金沢大学附属病院 整形外科

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脊椎外科班

     
     
     
     
臨床研究
 
 大学の脊椎グループは平成27年7月現在、私(村上)、出村諭講師、加藤仁志助教、吉岡克人特任助教の4人のスタッフと林寛之先生(金沢医療センター)、井上啓先生(河北中央病院)、太田敬先生(やわたメディカルセンター)、新村和也先生(金沢市立病院)、横川文彬先生(藤井脳神経外科病院)、藤井衛之先生、五十嵐峻先生、米澤則隆先生、高橋直樹先生の9人の大学院生で構成されています。脊椎分野は範囲がとても広く、疾患も多岐にわたりますが、金沢大学では脊椎のどの分野も全国トップレベルを保ちたいとの考えから、4人のスタッフがそれぞれに専門性を出して診療しています。私は富田勝郎先生、川原範夫先生の流れを引き継いで脊椎腫瘍を中心に、出村先生は側弯症などの脊柱変形に、加藤先生は胸椎OPLLなど脊柱靭帯骨化症と腰痛症に、吉岡先生は内視鏡手術に、特に力を入れてやっています。1つの大学(病院)でここまで多岐にわたって(高侵襲手術から低侵襲手術・保存療法まで、変性疾患から癌まで)ハイレベルの診療をやっているところはそうそうないと自負しています。
 脊椎腫瘍に関しては、私が脊椎グループのチーフになってから丸5年が経ちましたが、腫瘍脊椎骨全摘術(TES)の症例数は100例を超えました(現在118例)。今ではTESはついに平均出血量400mlの手術となりました。お陰様で日本全国から次々とTESの症例が紹介されてきます。特に最近では泌尿器科からの講演依頼が多く、日本全国の泌尿器科の先生方から直接相談されるようになってきています。出村先生は脊柱変形の分野におけるオーソリティーの1人にまで成長し、全国的な多施設研究にも参加して活躍しています。夏休み、冬休み、春休みには毎週、側弯症の手術が予約されています。加藤先生は今年、日本脊椎脊髄病学会の最高峰の賞である大正富山アワードを獲得しました。さらに彼は、ロコモ患者のための体幹筋力の測定とトレーニングを両立した運動器具を開発して特許を取得しました。すでに慢性腰痛患者に対するこの運動器具を使用した研究がスタートしています。彼の勢いは留まるところを知りません。吉岡先生は今や内視鏡手術のスペシャリストです。腰椎だけでなく頸椎や胸椎、そしていろいろな疾患に内視鏡を取り入れ、北陸における内視鏡手術の普及に尽力しています。臨床ではこれらの他に、土屋教授の開発されたヨードコーティングインプラントを使用して難治性の脊椎感染症の手術を果敢に行っています。また、富山県立中央病院の笹川武史先生には、大学に時々来て頂き出村先生と共同で全脊柱のレントゲン評価を行ってもらっています
     
 
基礎研究
 
 基礎研究に関しては、林先生は、厚生連高岡病院の鳥畠康充副院長と金沢大学運動生体管理学の藤原勝夫教授のご協力のもと脊柱管狭窄症患者の歩行解析に取り組み、学位論文を仕上げ、ついに英文誌にacceptされました。井上先生は、椎体再建におけるcage内骨癒合を脂肪由来幹細胞で促進できることを証明し、現在、論文作成中です。太田先生は、ヨードコーティング脊椎screwの骨親和性を確かめる実験をしています。教室の仕事の大きな柱の1つであるヨードコーティングインプラントの有用性を証明する重要な実験です。新村先生は、新しいTESにおける液体窒素処理骨のcage内骨癒合を調べ、液体窒素処理骨でもしっかりと骨癒合が得られることを証明しました。現在、論文作成中です。横川先生は、放射線照射が髄膜に与える影響を明らかにし、その結果を英文誌に投稿しました。彼はすでに米国のRochester大学に留学が決まっており、さらなる活躍が期待されます。井上先生、太田先生、新村先生、横川先生の研究はいずれも科研費を獲得しています。そして、現在大学にいる藤井先生は、mobile stabilizationが脊椎固定術に与える影響を力学解析しています。これは、龍谷大学理工学部の田原大輔講師のご協力のもと行っています。また、五十嵐先生は、放射線照射が脊椎の骨強度に与える影響を特に骨質に着目して調べています。そして米澤先生は、新しいTESにおける液体窒素処理骨移植が全身のがん免疫に与える影響を調べています。平成27年4月から新しく脊椎グループに加わった高橋先生は、加藤先生の開発した運動器具を使って慢性腰痛症に対する体幹筋力強化を目的とした運動療法の前向き研究を開始しています。そして本年度はなんと!!出村先生、加藤先生の2人がまたまた科研費を獲得しました。出村先生は藤井先生の研究を基に基盤Cで『不安定性を有する骨粗鬆性脊椎の力学解析-最適な強度を有する固定材料の模索-』、加藤先生は五十嵐先生の研究を基に若手Bで『放射線照射が脊椎の骨強度に与える影響-特に骨質に着目して-』です。これで脊椎グループ大学院生のほぼ全員の研究課題が科研費を獲得していることとなり、昨年に引き続きスタッフ4人全員が科研費を持っていることになります。これは過去に例をみない快挙と言わざるを得ません。
 このような臨床および基礎研究から、平成26年は英文論文を9編発表しました(出村先生、加藤先生2本、吉岡先生、林先生、横川先生2本、方向先生、岡本義之先生です)。さらに平成27年4月の第44回日本脊椎脊髄病学会では、大学の脊椎グループで22演題も採用されました。昨年の採用は16演題ですから、またさらに大きく飛躍したことになります。22演題中口演が17演題もあり、これも昨年の14演題を上回りました。中でも横川先生は一人で4つの口演を行いました。凄いです!!お疲れ様でした。この学会では口演の採用率が40.7%でしたから、今年もおそらく口演数は日本全国の施設の中でナンバー5には間違いなく入っています。ここまで金沢大学脊椎グループが活躍できるのもメンバーひとりひとりの頑張りの賜物です。さらに継続努力し、英文論文も書いていきたいと思っています(平成27年は現時点ですでにpublish 7本、accept 7本、revise 1本、under review 5本とみんな頑張っています)。
 最後に、脊椎グループでは毎週木曜日の夜8時からオープンカンファランスを行っております。オープンですから脊椎専門外の先生や研修医の先生の参加も大歓迎ですし、途中参加や途中退出も全く構いません(いつも夜10時過ぎくらいまで続きますので)。参加をお待ちしています。
     
 
業績
 
英語論文(2010~2016)
2016年
  1. Demura S, Murakami H, Kato S, Yoshioka K, Fujii M, Igarashi T, Yonezawa N, Takahashi N, Tsuchiya H. Posterior curve correction using convex posterior hemi-interbody arthrodesis in skeletally immature patients with scoliosis. Spine J. 2016 May 30. [Epub ahead of print]
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  3. Kato S, Murakami H, Demura S, Nambu K, Fujimaki Y, Yoshioka K, Kawahara N, Tomita K, Tsuchiya H. Spinal metastasectomy of renal cell carcinoma: A 16-year single center experience with a minimum 3-year follow-up. J Surg Oncol 113: 587-592, 2016
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  5. Shinmura K, Murakami H, Tsuchiya H. Second-Generation Total En Bloc Spondylectony (Second-Generation TES) in: Landriel FA and Vecchi E. editors. Frontiers in Neurosurgery, Volume 2--[Video Atlas of Spine Surgical Techniques]. Bentham Science Publishers; 2016. p210-224
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  7. Sugita S, Murakami H, Kato S, Tanaka S, Tsuchiya H. Disappearance of lung adenocarcinoma after total en bloc spondylectomy using frozen tumor-bearing vertebra for reconstruction. Eur Spine J 25 Suppl 1: 53-57, 2016
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2015年
  1. Murakami H, Fujimaki Y, Yoshioka K, Kawahara N, Tsuchiya H. Reconstruction using frozen tumour-bearing vertebra en bloc after total spondylectomy. J Orthop Sci. 2015 Aug 5. [Epub ahead of print]
     
    Murakami H, Kawahara N, Tomita K. Primary and Metastatic Tumors of the Spine: Total En Bloc Spondylectomy. In: S.W. Wiesel. editor. Operative Techniques in Orthopaedic Surgery. 2nd edition. Lippincott Williams & Wilkins; 2015. pp2273-2283.
     
    Demura S, Murakami H, Shirai T, Kato S, Yoshioka K, Ota T, Ishii T, Igarashi T, Tsuchiya H. Surgical treatment for pyogenic vertebral osteomyelitis using iodine-supported spinal instruments: initial case series of 14 patients. Eur J Clin Microbiol Infect Dis 34: 261-266, 2015
     
    Demura S, Murakami H, Hayashi H, Kato S, Yoshioka K, Yokogawa N, Ishii T, Igarashi T, Fang X, Tsuchiya H. Influence of Rod Contouring on Rod Strength and Stiffness in Spine Surgery. Orthopedics 38: e520-523, 2015
     
    Kato S, Murakami H, Demura S, Yoshioka K, Hayashi H, Yokogawa N, Fang X, Tsuchiya H. Gradual spinal cord decompression through migration of floated plaques after anterior decompression via a posterolateral approach for OPLL in the thoracic spine. J Neurosurg Spine 23: 479-483, 2015
     
    Yoshioka K, Murakami H, Demura S, Kato S, Tsuchiya H. Prevalence and Risk factors for Development of Venous Thromboembolism after Degenerative Spinal Surgery. Spine (Phila Pa 1976) 40: E301-306, 2015
     
    Yoshioka K, Murakami H, Demura S, Kato S, Tsuchiya H. Mini-open transthoracic approach for resection of a calcified herniated thoracic disc and repair of the dural surface with fibrin glue: a case report. J Orthop Surg (Hong Kong) 23: 243-246, 2015
     
    Yoshioka K, Murakami H, Demura S, Kato S, Kawahara N, Tomita K, Tsuchiya H. Spinal Metastasis from Subcutaneous Sacrococcygeal Ependymoma: A Case Report with Long-Term Follow-Up. Surg J DOI: 10.1055/s-0035-1567878, 2015
     
    Yoshioka K, Matsuda E, Murakami H, Tsuchiya H. Microendoscopic Excision of Osteoid Osteoma in the Pedicle of the Third Lumbar Vertebra. Asian Spine J 9: 958-961, 2015
     
    Sasagawa T, Murakami H, Maruhashi Y, Segawa T, Yamamoto D, Shimizu S, Morita Y, Nakamura T. Iatrogenic Lumbar Vertebral Fracture during Osteosynthesis for a Trochanteric Fracture of the Femur in Diffuse Idiopathic Skeletal Hyperostosis. Asian Spine J 9: 803-806, 2015
     
    Okamoto Y, Murakami H, Demura S, Kato S, Yoshioka K, Hayashi H, Sakamoto J, Kawahara N, Tsuchiya H. The effect of kyphotic deformity due to vertebral fracture - a finite element analysis of a 10 and 20 degree wedge-shaped vertebral fracture model -. Spine J 15: 713-720, 2015
     
    Hayashi H, Murakami H, Demura S, Kato S, Kawahara N, Tsuchiya H. Outcome of posterior lumbar interbody fusion for L4-L5 degenerative spondylolisthesis. Indian J Orthop 49: 284-288, 2015
     
    Hayashi H, Murakami H, Demura S, Kato S, Yoshioka K, Shinmura K, Yokogawa N, Ishii T, Fang X, Shirai T, Tsuchiya H. Surgical site infection after total en bloc spondylectomy: risk factors and the preventive new technology. Spine J 15: 132-137, 2015
     
    Hayashi H, Toribatake Y, Murakami H, Yoneyama T, Watanabe T, Tsuchiya H. Gait Analysis Using a Support Vector Machine for Lumbar Spinal Stenosis. Orthopedics 38: e959-964, 2015
     
    Shinmura K, Murakami H, Demura S, Kato S, Yoshioka K, Hayashi H, Yokogawa N, Igarashi T, Fujii M, Yonezawa N, Tsuchiya H. Implantation of Liquid Nitrogen Frozen Tumor Tissue after Posterior Decompression and Stabilization for Metastatic Spinal Tumors. Asian Spine J 9: 869-875, 2015
     
    Yokogawa N, Toribatake Y, Murakami H, Hayashi H, Yoneyama T, Watanabe T, Tsuchiya H. Differences in gait characteristics of patients with lumbar spinal canal stenosis (L4 radiculopathy) and those with osteoarthritis of the hip. PLoS One 10: e0124745, 2015
     
    Yokogawa N, Murakami H, Demura S, Kato S, Yoshioka K, Hayashi H, Ishii T, Igarashi T, Fang X, Tsuchiya H. Postoperative Cerebrospinal Fluid Leakage Associated With Total En Bloc Spondylectomy. Orthopedics 38: e561-e566, 2015
     
    Yokogawa N, Murakami H, Demura S, Kato S, Yoshioka K, Yamamoto M, Iseki S, Tsuchiya H. Effects of Radiation on Spinal Dura Mater and Surrounding Tissue in Mice. PLoS One 10: e0133806, 2015
     
    Kitagawa R, Murakami H, Kato S, Nakada M, Demura S, Tsuchiya H. En bloc resection and reconstruction using a frozen tumor-bearing bone for metastases of the spine and cranium from retroperitoneal paraganglioma. World Neurosurg. 2015 Oct 9. [Epub ahead of print]
     
    Sugita S, Murakami H, Demura S, Kato S, Yoshioka K, Yokogawa N, Tanaka S, Tsuchiya H. Repeated total en bloc spondylectomy for spinal metastases at different sites in one patient. Eur Spine J 23: 2196-2200, 2015
     
    Kimura H, Fujibayashi S, Shimizu T, Otsuki B, Murakami H, Kaido T, Uemoto S, Matsuda S. Successful Total En Bloc Spondylectomy of T7 Vertebra for Hepatocellular Carcinoma Metastasis after Living Donor Liver Transplantation. Spine (Phila Pa 1976) 40: E944-947, 2015

2014年
  1. Murakami H, Kato S, Ueda Y, Fujimaki Y, Tsuchiya H. Reconstruction using a frozen tumor-bearing vertebra in total en bloc spondylectomy can enhance antitumor immunity. Eur Spine J 23 Suppl 2: 222-227, 2014
     
    Murakami H, Demura S, Kato S, Yoshioka K, Hayashi H, Inoue K, Ota T, Shinmura K, Yokogawa N, Fang X, Tsuchiya H. Systemic antitumor immune response following reconstruction using frozen autografts for total en bloc spondylectomy. Spine J 14: 1567-1571, 2014
     
    Murakami H, Tomita K, Kawahara N, Demura S. En Bloc Spondylectomy: Single-Stage Thoracic Spine. In: Ames CP, et al. editors. Spine and Spinal Cord Tumors: Advanced Management and Operative Techniques. QMP/ CRC Press; 2014. p719-734.
     
    Demura S, Tomita K, Kawahara N, Murakami H. Scoring System for Metastatic Tumors: Palliative or Aggressive Resection and Reconstruction. In: Ames CP, et al. editors. Spine and Spinal Cord Tumors: Advanced Management and Operative Techniques. QMP/ CRC Press; 2014. p53-61.
     
    Fujimaki Y, Murakami H, Tomita K, Kawahara N. T-Saw Laminoplasty. In: Ames CP, et al. editors. Spine and Spinal Cord Tumors: Advanced Management and Operative Techniques. QMP/ CRC Press; 2014. p487-495.
     
    Kato S, Murakami H, Demura S, Yoshioka K, Kawahara N, Tomita K, Tsuchiya H. More Than 10-Year Follow-Up After Total En Bloc Spondylectomy for Spinal Tumors. Ann Surg Oncol 21: 1330-1336, 2014
     
    Kato S, Murakami H, Demura S, Yoshioka K, Kawahara N, Tomita K, Tsuchiya H. Patient-reported outcome and quality of life after total en bloc spondylectomy for a primary spinal tumour. Bone Joint J 96-B: 1693-1698, 2014
     
    Kato S, Murakami H, Demura S, Yoshioka K, Hayashi H, Yokogawa N, Fang X, Tsuchiya H. Vertebral Osteomyelitis Caused by Mycobacterium abscessus Surgically Treated Using Antibacterial Iodine-Supported Instrumentation. Case Rep Orthop. 2014; 197061. Epub 2014 Dec 2.
     
    Sasagawa T, Hashimoto F, Nakamura T, Maruhasi Y, Matsumoto N, Segawa T, Yamamoto D, Goshima K, Murakami H, Tsuchiya H. A Pediatric Case of Single-level Idiopathic Cervical Intervertebral Disk Calcification With Symptom Relapse 1 Year After Initial Onset. J Pediatr Orthop 34: 282-286, 2014
     
    Yokogawa N, Murakami H, Demura S, Kato S, Yoshioka K, Hayashi H, Ishii T, Igarashi T, Fang X, Tsuchiya H. Perioperative Complications of Total En Bloc Spondylectomy: Adverse Effects of Preoperative Irradiation. PLoS One 9: e98797, 2014
     
    Yokogawa N, Murakami H, Demura S, Kato S, Yoshioka K, Hayashi H, Ishii T, Fujii M, Igarashi T, Tsuchiya H. Motor Function of the Upper-Extremity after Transection of the Second Thoracic Nerve Root during Total En Bloc Spondylectomy. PLoS One 9: e109838, 2014
     
    Fang X, Murakami H, Demura S, Hayashi K, Matsubara H, Kato S, Yoshioka K, Inoue K, Ota T, Shinmura K, Tsuchiya H. A Novel Method to Apply Osteogenic Potential of Adipose Derived Stem Cells in Orthopaedic Surgery. PLoS One 9: e88874, 2014
     
    Tawara D, Noro K, Tsujikami T, Okamoto Y, Murakami H. Nonlinear mechanical analysis of posterior spinal instrumentation for osteoporotic vertebra: effects of mechanical properties of the rod on the failure risks around the screw. Journal of Biomechanical Science and Engineering 9: 13-00163, 2014
     
    Ito Z, Higashino K, Kato S, Kim SS, Wong E, Yoshioka K, Hutton WC. Pedicle screws can be 4 times stronger than lateral mass screws for insertion in the mid-cervical spine: a biomechanical study on strength of fixation. J Spinal Disord Tech 27(2): 80-5, 2014
     
    Sangadala S, Yoshioka K, Enyo Y, Liu Y, Titus L, Boden SD. Characterization of a unique motif in LIM mineralization protein-1 that interacts with jun activation-domain-binding protein 1. Mol Cell Biochem 385: 145-157, 2014
 
2013年
  1. Tomita K, Kawahara N, Murakami H. Primary and Metastatic Tumors of the Spine: Total En Bloc Spondylectomy. In: J.M. Rhee, S.D. Boden, J.M. Flynn, S.W. Wiesel. editors. Operative Techniques in Spine Surgery. Lippincott Williams & Wilkins; 2013. P212-220.
  2.  
  3. Murakami H, Demura S, Kato S, Nishida H, Yoshioka K, Hayashi H, Inoue K, Ota T, Shinmura K, Yokogawa N, Fang X, Tsuchiya H: Increase of IL-12 following Reconstruction for Total En Bloc Spondylectomy Using Frozen Autografts Treated with Liquid Nitrogen. PLoS One. 8: e64818, 2013.
  4.  
  5. Murakami H, Kato S, Demura S, Yoshioka K, Hayashi H, Inoue K, Ota T, Shinmura K, Yokogawa N, Fang X, Tsuchiya H: Novel Reconstruction Technique Using a Frozen Tumor-bearing Vertebra From a Total En Bloc Sponydylectomy for Spinal Tumors. Orthopedics. 36: 605-7, 2013.
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  7. Demura S, Murakami H, Kawahara N, Kato S, Yoshioka K, Tsuchiya H: Laminoplasty and pedicle screw fixation for cervical myelopathy associated with athetoid cerebral palsy: minimum 5-year follow-up. Spine 38: 1764-9, 2013.
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  9. Demura S, Takahashi K, Murakami H, Fujimaki Y, Kato S, Tsuchiya H: The influence of steroid administration on systemic response in laminoplasty for cervical myelopathy. Arch Orthop Trauma Surg. 133: 1041-5, 2013.
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  11. Demura S, Yaszay B, Carreau JH, Upsani VV, Bastrom TP, Bartley CE, Newton PO: Maintenance of thoracic kyphosis in the 3D correction of thoracic adolescent idiopathic scoliosis using direct vertebral derotation. Spine deformity 1: 46-50. 2013.
  12.  
  13. Demura S, Yaszay B, Bastrom TP, Carreau J, Newton PO, Harms Study Group: Is decompensation preoperatively a risk in Lenke 1C curves? Spine 38: e649-55, 2013.
  14.  
  15. Demura S, Bastrom TP, Schlechter J, Yaszay B, Newton PO, Harms Study Group: Should Postoperative Pulmonary Function be a Criterion that Affects Upper Instrumented Vertebra Selection in Adolescent Idiopathic Scoliosis Surgery? Spine 38: 1920-6, 2013.
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  17. Kato S, Murakami H, Demura S, Yoshioka K, Ota T, Shinmura K, Yokogawa N, Kawahara N, Tomita K, Tsuchiya H: Patient and family satisfaction with en bloc total resection as a treatment for solitary spinal metastasis. Orthopedics 36: e1424-30, 2013.
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  19. Kato S, Murakami H, Takeuchi A, Demura S, Yoshioka K, Kawahara N, Tomita K, Tsuchiya H: Fifteen-year survivor of renal cell carcinoma after metastasectomies for multiple bone metastases. Orthopedics 36: e1454-7, 2013.
  20.  
  21. Yoshioka K, Murakami H, Demura S, Kato S, Kawahara N, Tomita K, Tsuchiya H: Clinical outcome of spinal reconstruction after total en bloc spondylectomy at 3 or more levels. Spine 38:E1511-6, 2013.
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  23. Yoshioka K, Murakami H, Demura S, Kato S, Hayashi H, Inoue K, Ota T, Shinmura K, Yokogawa N, Fang X, Tsuchiya H: Comparative study of the prevalence of venous thromboembolism after elective spinal surgery. Orthopedics. 36: e223-8. 2013.
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  25. Okayama T, Murakami H, Demura S, Kawahara N, Tomita K, Tsuchiya H. A Biomechanical Study on Laminectomy and Dekyphosis for Thoracic Ossification of the Posterior Longitudinal Ligament. Advances in Mechanical Engineering Vol. 2013, Article ID 928071, 2013
  26.  
  27. Sasagawa T, Hashimoto F, Nakamura T, Maruhasi Y, Matsumoto N, Segawa T, Yamamoto D, Goshima K, Murakami H, Tsuchiya H. A Pediatric Case of Single-level Idiopathic Cervical Intervertebral Disk Calcification With Symptom Relapse 1 Year After Initial Onset. J Pediatr Orthop 34: 282-286, 2013
  28.  
  29. Karasugi T, Nakajima M, Ikari K; Genetic Study Group of Investigation Committee on Ossification of the Spinal Ligaments, Tsuji T, Matsumoto M, Chiba K, Uchida K, Kawaguchi Y, Mizuta H, Ogata N, Iwasaki M, Maeda S, Numasawa T, Abumi K, Kato T, Ozawa H, Taguchi T, Kaito T, Neo M, Yamazaki M, Tadokoro N, Yoshida M, Nakahara S, Endo K, Imagama S, Demura S, Sato K, Seichi A, Ichimura S, Watanabe M, Watanabe K, Nakamura Y, Mori K, Baba H, Toyama Y, Ikegawa S.J: A genome-wide sib-pair linkage analysis of ossification of the posterior longitudinal ligament of the spine. Bone Miner Metab. 31(2): 136-43, 2013.
  30.  
  31. Wong E, Sangadala S, Boden SD, Yoshioka K, Hutton WC, Oliver C, Titus L. A novel low-molecular-weight compound enhances ectopic bone formation and fracture repair. J Bone Joint Surg Am 6;95(5):454-61,2013
 
2012年
  1. Demura S, Kawahara N, Murakami H, Akamaru T, Kato S, Oda M, Tomita K, Tsuchiya H: Giant cell tumor expanded into the thoracic cavity with spinal involvement. Orthopedics. 35: e453-6, 2012. 
  2.  
  3. Ueda Y, Kawahara N, Murakami H, Demura S, Tsuchiya H: Thoracic disk herniation with paraparesis treated with transthoracic microdiskectomy in a 14-year-old girl. Orthopedics. 35: e774-777, 2012.
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  5. Ueda Y, Murakami H, Demura S, Kawahara N, Tomita K, Tsuchiya H: Eosinophilic granuloma of the lumbar spine in an adult. Orthopedics. 35:e1818-1821, 2012.
  6.  
  7. Kato S, Murakami H, Demura S, Yoshioka K, Okamoto Y, Hayashi H, Tsuchiya H: Epidural inflammatory pseudotumor in the thoracic spine in a patient with polymyalgia rheumatica. Spine J. 12: e1-4, 2012.
  8.  
  9. Kato S, Murakami H, Higashino K, Okada M, Ito Z, Demura S, Kawahara N, Tomita K, Tsuchiya H, Hutton WC.: The effect of spinal shortening after total en bloc spondylectomy: a biomechanical study in the thoracic spine. J Spinal Disord Tech. 25: E183-90, 2012.
  10.  
  11. Kato S, Murakami H, Minami T, Demura S, Yoshioka K, Matsui O, Tsuchiya H: Preoperative embolization significantly decreases intraoperative blood loss during palliative surgery for spinal metastasis. Orthopedics. 35: e1389-95, 2012.
  12.  
  13. Kato S, Murakami H, Demura S, Yoshioka K, Hayashi H, Tsuchiya H: A novel surgical technique for ossification of posterior longitudinal ligament in the thoracic spine. J Neurosurg Spine. 17: 525-9, 2012.
  14.  
  15. Yoshioka K, Kawahara N, Murakami H, Demura S, Matsuda M, Tomita K: A glass foreign body migrating into the lumbar spinal canal: a case report. J Orthop Surg (Hong Kong). 2:257-9, 2012.
  16.  
  17. Sasagawa T, Kunogi J, Masuyama S, Ogihara S, Takeuchi Y, Takeshita Y, Fukushima M, Kamiya N, Murakami H, Tsuchiya H: The clinical utility of a one-shot energy subtraction method for thoracic spine radiography. J Orthop Sci 17: 346-351, 2012.
 
2011年
  1. Kawahara N, Tomita K, Murakami H, Demura S, Yoshioka K, Kato S. Total En Bloc Spondylectomy of the Lower Lumbar Spine: A Surgical Techniques of Combined Posterior-Anterior Approach. Spine (Phila Pa 1976) 36: 74-82, 2011.
  2.  
  3. Demura S, Kawahara N, Murakami H, Abdel-Wanis ME, Kato S, Yoshioka K, Tomita K, Tsuchiya H. Total en bloc spondylectomy for spinal metastases in thyroid carcinoma. J Neurosurg Spine 14: 172-176, 2011.
  4.  
  5. Kato S, Sangadala S, Tomita K, Titus L, Boden S. A LMP-1 Mimetic Compound that Potentiates Bone Morphogenetic Protein-2 Activity in Inducing Transdifferentiation of C2C12 Myoblasts into the Osteoblastic Phenotype. Mol Cell Biochem 349: 97-106, 2011.
  6.  
  7. Kato S, Kawahara N, Murakami H, Demura S, Yoshioka K, Okamoto Y, Tomita K, Tsuchiya H. Extensive thoracolumbar spinal tuberculosis treated with two-stage surgery using a minimally invasive posterior instrumentation. Eur J Orthop Surg Traumatol 21: 407-409, 2011.
  8.  
  9. Sasagawa T, Kunogi J, Masuyama S, Ogihara S, Takeuchi Y, Takeshita Y, Kamiya N, Murakami H, Tsuchiya H. New Computed Radiography Processing Condition for Whole-spine Radiography. Orthopedics 34: e906-910, 2011.
  10.  
  11. Sasagawa T, Kawahara N, Murakami H, Demura S, Yoshioka K, Yamaguchi T, Tsuchiya H, Tomita K. The route of metastatic vertebral tumors extending to the adjacent vertebral body: a histological study. J Orthop Sci 16: 203-211, 2011.
  12.  
  13. Furukawa Y, Hamaguchi A, Nozaki I, Iizuka T, Sasagawa T, Shima Y, Demura S, Murakami H, Kawahara N, Okuyama T, Iwasa K, Yamada M. Cervical pachymeningeal hypertrophy as the initial and cardinal manifestation of mucopolysaccharidosis type I in monozygotic twins with a novel mutation in the alpha-l-iduronidase gene. J Neurol Sci 302: 121-125, 2011.
  14.  
  15. Hayashi Y, Nakada M, Mohri M, Murakami H, Kawahara N, Hamada JI. Ganglioglioma of the Thoracolumbar Spinal Cord in a Patient with Neurofibromatosis Type 1: A Case Report and Literature Review. Pediatr Neurosurg 47: 210-213, 2011.
  16.  
  17. Sakai K, Ono K, Okamoto Y, Murakami H, Yamada M. Cervical flexion myelopathy in a patient showing apparent long tract signs: A severe form of Hirayama disease. Joint Bone Spine 78: 316-318, 2011.
  18.  
  19. Tawara D, Sakamoto J, Murakami H, Kawahara N, Tomita K. Patient-specific finite element analyses detect significant mechanical therapeutic effects on osteoporotic vertebrae during a three-year treatment. J of Biomechanical Science and Engineering 6: 248-261, 2011.
  20.  
  21. Fourney DR, Frangou EM, Ryken TC, Dipaola CP, Shaffrey CI, Berven SH, Bilsky MH, Harrop JS, Fehlings MG, Boriani S, Chou D, Schmidt MH, Polly DW, Biagini R, Burch S, Dekutoski MB, Ganju A, Gerszten PC, Gokaslan ZL, Groff MW, Liebsch NJ, Mendel E, Okuno SH, Patel S, Rhines LD, Rose PS, Sciubba DM, Sundaresan N, Tomita K, Varga PP, Vialle LR, Vrionis FD, Yamada Y, Fisher CG. Spinal instabiliry neoplastic score: an analysis of reliability and validity from the spine oncology study group. J Clin Oncol 29: 3072-3077, 2011.
 
2010年
  1. Tomita K, Kawahara N, Murakami H. Primary and Metastatic Tumors of the Spine: Total En Bloc Spondylectomy. In: S.W. Wiesel. editor. Operative Techniques in Orthopaedic Surgery. Lippincott Williams & Wilkins; 2010. P1846-1854.
  2.  
  3. Kawahara N, Tomita K, Murakami H, Demura S, Yoshioka K, Miyazaki T. Total excision of a recurrent chondrosarcoma of the thoracic spine: a case report of a seven-year-old boy with fifteen years follow-up. Spine 35: E481-487, 2010.
  4.  
  5. Murakami H, Kawahara N, Tomita K, Demura S, Kato S, Yoshioka K. Does interruption of the artery of Adamkiewicz during total en bloc spondylectomy affect neurologic function? Spine 35: E1187-E1192, 2010.
  6.  
  7. Murakami H, Kawahara N, Demura S, Kato S, Yoshioka K, Tomita K. Total en bloc spondylectomy for lung cancer metastasis to the spine. J Neurosurg Spine 13: 414-417, 2010.
  8.  
  9. Murakami H, Kawahara N, Demura S, Kato S, Yoshioka K, Tomita K. Neurological function after total en bloc spondylectomy for thoracic spinal tumors. J Neurosurg Spine 12: 253-256, 2010.
  10.  
  11. Murakami H, Kawahara N, Tomita K. Editorial response. J Neurosurg Spine 13: 412-413, 2010.
  12.  
  13. Murakami H, Kawahara N, Demura S, Kato S, Yoshioka K, Sasagawa T, Tomita K. Perioperative Complications and Prognosis for Elderly Patients With Spinal Metastases Treated by Surgical Strategy. ORTHOPEDICS 33: 165, 2010.
  14.  
  15. Kato S, Kawahara N, Murakami H, Demura S, Yoshioka K, Okayama T, Fujita T, Tomita K. Surgical management of aggressive vertebral hemangiomas causing spinal cord compression: long-term clinical follow-up of five cases. J Orthop Sci 15: 350-356, 2010.
  16.  
  17. Kato S, Kawahara N, Murakami H, Demura S, Shirai T, Tsuchiya H, Tomita K. Multi-Level Total En Bloc Spondylectomy for Solitary Lumbar Metastasis of Myxoid Liposarcoma. Orthopedics 33: 446, 2010.
  18.  
  19. Yoshioka K, Kitajima I, Kabata T, Tani M, Kawahara N, Murakami H, Demura S, Tsubokawa T, Tomita K. Venous thromboembolism after spine surgery: changes of the fibrin monomer complex and D-dimer level during the perioperative period. J Neurosurg Spine 13: 594-599, 2010.
  20.  
  21. Tawara D, Sakamoto J, Murakami H, Kawahara N, Oda J, Tomita K. Mechanical evaluation by patient-specific finite element analyses demonstrates therapeutic effects for osteoporotic vertebrae. J Mech Behav Biomed Mater 3: 31-40, 2010.
  22.  
  23. Tawara D, Sakamoto J, Murakami H, Kawahara N, Oda J, Tomita K. Mechanical Therapeutic Effects in Osteoporotic L1-Vertebrae Evaluated by Nonlinear Patient-specific Finite Element Analysis. J of Biomechanical Science and Engineering 5: 499-514, 2010.