relat Res 1: 31-39, 2017
  8.  
  9. Yokogawa N, Murakami H, Demura S, Kato S, Yoshioka K, Tsuchiya H. Incidental durotomy during total en bloc spondylectomy. Spine J. 2017 Jul 20. [Epub ahead of print]
  10.  
  11. Yonezawa N, Murakami H, Kato S, Takeuchi A, Tsuchiya H. Giant cell tumor of the thoracic spine completely removed by total spondylectomy after neoadjuvant denosumab therapy. Eur Spine J 26(Suppl 1): 236-242, 2017
  12.  
  13. Sugita S, Murakami H, Yonezawa N, Demura S, Tanaka S, Tsuchiya H. Radical surgery consisting of en bloc corpectomy in recurrence after palliative surgery for spinal metastasis. Spine Surg Relat Res 1: 96-99, 2017
  14.  
  15. Rosario M, Takeuchi A, Yamamoto N, Hayashi K, Miwa S, Higuchi T, Abe K, Taniguchi Y, Aiba H, Tanzawa Y, Murakami H, Tsuchiya H. Pathogenesis of Osteosclerotic Change Following Treatment with an Antibody Against RANKL for Giant Cell Tumour of the Bone. Anticancer Res 37: 749-754, 2017
  16.  
  17. Rosario MS, Murakami H, Kato S, Fujii M, Yonezawa N, Tsuchiya H. Solitary thoracic intramedullary spinal neurofibroma microsurgically extirpated via recapping T-saw laminoplasty. J Orthop Surg (Hong Kong). 2017 Jan;25(1):2309499017691003
  18.  
  19. Kobayashi K, Imagama S, Ando K, Ishiguro N, Yamashita M, Eguchi Y, Matsumoto M, Ishii K, Hikata T, Seki S, Terai H, Suzuki A, Tamai K, Aramomi M, Ishikawa T, Kimura A, Inoue H, Inoue G, Miyagi M, Saito W, Yamada K, Hongo M, Matsuoka Y, Suzuki H, Nakano A, Watanabe K, Chikuda H, Ohya J, Aoki Y, Shimizu M, Futatsugi T, Mukaiyama K, Hasegawa M, Kiyasu K, Iizuka H, Iizuka Y, Kobayashi R, Nishida K, Kakutani K, Nakajima H, Murakami H, Demura S, Kato S, Yoshioka K, Namikawa T, Watanabe K, Nakanishi K, Nakagawa Y, Yoshimoto M, Fujiwara H, Nishida N, Imajo Y, Yamazaki M, Sakane M, Abe T, Fujii K, Kaito T, Furuya T, Orita S, Ohtori S. Risk Factors for Delirium After Spine Surgery in Extremely Elderly Patients Aged 80 Years or Older and Review of the Literature: Japan Association of Spine Surgeons with Ambition Multicenter Study. Global Spine J 7: 560-566, 2017
  20.  
  21. Kobayashi K, Imagama S, Ando K, Ishiguro N, Yamashita M, Eguchi Y, Matsumoto M, Ishii K, Hikata T, Seki S, Terai H, Suzuki A, Tamai K, Aramomi M, Ishikawa T, Kimura A, Inoue H, Inoue G, Miyagi M, Saito W, Yamada K, Hongo M, Nishimura H, Suzuki H, Nakano A, Watanabe K, Chikuda H, Ohya J, Aoki Y, Shimizu M, Futatsugi T, Mukaiyama K, Hasegawa M, Kiyasu K, Iizuka H, Iizuka Y, Kobayashi R, Nishida K, Kakutani K, Nakajima H, Murakami H, Demura S, Kato S, Yoshioka K, Namikawa T, Watanabe K, Nakanishi K, Nakagawa Y, Yoshimoto M, Fujiwara H, Nishida N, Imajo Y, Yamazaki M, Sakane M, Abe T, Fujii K, Kaito T, Furuya T, Orita S, Ohtori S. Complications Associated With Spine Surgery in Patients Aged 80 Years or Older: Japan Association of Spine Surgeons with Ambition (JASA) Multicenter Study. Global Spine J 7: 636-641, 2017
     
  22. Imajo Y, Taguchi T, Neo M, Otani K, Ogata T, Ozawa H, Miyakoshi N, Murakami H, Iguchi T. Complications of spinal surgery for elderly patients with lumbar spinal stenosis in a super-aging country: An analysis of 8033 patients. J Orthop Sci 22: 10-15, 2017
  23.  
  24. Imajo Y, Taguchi T, Neo M, Otani K, Ogata T, Ozawa H, Miyakoshi N, Murakami H, Iguchi T. Surgical and general complications in 2,961 Japanese patients with cervical spondylotic myelopathy: Comparison of different age groups. Spine Surg Relat Res 1: 7-13, 2017
  25.  
  26. Takahashi Y, Kou I, Ogura Y, Miyake A, Takeda K, Nakajima M, Minami S, Kawakami N, Uno K, Ito M, Yonezawa I, Kaito T, Yanagida H, Watanabe K, Taneichi H, Harimaya K, Taniguchi Y, Kotani T, Tsuji T, Suzuki T, Sudo H, Fujita N, Yagi M, Chiba K, Kono K, Sakuma T, Akazawa T, Nishida K, Kakutani K, Shigematsu H, Iida T, Demura S, Hosogane N, Okada E, Nakamura M, Matsumoto M, Watanabe K, Ikegawa S. A Replication Study for the Association of rs11190870 With Curve Severity in Adolescent Idiopathic Scoliosis in Japanese. Spine (Phila Pa 1976). 2017 Sep 8. doi: 10.1097/BRS.0000000000002413.

2016年
  1. Demura S, Murakami H, Kato S, Yoshioka K, Fujii M, Igarashi T, Yonezawa N, Takahashi N, Tsuchiya H. Posterior curve correction using convex posterior hemi-interbody arthrodesis in skeletally immature patients with scoliosis. Spine J 16: 1152-1156, 2016
  2.  
  3. Kato S, Murakami H, Demura S, Nambu K, Fujimaki Y, Yoshioka K, Kawahara N, Tomita K, Tsuchiya H. Spinal metastasectomy of renal cell carcinoma: A 16-year single center experience with a minimum 3-year follow-up. J Surg Oncol 113: 587-592, 2016
  4.  
  5. Kato S, Murakami H, Demura S, Fujimaki Y, Yoshioka K, Yokogawa N, Tsuchiya H. The impact of complete surgical resection of spinal metastases on the survival of patients with thyroid cancer. Cancer Med 5: 2343-2349, 2016
  6.  
  7. Kato S, Gasbarrini A, Ghermandi R, Gambarotti, M, Babdiera S. Spinal chordomas dedifferentiated to osteosarcoma: a report of two cases and a literature review. Eur Spine J 25(Suppl 1):251-256, 2016
  8.  
  9. Shinmura K, Murakami H, Tsuchiya H. Second-Generation Total En Bloc Spondylectony (Second-generation TES). In: Landriel FA and Vecchi E. editors. Frontiers in Neurosurgery, Volume 2--[Video Atlas of Spine Surgical Techniques]. Bentham Science Publishers; 2016. p210-224
  10.  
  11. Ishii T, Murakami H, Demura S, Kato S, Yoshioka K, Fujii M, Igarashi T, Tsuchiya H. Invasiveness Reduction of Recent Total En Bloc Spondylectomy: Assessment of the Learning Curve. Asian Spine J 10: 522-527, 2016
  12.  
  13. Sugita S, Murakami H, Kato S, Tanaka S, Tsuchiya H. Disappearance of lung adenocarcinoma after total en bloc spondylectomy using frozen tumor-bearing vertebra for reconstruction. Eur Spine J 25 Suppl 1: 53-57, 2016
  14.  
  15. Kitagawa R, Murakami H, Kato S, Nakada M, Demura S, Tsuchiya H. En bloc resection and reconstruction using a frozen tumor-bearing bone for metastases of the spine and cranium from retroperitoneal paraganglioma. World Neurosurg 90: 698. e1-5, 2016
  16.  
2015年
  1. Murakami H, Kawahara N, Tomita K. Primary and Metastatic Tumors of the Spine: Total En Bloc Spondylectomy. In: S.W. Wiesel. editor. Operative Techniques in Orthopaedic Surgery. 2nd edition. Lippincott Williams & Wilkins; 2015. pp2273-2283.
     
    Demura S, Murakami H, Shirai T, Kato S, Yoshioka K, Ota T, Ishii T, Igarashi T, Tsuchiya H. Surgical treatment for pyogenic vertebral osteomyelitis using iodine-supported spinal instruments: initial case series of 14 patients. Eur J Clin Microbiol Infect Dis 34: 261-266, 2015
     
    Demura S, Murakami H, Hayashi H, Kato S, Yoshioka K, Yokogawa N, Ishii T, Igarashi T, Fang X, Tsuchiya H. Influence of Rod Contouring on Rod Strength and Stiffness in Spine Surgery. Orthopedics 38: e520-523, 2015
     
    Kato S, Murakami H, Demura S, Yoshioka K, Hayashi H, Yokogawa N, Fang X, Tsuchiya H. Gradual spinal cord decompression through migration of floated plaques after anterior decompression via a posterolateral approach for OPLL in the thoracic spine. J Neurosurg Spine 23: 479-483, 2015
     
    Yoshioka K, Murakami H, Demura S, Kato S, Tsuchiya H. Prevalence and Risk factors for Development of Venous Thromboembolism after Degenerative Spinal Surgery. Spine (Phila Pa 1976) 40: E301-306, 2015
     
    Yoshioka K, Murakami H, Demura S, Kato S, Tsuchiya H. Mini-open transthoracic approach for resection of a calcified herniated thoracic disc and repair of the dural surface with fibrin glue: a case report. J Orthop Surg (Hong Kong) 23: 243-246, 2015
     
    Yoshioka K, Murakami H, Demura S, Kato S, Kawahara N, Tomita K, Tsuchiya H. Spinal Metastasis from Subcutaneous Sacrococcygeal Ependymoma: A Case Report with Long-Term Follow-Up. Surg J DOI: 10.1055/s-0035-1567878, 2015
     
    Yoshioka K, Matsuda E, Murakami H, Tsuchiya H. Microendoscopic Excision of Osteoid Osteoma in the Pedicle of the Third Lumbar Vertebra. Asian Spine J 9: 958-961, 2015
     
    Sasagawa T, Murakami H, Maruhashi Y, Segawa T, Yamamoto D, Shimizu S, Morita Y, Nakamura T. Iatrogenic Lumbar Vertebral Fracture during Osteosynthesis for a Trochanteric Fracture of the Femur in Diffuse Idiopathic Skeletal Hyperostosis. Asian Spine J 9: 803-806, 2015
     
    Okamoto Y, Murakami H, Demura S, Kato S, Yoshioka K, Hayashi H, Sakamoto J, Kawahara N, Tsuchiya H. The effect of kyphotic deformity due to vertebral fracture - a finite element analysis of a 10 and 20 degree wedge-shaped vertebral fracture model -. Spine J 15: 713-720, 2015
     
    Hayashi H, Murakami H, Demura S, Kato S, Kawahara N, Tsuchiya H. Outcome of posterior lumbar interbody fusion for L4-L5 degenerative spondylolisthesis. Indian J Orthop 49: 284-288, 2015
     
    Hayashi H, Murakami H, Demura S, Kato S, Yoshioka K, Shinmura K, Yokogawa N, Ishii T, Fang X, Shirai T, Tsuchiya H. Surgical site infection after total en bloc spondylectomy: risk factors and the preventive new technology. Spine J 15: 132-137, 2015
     
    Hayashi H, Toribatake Y, Murakami H, Yoneyama T, Watanabe T, Tsuchiya H. Gait Analysis Using a Support Vector Machine for Lumbar Spinal Stenosis. Orthopedics 38: e959-964, 2015
     
    Shinmura K, Murakami H, Demura S, Kato S, Yoshioka K, Hayashi H, Yokogawa N, Igarashi T, Fujii M, Yonezawa N, Tsuchiya H. Implantation of Liquid Nitrogen Frozen Tumor Tissue after Posterior Decompression and Stabilization for Metastatic Spinal Tumors. Asian Spine J 9: 869-875, 2015
     
    Yokogawa N, Toribatake Y, Murakami H, Hayashi H, Yoneyama T, Watanabe T, Tsuchiya H. Differences in gait characteristics of patients with lumbar spinal canal stenosis (L4 radiculopathy) and those with osteoarthritis of the hip. PLoS One 10: e0124745, 2015
     
    Yokogawa N, Murakami H, Demura S, Kato S, Yoshioka K, Hayashi H, Ishii T, Igarashi T, Fang X, Tsuchiya H. Postoperative Cerebrospinal Fluid Leakage Associated With Total En Bloc Spondylectomy. Orthopedics 38: e561-e566, 2015
     
    Yokogawa N, Murakami H, Demura S, Kato S, Yoshioka K, Yamamoto M, Iseki S, Tsuchiya H. Effects of Radiation on Spinal Dura Mater and Surrounding Tissue in Mice. PLoS One 10: e0133806, 2015
     
    Sugita S, Murakami H, Demura S, Kato S, Yoshioka K, Yokogawa N, Tanaka S, Tsuchiya H. Repeated total en bloc spondylectomy for spinal metastases at different sites in one patient. Eur Spine J 23: 2196-2200, 2015
     
    Kimura H, Fujibayashi S, Shimizu T, Otsuki B, Murakami H, Kaido T, Uemoto S, Matsuda S. Successful Total En Bloc Spondylectomy of T7 Vertebra for Hepatocellular Carcinoma Metastasis after Living Donor Liver Transplantation. Spine (Phila Pa 1976) 40: E944-947, 2015

2014年
  1. Murakami H, Kato S, Ueda Y, Fujimaki Y, Tsuchiya H. Reconstruction using a frozen tumor-bearing vertebra in total en bloc spondylectomy can enhance antitumor immunity. Eur Spine J 23 Suppl 2: 222-227, 2014
     
    Murakami H, Demura S, Kato S, Yoshioka K, Hayashi H, Inoue K, Ota T, Shinmura K, Yokogawa N, Fang X, Tsuchiya H. Systemic antitumor immune response following reconstruction using frozen autografts for total en bloc spondylectomy. Spine J 14: 1567-1571, 2014
     
    Murakami H, Tomita K, Kawahara N, Demura S. En Bloc Spondylectomy: Single-Stage Thoracic Spine. In: Ames CP, et al. editors. Spine and Spinal Cord Tumors: Advanced Management and Operative Techniques. QMP/ CRC Press; 2014. p719-734.
     
    Demura S, Tomita K, Kawahara N, Murakami H. Scoring System for Metastatic Tumors: Palliative or Aggressive Resection and Reconstruction. In: Ames CP, et al. editors. Spine and Spinal Cord Tumors: Advanced Management and Operative Techniques. QMP/ CRC Press; 2014. p53-61.
     
    Fujimaki Y, Murakami H, Tomita K, Kawahara N. T-Saw Laminoplasty. In: Ames CP, et al. editors. Spine and Spinal Cord Tumors: Advanced Management and Operative Techniques. QMP/ CRC Press; 2014. p487-495.
     
    Kato S, Murakami H, Demura S, Yoshioka K, Kawahara N, Tomita K, Tsuchiya H. More Than 10-Year Follow-Up After Total En Bloc Spondylectomy for Spinal Tumors. Ann Surg Oncol 21: 1330-1336, 2014
     
    Kato S, Murakami H, Demura S, Yoshioka K, Kawahara N, Tomita K, Tsuchiya H. Patient-reported outcome and quality of life after total en bloc spondylectomy for a primary spinal tumour. Bone Joint J 96-B: 1693-1698, 2014
     
    Kato S, Murakami H, Demura S, Yoshioka K, Hayashi H, Yokogawa N, Fang X, Tsuchiya H. Vertebral Osteomyelitis Caused by Mycobacterium abscessus Surgically Treated Using Antibacterial Iodine-Supported Instrumentation. Case Rep Orthop. 2014; 197061. Epub 2014 Dec 2.
     
    Sasagawa T, Hashimoto F, Nakamura T, Maruhasi Y, Matsumoto N, Segawa T, Yamamoto D, Goshima K, Murakami H, Tsuchiya H. A Pediatric Case of Single-level Idiopathic Cervical Intervertebral Disk Calcification With Symptom Relapse 1 Year After Initial Onset. J Pediatr Orthop 34: 282-286, 2014
     
    Yokogawa N, Murakami H, Demura S, Kato S, Yoshioka K, Hayashi H, Ishii T, Igarashi T, Fang X, Tsuchiya H. Perioperative Complications of Total En Bloc Spondylectomy: Adverse Effects of Preoperative Irradiation. PLoS One 9: e98797, 2014
     
    Yokogawa N, Murakami H, Demura S, Kato S, Yoshioka K, Hayashi H, Ishii T, Fujii M, Igarashi T, Tsuchiya H. Motor Function of the Upper-Extremity after Transection of the Second Thoracic Nerve Root during Total En Bloc Spondylectomy. PLoS One 9: e109838, 2014
     
    Fang X, Murakami H, Demura S, Hayashi K, Matsubara H, Kato S, Yoshioka K, Inoue K, Ota T, Shinmura K, Tsuchiya H. A Novel Method to Apply Osteogenic Potential of Adipose Derived Stem Cells in Orthopaedic Surgery. PLoS One 9: e88874, 2014
     
    Tawara D, Noro K, Tsujikami T, Okamoto Y, Murakami H. Nonlinear mechanical analysis of posterior spinal instrumentation for osteoporotic vertebra: effects of mechanical properties of the rod on the failure risks around the screw. Journal of Biomechanical Science and Engineering 9: 13-00163, 2014
     
    Ito Z, Higashino K, Kato S, Kim SS, Wong E, Yoshioka K, Hutton WC. Pedicle screws can be 4 times stronger than lateral mass screws for insertion in the mid-cervical spine: a biomechanical study on strength of fixation. J Spinal Disord Tech 27(2): 80-5, 2014
     
    Sangadala S, Yoshioka K, Enyo Y, Liu Y, Titus L, Boden SD. Characterization of a unique motif in LIM mineralization protein-1 that interacts with jun activation-domain-binding protein 1. Mol Cell Biochem 385: 145-157, 2014
 
2013年
  1. Tomita K, Kawahara N, Murakami H. Primary and Metastatic Tumors of the Spine: Total En Bloc Spondylectomy. In: J.M. Rhee, S.D. Boden, J.M. Flynn, S.W. Wiesel. editors. Operative Techniques in Spine Surgery. Lippincott Williams & Wilkins; 2013. P212-220.
  2.  
  3. Murakami H, Demura S, Kato S, Nishida H, Yoshioka K, Hayashi H, Inoue K, Ota T, Shinmura K, Yokogawa N, Fang X, Tsuchiya H: Increase of IL-12 following Reconstruction for Total En Bloc Spondylectomy Using Frozen Autografts Treated with Liquid Nitrogen. PLoS One. 8: e64818, 2013.
  4.  
  5. Murakami H, Kato S, Demura S, Yoshioka K, Hayashi H, Inoue K, Ota T, Shinmura K, Yokogawa N, Fang X, Tsuchiya H: Novel Reconstruction Technique Using a Frozen Tumor-bearing Vertebra From a Total En Bloc Sponydylectomy for Spinal Tumors. Orthopedics. 36: 605-7, 2013.
  6.  
  7. Demura S, Murakami H, Kawahara N, Kato S, Yoshioka K, Tsuchiya H: Laminoplasty and pedicle screw fixation for cervical myelopathy associated with athetoid cerebral palsy: minimum 5-year follow-up. Spine 38: 1764-9, 2013.
  8.  
  9. Demura S, Takahashi K, Murakami H, Fujimaki Y, Kato S, Tsuchiya H: The influence of steroid administration on systemic response in laminoplasty for cervical myelopathy. Arch Orthop Trauma Surg. 133: 1041-5, 2013.
  10.  
  11. Demura S, Yaszay B, Carreau JH, Upsani VV, Bastrom TP, Bartley CE, Newton PO: Maintenance of thoracic kyphosis in the 3D correction of thoracic adolescent idiopathic scoliosis using direct vertebral derotation. Spine deformity 1: 46-50. 2013.
  12.  
  13. Demura S, Yaszay B, Bastrom TP, Carreau J, Newton PO, Harms Study Group: Is decompensation preoperatively a risk in Lenke 1C curves? Spine 38: e649-55, 2013.
  14.  
  15. Demura S, Bastrom TP, Schlechter J, Yaszay B, Newton PO, Harms Study Group: Should Postoperative Pulmonary Function be a Criterion that Affects Upper Instrumented Vertebra Selection in Adolescent Idiopathic Scoliosis Surgery? Spine 38: 1920-6, 2013.
  16.  
  17. Kato S, Murakami H, Demura S, Yoshioka K, Ota T, Shinmura K, Yokogawa N, Kawahara N, Tomita K, Tsuchiya H: Patient and family satisfaction with en bloc total resection as a treatment for solitary spinal metastasis. Orthopedics 36: e1424-30, 2013.
  18.  
  19. Kato S, Murakami H, Takeuchi A, Demura S, Yoshioka K, Kawahara N, Tomita K, Tsuchiya H: Fifteen-year survivor of renal cell carcinoma after metastasectomies for multiple bone metastases. Orthopedics 36: e1454-7, 2013.
  20.  
  21. Yoshioka K, Murakami H, Demura S, Kato S, Kawahara N, Tomita K, Tsuchiya H: Clinical outcome of spinal reconstruction after total en bloc spondylectomy at 3 or more levels. Spine 38:E1511-6, 2013.
  22.  
  23. Yoshioka K, Murakami H, Demura S, Kato S, Hayashi H, Inoue K, Ota T, Shinmura K, Yokogawa N, Fang X, Tsuchiya H: Comparative study of the prevalence of venous thromboembolism after elective spinal surgery. Orthopedics. 36: e223-8. 2013.
  24.  
  25. Okayama T, Murakami H, Demura S, Kawahara N, Tomita K, Tsuchiya H. A Biomechanical Study on Laminectomy and Dekyphosis for Thoracic Ossification of the Posterior Longitudinal Ligament. Advances in Mechanical Engineering Vol. 2013, Article ID 928071, 2013
  26.  
  27. Sasagawa T, Hashimoto F, Nakamura T, Maruhasi Y, Matsumoto N, Segawa T, Yamamoto D, Goshima K, Murakami H, Tsuchiya H. A Pediatric Case of Single-level Idiopathic Cervical Intervertebral Disk Calcification With Symptom Relapse 1 Year After Initial Onset. J Pediatr Orthop 34: 282-286, 2013
  28.  
  29. Karasugi T, Nakajima M, Ikari K; Genetic Study Group of Investigation Committee on Ossification of the Spinal Ligaments, Tsuji T, Matsumoto M, Chiba K, Uchida K, Kawaguchi Y, Mizuta H, Ogata N, Iwasaki M, Maeda S, Numasawa T, Abumi K, Kato T, Ozawa H, Taguchi T, Kaito T, Neo M, Yamazaki M, Tadokoro N, Yoshida M, Nakahara S, Endo K, Imagama S, Demura S, Sato K, Seichi A, Ichimura S, Watanabe M, Watanabe K, Nakamura Y, Mori K, Baba H, Toyama Y, Ikegawa S.J: A genome-wide sib-pair linkage analysis of ossification of the posterior longitudinal ligament of the spine. Bone Miner Metab. 31(2): 136-43, 2013.
  30.  
  31. Wong E, Sangadala S, Boden SD, Yoshioka K, Hutton WC, Oliver C, Titus L. A novel low-molecular-weight compound enhances ectopic bone formation and fracture repair. J Bone Joint Surg Am 6;95(5):454-61,2013
 
2012年
  1. Demura S, Kawahara N, Murakami H, Akamaru T, Kato S, Oda M, Tomita K, Tsuchiya H: Giant cell tumor expanded into the thoracic cavity with spinal involvement. Orthopedics. 35: e453-6, 2012. 
  2.  
  3. Ueda Y, Kawahara N, Murakami H, Demura S, Tsuchiya H: Thoracic disk herniation with paraparesis treated with transthoracic microdiskectomy in a 14-year-old girl. Orthopedics. 35: e774-777, 2012.
  4.  
  5. Ueda Y, Murakami H, Demura S, Kawahara N, Tomita K, Tsuchiya H: Eosinophilic granuloma of the lumbar spine in an adult. Orthopedics. 35:e1818-1821, 2012.
  6.  
  7. Kato S, Murakami H, Demura S, Yoshioka K, Okamoto Y, Hayashi H, Tsuchiya H: Epidural inflammatory pseudotumor in the thoracic spine in a patient with polymyalgia rheumatica. Spine J. 12: e1-4, 2012.
  8.  
  9. Kato S, Murakami H, Higashino K, Okada M, Ito Z, Demura S, Kawahara N, Tomita K, Tsuchiya H, Hutton WC.: The effect of spinal shortening after total en bloc spondylectomy: a biomechanical study in the thoracic spine. J Spinal Disord Tech. 25: E183-90, 2012.
  10.  
  11. Kato S, Murakami H, Minami T, Demura S, Yoshioka K, Matsui O, Tsuchiya H: Preoperative embolization significantly decreases intraoperative blood loss during palliative surgery for spinal metastasis. Orthopedics. 35: e1389-95, 2012.
  12.  
  13. Kato S, Murakami H, Demura S, Yoshioka K, Hayashi H, Tsuchiya H: A novel surgical technique for ossification of posterior longitudinal ligament in the thoracic spine. J Neurosurg Spine. 17: 525-9, 2012.
  14.  
  15. Yoshioka K, Kawahara N, Murakami H, Demura S, Matsuda M, Tomita K: A glass foreign body migrating into the lumbar spinal canal: a case report. J Orthop Surg (Hong Kong). 2:257-9, 2012.
  16.  
  17. Sasagawa T, Kunogi J, Masuyama S, Ogihara S, Takeuchi Y, Takeshita Y, Fukushima M, Kamiya N, Murakami H, Tsuchiya H: The clinical utility of a one-shot energy subtraction method for thoracic spine radiography. J Orthop Sci 17: 346-351, 2012.
 
2011年
  1. Kawahara N, Tomita K, Murakami H, Demura S, Yoshioka K, Kato S. Total En Bloc Spondylectomy of the Lower Lumbar Spine: A Surgical Techniques of Combined Posterior-Anterior Approach. Spine (Phila Pa 1976) 36: 74-82, 2011.
  2.  
  3. Demura S, Kawahara N, Murakami H, Abdel-Wanis ME, Kato S, Yoshioka K, Tomita K, Tsuchiya H. Total en bloc spondylectomy for spinal metastases in thyroid carcinoma. J Neurosurg Spine 14: 172-176, 2011.
  4.  
  5. Kato S, Sangadala S, Tomita K, Titus L, Boden S. A LMP-1 Mimetic Compound that Potentiates Bone Morphogenetic Protein-2 Activity in Inducing Transdifferentiation of C2C12 Myoblasts into the Osteoblastic Phenotype. Mol Cell Biochem 349: 97-106, 2011.
  6.  
  7. Kato S, Kawahara N, Murakami H, Demura S, Yoshioka K, Okamoto Y, Tomita K, Tsuchiya H. Extensive thoracolumbar spinal tuberculosis treated with two-stage surgery using a minimally invasive posterior instrumentation. Eur J Orthop Surg Traumatol 21: 407-409, 2011.
  8.  
  9. Sasagawa T, Kunogi J, Masuyama S, Ogihara S, Takeuchi Y, Takeshita Y, Kamiya N, Murakami H, Tsuchiya H. New Computed Radiography Processing Condition for Whole-spine Radiography. Orthopedics 34: e906-910, 2011.
  10.  
  11. Sasagawa T, Kawahara N, Murakami H, Demura S, Yoshioka K, Yamaguchi T, Tsuchiya H, Tomita K. The route of metastatic vertebral tumors extending to the adjacent vertebral body: a histological study. J Orthop Sci 16: 203-211, 2011.
  12.  
  13. Furukawa Y, Hamaguchi A, Nozaki I, Iizuka T, Sasagawa T, Shima Y, Demura S, Murakami H, Kawahara N, Okuyama T, Iwasa K, Yamada M. Cervical pachymeningeal hypertrophy as the initial and cardinal manifestation of mucopolysaccharidosis type I in monozygotic twins with a novel mutation in the alpha-l-iduronidase gene. J Neurol Sci 302: 121-125, 2011.
  14.  
  15. Hayashi Y, Nakada M, Mohri M, Murakami H, Kawahara N, Hamada JI. Ganglioglioma of the Thoracolumbar Spinal Cord in a Patient with Neurofibromatosis Type 1: A Case Report and Literature Review. Pediatr Neurosurg 47: 210-213, 2011.
  16.  
  17. Sakai K, Ono K, Okamoto Y, Murakami H, Yamada M. Cervical flexion myelopathy in a patient showing apparent long tract signs: A severe form of Hirayama disease. Joint Bone Spine 78: 316-318, 2011.
  18.  
  19. Tawara D, Sakamoto J, Murakami H, Kawahara N, Tomita K. Patient-specific finite element analyses detect significant mechanical therapeutic effects on osteoporotic vertebrae during a three-year treatment. J of Biomechanical Science and Engineering 6: 248-261, 2011.
  20.  
  21. Fourney DR, Frangou EM, Ryken TC, Dipaola CP, Shaffrey CI, Berven SH, Bilsky MH, Harrop JS, Fehlings MG, Boriani S, Chou D, Schmidt MH, Polly DW, Biagini R, Burch S, Dekutoski MB, Ganju A, Gerszten PC, Gokaslan ZL, Groff MW, Liebsch NJ, Mendel E, Okuno SH, Patel S, Rhines LD, Rose PS, Sciubba DM, Sundaresan N, Tomita K, Varga PP, Vialle LR, Vrionis FD, Yamada Y, Fisher CG. Spinal instabiliry neoplastic score: an analysis of reliability and validity from the spine oncology study group. J Clin Oncol 29: 3072-3077, 2011.
 
2010年
  1. Tomita K, Kawahara N, Murakami H. Primary and Metastatic Tumors of the Spine: Total En Bloc Spondylectomy. In: S.W. Wiesel. editor. Operative Techniques in Orthopaedic Surgery. Lippincott Williams & Wilkins; 2010. P1846-1854.
  2.  
  3. Kawahara N, Tomita K, Murakami H, Demura S, Yoshioka K, Miyazaki T. Total excision of a recurrent chondrosarcoma of the thoracic spine: a case report of a seven-year-old boy with fifteen years follow-up. Spine 35: E481-487, 2010.
  4.  
  5. Murakami H, Kawahara N, Tomita K, Demura S, Kato S, Yoshioka K. Does interruption of the artery of Adamkiewicz during total en bloc spondylectomy affect neurologic function? Spine 35: E1187-E1192, 2010.
  6.  
  7. Murakami H, Kawahara N, Demura S, Kato S, Yoshioka K, Tomita K. Total en bloc spondylectomy for lung cancer metastasis to the spine. J Neurosurg Spine 13: 414-417, 2010.
  8.  
  9. Murakami H, Kawahara N, Demura S, Kato S, Yoshioka K, Tomita K. Neurological function after total en bloc spondylectomy for thoracic spinal tumors. J Neurosurg Spine 12: 253-256, 2010.
  10.  
  11. Murakami H, Kawahara N, Tomita K. Editorial response. J Neurosurg Spine 13: 412-413, 2010.
  12.  
  13. Murakami H, Kawahara N, Demura S, Kato S, Yoshioka K, Sasagawa T, Tomita K. Perioperative Complications and Prognosis for Elderly Patients With Spinal Metastases Treated by Surgical Strategy. ORTHOPEDICS 33: 165, 2010.
  14.  
  15. Kato S, Kawahara N, Murakami H, Demura S, Yoshioka K, Okayama T, Fujita T, Tomita K. Surgical management of aggressive vertebral hemangiomas causing spinal cord compression: long-term clinical follow-up of five cases. J Orthop Sci 15: 350-356, 2010.
  16.  
  17. Kato S, Kawahara N, Murakami H, Demura S, Shirai T, Tsuchiya H, Tomita K. Multi-Level Total En Bloc Spondylectomy for Solitary Lumbar Metastasis of Myxoid Liposarcoma. Orthopedics 33: 446, 2010.
  18.  
  19. Yoshioka K, Kitajima I, Kabata T, Tani M, Kawahara N, Murakami H, Demura S, Tsubokawa T, Tomita K. Venous thromboembolism after spine surgery: changes of the fibrin monomer complex and D-dimer level during the perioperative period. J Neurosurg Spine 13: 594-599, 2010.
  20.  
  21. Tawara D, Sakamoto J, Murakami H, Kawahara N, Oda J, Tomita K. Mechanical evaluation by patient-specific finite element analyses demonstrates therapeutic effects for osteoporotic vertebrae. J Mech Behav Biomed Mater 3: 31-40, 2010.
  22.  
  23. Tawara D, Sakamoto J, Murakami H, Kawahara N, Oda J, Tomita K. Mechanical Therapeutic Effects in Osteoporotic L1-Vertebrae Evaluated by Nonlinear Patient-specific Finite Element Analysis. J of Biomechanical Science and Engineering 5: 499-514, 2010.